Levels of oxidative stress, selenium and zinc, and health-related quality of life in healthy males before and after COVID-19 vaccination

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dc.authoridSaruhan, Ercan/0000-0001-6416-1442
dc.contributor.authorOzdemir, Kadirhan
dc.contributor.authorSaruhan, Ercan
dc.contributor.authorBenli, Tuba Kaya
dc.contributor.authorKaya, Gozde
dc.contributor.authorCil, Zafer
dc.contributor.authorYavuz, Melike Yuksel
dc.contributor.authorMeral, Orhan
dc.date.accessioned2025-03-20T09:50:26Z
dc.date.available2025-03-20T09:50:26Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractObjective: The aim of this study was to determine the changes in oxidative stress, selenium (Se) and zinc (Zn), and health-related quality of life (HRQoL) following COVID-19 vaccination. Materials and methods: 20 healthy male subjects received 2 doses of inactivated COVID-19 vaccines between January and August 2021. Peripheral blood samples were taken immediately before the 1 st dose and 3 days after the 2 nd dose of the vaccine. The oxidant status (malondialdehyde (MDA) and total oxidant status (TOS)), antioxidant status (superoxide dismutase (SOD) and total antioxidant status (TAS)), Se and Zn, and HRQoL levels of the subjects were evaluated. In addition, oxidative stress index (OSI) was calculated. Results: The mean age and body mass index of the subjects were 45.85 +/- 6.38 years and 28.53 +/- 4.50 kg/m(2), respectively. Following COVID-19 vaccinations, TAS levels decreased (p = 0.004); however, SOD levels increased (p = 0.012) significantly. In addition, there were no significant changes in TOS and MDA levels (p > 0.05). Moreover, OSI showed no significant differences (p > 0.05). After the vaccination process, Se and Zn increased; however, the differences were insignificant (p > 0.05). In addition, the HRQoL of the subjects did not change (p > 0.05). Conclusion: Although the antioxidant status decreased after 2 doses of COVID-19 vaccination, the oxidant status and the oxidative stress levels of the subjects remained stable. Thus, 2 doses of inactivated COVID-19 vaccination may have no effects on oxidative stress levels in healthy males. In addition, there were no changes in the serum concentrations of Se and Zn. Moreover, there was no difference in the HRQoL of the subjects. Therefore, COVID-19 vaccination process may not affect serum Se and Zn levels and HRQoL in healthy males.
dc.identifier.doi10.5414/TE500067
dc.identifier.endpage71
dc.identifier.issn0946-2104
dc.identifier.issue3
dc.identifier.scopusqualityN/A
dc.identifier.startpage64
dc.identifier.urihttps://doi.org/10.5414/TE500067
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2189
dc.identifier.volume41
dc.identifier.wosWOS:001227543500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherDustri-Verlag Dr Karl Feistle
dc.relation.ispartofTrace Elements and Electrolytes
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectSARS-CoV-2
dc.subjecttrace element
dc.subjectSe
dc.subjectZn
dc.subjectquality of life
dc.titleLevels of oxidative stress, selenium and zinc, and health-related quality of life in healthy males before and after COVID-19 vaccination
dc.typeArticle

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