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Öğe Eagle Strategy Based on Modified Barnacles Mating Optimization and Differential Evolution Algorithms for Solving Transient Heat Conduction Problems(2021) TURGUT, O. E.; TURGUT, MertAbstract: Solving time-dependent heat conduction problems through a conventional solution procedure of iterative root-finding method may sometimes cause difficulties in obtaining accurate temperature distribution across the heat transfer medium. Analytical root-finding methods require good initial estimates for finding exact solutions, however locating these promising regions is some kind of a black-box process. One possible answer to this problem is to convert the root-finding equation into an optimization problem, which eliminates the exhaustive process of determining the correct initial guess. This study proposes an Eagle Strategy optimization framework based on modified mutation equations of Barnacles Mating Optimizer and Differential Evolution algorithm for solving one-dimensional transient heat conduction problems. A test suite of forty optimization benchmark problems have been solved by the proposed algorithm and the respective solution outcomes have been compared with those found by the reputed literature optimizers. Finally, a case study associated with a transient heat conduction problem have been solved. Results show that Eagle strategy can provide efficient and feasible results for various types of solution domains.Öğe Greater Socioeconomic Disadvantage as Measured by the Area Deprivation Index Is Associated With Failure of Healing Following Arthroscopic Repair of Massive Rotator Cuff Tears but Not With Clinical Outcomes(W.B. Saunders, 2024) Ardebol J.; Kılıç, Ali İhsan; Pak T.; Menendez M.E.; Denard P.J.Purpose: To analyze the relationship between Area Deprivation Index (ADI) and preoperative status and short-term postoperative clinical outcomes among patients who underwent arthroscopic rotator cuff repair (ARCR) of massive rotator cuff tears (MRCTs). Methods: A retrospective review was conducted on prospectively maintained data on patients who underwent ARCR of MRCTs defined as tear size ?5 cm or complete tear of at least 2 tendons, with a minimum 2-year follow-up and a valid home address between January 2015 and December 2018. Each patient's home address was mapped to the ADI to determine neighborhood disadvantage. This composite index is composed of 17 census-based indicators, including income, education, employment, and housing quality to quantify the level of socioeconomic deprivation. Ratings were recorded and categorized based on the sample's percentile. Patients were then divided into 2 groups: upper quartile (ie, most disadvantaged [?75th percentile]) and lower 3 quartiles (ie, least disadvantaged [<75th percentile]). Bivariate analysis was performed to associate ADI with patient-reported outcomes (PROs) and range of motion pre- and postoperatively, as well as complications, healing rate, satisfaction, and return to work. Patients reaching or exceeding the minimal clinically important difference for visual analog scale (VAS), American Shoulder and Elbow Surgeons, Veterans Rand 12-Item questionnaire, and subjective shoulder value were recorded for both cohorts. Results: Ninety-nine patients were eligible for study analysis. Preoperative PROs and range of motion were similar, except for a greater VAS for pain (6.3 vs 4.3; P < .01) and lower American Shoulder and Elbow Surgeons score (32.2 vs 45.1; P = .01) in the most disadvantaged group. Both groups showed similar postoperative PROs scores, but greater VAS improvement was seen in the upper quartile group (? 4.2 vs ? 3.0; P = .04). In contrast, only the least-disadvantaged group significantly improved in internal rotation (P = .01) and forward flexion (18°; P < .01) from baseline. Although satisfaction, complications, and return to work were comparable (P > .05), failure of healing occurred more frequently in the most disadvantaged group (21% vs 6%; P = .03). Conclusions: Patients with MRCTs residing in the most disadvantaged neighborhoods as measured by the ADI have more pain and functional limitations before undergoing ARCR but demonstrate similar postoperative functional improvements to patients from other socioeconomic backgrounds. Failure of healing of MRCTs may be more common in disadvantaged groups. Furthermore, both groups reported similar rates of clinically important functional improvement. Level of Evidence: Level III, retrospective cohort comparison. © 2023 Arthroscopy Association of North AmericaÖğe Ultrasound vs. fluoroscopic guidance in genicular nerve radiofrequency thermocoagulation for chronic knee pain: which one is the future?(Verduci Publisher, 2023) Dagistan, G.; Gonullu, E.OBJECTIVE: Fluoroscopic guiding is commonly utilized for interventional pain management procedures. However, ultrasonography has started to be used more widely in interventional pain procedures. It has become even more popular with its advantages. The clinician who performs the pain procedure and the patient are not exposed to radiation. Vascular structures can be directly visualized. Ultrasonography is more accessible and portable than fluoroscopy. For all these reasons, its use will increase. So, in this study, we aimed to compare the efficacy of the genicular nerve radiofrequency thermocoagulation application under ultrasound guidance and fluoroscopy guidance.PATIENTS AND METHODS: Patients with stage 2 and 3 osteoarthritis, according to the Kellgren-Lawrence classification, were included in our study (n=180). Seventy percent of patients were women. Sixty patients received medical treatment only. Genicular nerve radiofrequency thermocoagulation was performed with fluoroscopy in sixty patients and with ultrasonography guidance in sixty other patients. Visual Analogue Scale at 1 month (VAS1) and Western Ontario and McMaster Universities Arthritis (WOMAC1) were recorded before the procedure, while VAS2 and WOMAC2 were recorded at 3 months.RESULTS: In the ultrasound and fluoroscopy group, a statistically significant difference was found between VAS1 and VAS2, WOMAC1 and WOMAC2 (p<0.05). VAS1 of the patients in the fluoroscopy group was 6.65 +/- 0.93, and it was 5.88 +/- 0.92 in the ultrasonography group, which was similar (p<0.0001). VAS2 was 2.26 +/- 1.16 in the ultrasonography group and 3.83 +/- 1.66 in the fluoroscopy group (p<0.0001). The reduction rate in pain severity in patients undergoing the procedure under ultrasonography guidance was more marked than that in the fluoroscopy group (p<0.0001).CONCLUSIONS: For the radiofrequency thermocoagulation of the genicular nerve, both imaging approaches are available. Ultrasonography guidance appears to be better than fluoroscopy guidance in this technique because of the lower radiation dose and the ability to detect the target location and neighboring tissues more precisely under ultrasonography guidance.Öğe A retrospective study: the effect of sensitization events on anti-HLA antibody development(Wiley, 2023) Gulec, Rasime Derya; Arslan, Fatma Demet[Abstract Not Available]Öğe Protective Effect of Sirtuin 2 Inhibition in D-Galactose-Induced Renal Aging and Fibrosis(Wiley, 2023) Keskin-Aktan, Arzu; Bahar, Asli Nur; Dizakar, Saadet Ozen Akarca; Akbulut, Kazime Gonca[Abstract Not Available]Öğe AGK-2 Protects the Tymus Aganist D-Galactose Induced Senescense in Rats(Wiley, 2023) Bahar, Asli Nur; Kavak, Hatice; Keskin-Aktan, Arzu; Dizakar, Saadet Ozen Akarca; Coskun, Ayca; Akbulut, Kazime Gonca[Abstract Not Available]Öğe The Role of Adropin in Metabolic Syndrome and Cardiac Remodeling(Wiley, 2023) Yesil, Ahmet Hulusi; Ozer, Cigdem; Dizakar, Saadet Ozen Akarca[Abstract Not Available]Öğe Predicting adverse perinatal outcomes with fetal modified myocardial performance index and epicardial fat tissue thickness in diabetes-complicated pregnancies(Verduci Publisher, 2023) Omeroglu, I.; Golbasi, H.; Bayraktar, B.; Golbasi, C.; Karaca, S. Yildirim; Demircan, T.; Ekin, A.OBJECTIVE: The aim of this study was to evaluate fetal modified myocardial performance index (mod-MPI) and fetal epicardial fat tissue (EFT) thickness and its association with adverse perinatal outcomes in diabetic pregnant women.PATIENTS AND METHODS: This was a prospective case-control study including 90 gestational diabetes mellitus (GDM) and 45 pregestational diabetes mellitus (PGDM) and 90 healthy pregnant women (control group). Two-dimensional gray-scale and Doppler fetal echocardiography were used to calculate the mod-MPI. EFT thickness was measured in the hypoecho-genic area between the myocardium and the visceral pericardium on the right ventricle by distinguishing it from the pericardial fluid by Doppler ultrasound. RESULTS: Both mod-MPI values and EFT thickness were significantly higher in diabetic pregnant women (p<0.001; for both). No significant differences were observed in mod-MPI values and EFT thickness between pregnant women with GDM and PGDM. In addition, there was no significant difference in fetal mod-MPI values and EFT thicknesses among diabetic pregnant women based on their treatment requirements. The receiver operating characteristic (ROC) curve revealed that mod-MPI value (cut-off 0.54, 95% CI: 0.629-0.837, p<0.001, sensitivity 64.6%, specificity 61.7%) and EFT thickness (cut-off 1.85 mm, 95% CI: 0.524-0.750, p=0.014, sensitivity 65.8%, specificity 63.9%) could predict adverse neonatal outcomes in diabetic pregnant women. Multivariate regression analysis revealed that both mod-MPI (p=0.003) and EFT thickness (p=0.008) were independently associated with adverse outcomes.CONCLUSIONS: Fetal mod-MPI values and EFT thickness increase in pregnancies complicated by diabetes, and these measurements may serve as valuable predictors of adverse perinatal outcomes.Öğe Biomechanical Effects of Angiotensin 1-7 in Diabetes Rats Femur(Soc Chilena Anatomia, 2023) Nalbant, Asrın; Dalaman, Uğur; Gök, Kadir; Duygu, Özden Bedre; Yaras, Nazmi; Kavak, ServetIt is known that diabetes mellitus has late complications, including microvascular and macrovascular diseases. Diabetes can affect bones through biochemical markers of bone structure, density, and turnover. This study aimed to biomechanically investigate the bone-protective effects of angiotensin 1-7 (Ang 1-7), one of the active peptides in the renin-angiotensin system, in rats with diabetes. Thirty male Wistar albino rats, three months old and weighing 250-300 g, were divided into four groups: diabetes, Ang 1- 7, diabetes plus Ang 1-7, and control. One month later, diabetes developed in rats; the rats were sacrificed, and their right femur was removed. Three-point bending biomechanical tests were performed on the femurs. The diabetic group had significantly higher bone fragility than the other groups (Pr >.05). Bone fragility was lower, and bone flexibility was higher in the Ang 1-7 groups (Pr>F value 0.05). As a result of our study, the effect of Ang 1-7 on the bones of rats with diabetes was investigated biomechanically. Ang 1-7 has a protective impact on the bones of rats with diabetes.Öğe Serum nitric oxide levels are depleted in depressed patients treated with electroconvulsive therapy(Wolters Kluwer Medknow Publications, 2021) Atagün, Murat İlhan; Atay, Özge Canbek; Balaban, Özlem D.; İpekçioğlu, Derya; Alpugan, Barış; Yalçın, Suat; Senat, AlmilaBackground: Nitric oxide (NO) is an endogenous substance which has several endocrine functions and may act as neurotransmitter in the brain. High levels of NO may provoke nitrosative stress. Aim: It was aimed to examine serum levels of NO in patients with depressive episodes who were treated with electroconvulsive therapy (ECT) in this study. Methods: The design was a case-control, follow-up study. Patients with depressive episodes (n = 23) and a healthy control group (n = 21) were enrolled. Three serum samples were obtained from the patient group (before ECT, after first and seventh sessions). NO, nitrite, and nitrate levels were examined. Statistical Analysis: Differences between groups were examined with t-test or Mann-Whitney U-test. Longitudinal data were evaluated with Panel Regression Analysis and Kruskal-Wallis Test. Results: Serum levels of NO and nitrite decreased significantly after the seventh session of ECT administration compared to the baseline and first session. Nitrate levels did not differ between the assessments. Conclusions: Reduction of the serum NO and nitrite levels might be a contributing factor for hypertension during the sessions. These findings are reflect the circulating NO levels. Further studies may dissect NO physiology in the brain in mental disorders and potential external effects.Öğe Radiographic Morphometry of the Distal end Radius in Anatolian Population(Soc Chilena Anatomia, 2023) Nalbant, Asrin; Ismailoglu, Eren; Turhan, Ebru; Duygu, Ozden BedreDistal radius fractures are one of the most common orthopedic injuries encountered by orthopedic surgeons.. Correction of dorsal tilt and radial height is essential to restore normal biomechanics of the wrist joint. Comprehensive knowledge of the morphometry of the distal radius of the local population becomes critical for the treating surgeon. This study aims to report the morphometry of the distal radius in the Anatolian population and compare it with similar studies in other races and humans. Radiographs of one hundred and twenty-four people were included in the study. Four radiological parameters were examined on all radiographs: radial height, radial tilt, ulnar variance, and palmar tilt. Radial tilt was 23.35 degrees +/- 1.96; palmar tilt was 15.7 degrees +/- 2,87 radial height (mm) was 10.55 +/- 4.34, ulnar variance (mm) was 0.32 +/- 1.79. The highest rate of negative ulnar variance was found. According to the study's results, reference data varying by race for anatomical fit should be considered in treating DER injuries.Öğe The Effect of White Noise and Brahms' Lullaby on Pain in Infants during Intravenous Blood Draw: A Randomized Controlled Study(Innovision Professional Media, 2023) Midilli, Tulay Sagkal; Ergin, EdaObjective . This study investigates the effects of white noise and Brahms' lullaby in managing pain in infants who were administered with intravenous blood draws in a pediatric blood-sampling unit. Design . This study was an experimental, randomized controlled trial. Setting . This study was conducted on 0-12-month-old infants admitted to a pediatric blood-sampling unit of a university hospital in Turkey between July and October 2019. Participants . The sample comprised 59 infants 0-12 months of age. The infants were randomly assigned to three groups: (a) white noise, (b) Brahms' lullaby, and (c) control. Outcome measures . We evaluated the pain of the infants according to the Neonatal Infant Pain Scale (NIPS). We measured their pain and crying time before, during, and after the procedure. Results . The means of the NIPS scores of the infants in the white noise and Brahms' lullaby groups were lower than that of the control group before, during, and after the procedure. The means of the NIPS scores of the infants in the white noise and Brahms' lullaby groups were significantly lower than that of the control group during and after the procedure (P <.05). The crying time of the infants in the white noise and Brahms' lullaby groups were significantly lower than that of the control group after the procedure (P <.05). Conclusion . The white noise and Brahms' lullaby used during the intravenous blood draw procedure reduced the pain of infants. (Altern Ther Health Med. 2023;29(2):148-154)Öğe Parameter estimation of the wind speed distribution model by dragonfly algorithm(Gazi Univ, Fac Engineering Architecture, 2023) Kose, Bayram; Aygun, Hilmi; Pak, SemihPurpose: In modelling wind speed by Weibull probability distribution function (Wpdf) for potential calculation of wind energy and wind speed characterization, the purpose of the study is to estimate the distribution parameters.Theory and Methods: The performance of the proposed method has been evaluated by comparing not only the classical methods which are the moment method (MM) and the least squares method (LSM) but also metaheuristic optimization algorithms which are Dragonfly Algorithm (DA), Genetic Algorithm (GA) and Particle Swarm Optimization (PSO). Determination coefficient (R2) and root mean square error (RMSE) were used to evaluate the performance of these parameter estimation methods. Results: Dat obtaine from 6 measurement stations were used in the study. The results show that while the DA method gives the best performance according to the determination coefficient (R2) criterion in all stations, it provides the best performance in 2 stations according to the root mean square error (RMSE) criterion. In addition, it was observed that the DA method showed better performance in all stations compared to the LSM method.Conclusion: It is seen that the proposed DA algorithm for wind energy potential calculation can be used to estimate Weibull and two-component mixed Weibull distribution parameters.Öğe Effect of SIRT2 Inhibition on Developing Fibrosis in D-GalactoseInduced Aging Model(Wiley, 2023) Bahar, Asli Nur; Aktan, Arzu Keskin; Sonugur, Fatma Gizem; Dizakar, Saadet Ozen Akarca; Akbulut, Kazime Gonca[Abstract Not Available]Öğe The influence of intra-venous glucose administration during in-vivo embryo production process in dairy cattle(Wiley, 2023) Okuroglu, A.; Tirpan, B.; Sevgi, R.; Yilmaz, M.; Unal, I.; Coskun, M.; Unay, E.[Abstract Not Available]Öğe Evaluation of The Effect of Telerehabilitation on Neuroplasticity in Patients with Multiple Sclerosis by Neuropsychometric Tests and EEG Spectral Analysis(Sage Publications Ltd, 2023) Kabay, Sibel Canbaz; Guler, Merve; Sahin, Nilay Yurekdeler; Kaya, Gozde; Benli, Tuba Kaya; Tas, Melike; Tosun, Mustafa[Abstract Not Available]Öğe Nurses' Use of Holistic, Complementary and Alternative Medicine Methods Against COVID-19 Anxiety(Innovision Professional Media, 2023) Ergin, Eda; Ozbolat, GulizContext . Health professionals have been experiencing physical and mental fatigue, affective disorders, and sleep problems due to the stress experienced during the COVID-19 pandemic. As in most outbreaks and pandemics, nurses are at the forefront of the fight against the coronavirus and have experienced high anxiety levels. People can resort to many methods of coping with stressful situations, including complementary and alternative medicine (CAM). Objective . The study intended to assess nurses' anxiety levels about COVID-19 during the peak period of its second wave in Turkey and to examine the methods that they used to cope with that anxiety as well as their attitudes toward CAM. Design . The research team designed a descriptive and cross-sectional study Setting . The study was conducted in a training and research hospital in the Aegean region of Turkey between February 2021 and May 2021, during the second wave of the COVID-19 pandemic. Participants . Participants were 168 nurses working in the hospital. Outcome Measures . Data were collected with the Sociodemographic Information Form, Coronavirus Anxiety Scale (CAS), and Holistic Complementary and Alternative Health Questionnaire (HCAMQ), which has two subdimensions, CAM and Holistic Health (HH). Results . A significant relationship was found between the unit where the nurses worked and their scores on the CAM subdimension (P <.037). A significant relationship was also found between the nurses' anxiety about the COVID-19 epidemic and the scores on the holistic health (HH) subdimension (P <.001) and the HCAMQ (P <.016). To cope with anxiety, the nurses who experienced anxiety used the following complementary methods: (1) saying prayers and worshipping (56.6%), (2) taking hot and cold showers (54.6%), and (3) drinking herbal teas and infusions (49.3%). A weak correlation was found between the CAS, CAM, and HCAMQ scores (P <.05). Conclusions . The current study found that it could be beneficial for nurses to apply complementary methods to reduce their anxiety, because it's not known how long the COVID-19 pandemic will continue. In line with these results, it's extremely important to determine the psychological symptoms and to determine the priorities for solving these problems in nurses. Therefore, it's recommended that nurses should identify their anxieties about COVID-19 and that they should use complementary methods to manage their anxieties.Öğe INCIDENCE AND RISK FACTORS FOR LOW LEVEL VIREMIA IN CHRONIC HEPATITIS B PATIENTS RECEIVING ANTIVIRAL TREATMENT(Lippincott Williams & Wilkins, 2023) Hasanoglu, Imran; Guner, Hatice Rahmet; Zerdali, Esra Yerlikaya; Tosun, Selma; Onlen, Yusuf; Yildirim, Figen; Turunc, Tuba[Abstract Not Available]Öğe Clinical value of Tc-99m MIBI Myocardial Gated SPECT in children and adolescents presenting with exercise related chest pain(Springer, 2023) Alakbarli, A.; Karacan, M. A.; Sevinc, Y. Ozananar; Ceylan, Y.; Argon, M.; Ozcan, Z.[Abstract Not Available]Öğe Prognostic Significance of the Strong Ion Gap in Patients in Medical and Surgical Intensive Care Units(Springernature, 2023) Altun, Halil Ibrahim; Altun, Gozde; Altas, Omer Faruk; Aran, GulcinBackgroundThis study aimed to analyze acid-base imbalance by assessing the arterial blood gas (ABG) samples of the medical and surgical intensive care unit (ICU) patients by the Stewart approach and demonstrate the advantages of this method in delineating the acid-base status in cases where Henderson-Hasselbalch, anion gap, and base excess cannot optimally depict the imbalance and create recognition in the clinicians in this regard.MethodologyAdult (i.e., age > 18 years) patients admitted to the ICU of our institution during a one-year study period were included in this study. The patients were divided into two groups based on the indication of admission to the ICU as medical or surgical. The ABG, sodium, potassium, calcium, magnesium, phosphate, chloride, albumin, lactate, hemoglobin, hematocrit, leukocyte, blood urea nitrogen, and creatinine values determined during the first 24-hour period were used for calculating the Acute Physiologic Assessment and Chronic Health Evaluation (APACHE II), strong ion difference apparent (SIDa), and SID effective (SIDe) scores, which were subsequently compared between the groups.ResultsOverall, 220 (110 medical and 110 surgical) patients were included. The mean patient age was 63.56 +/- 18.08 years. The mean APACHE II scores were 21.99 and 19.63 in the medical and surgical groups, respectively. Overall, 110 patients died, while 110 were referred to the regular patient floor. The mean APACHE II score of the patients who died was 28.3, and the latter group had a mean APACHE II score of 13.57. There was a significant difference between the surgical and medical patient groups regarding mean values of APACHE II, SIDa, and SIDe scores. Also, the differences were significant between the patients who died and were discharged. There was a significant difference between the patients who died and were discharged regarding the strong ion gap (SIG); however, the medical and surgical patient groups were not different concerning the SIG values.ConclusionsWe conclude that SIDa, SIDe, and SIG can be used in medical and surgical ICU patients to predict prognosis.
