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Öğe The effect of radiological phenotypes on survival of chronic obstructive pulmonary disease(İzmir Göğüs Hastalıkları Hastanesi, 2024) Deniz, Sami; Yılmaz, Emine Sena Dikmentepe; Erbaycu, Ahmet EminIntroduction and Aim: Emphysema, chronic bronchitis and bronchiectasis are the predominant phenotypes seen in chronic obstructive pulmonary disease (COPD) and may develop at different rates over time. The aim of the study was to investigate the effects of these three radiological phenotypes on survival in patients with COPD. Materials and Methods: The study was designed as retrospective and cross-sectional. Patients with stable COPD who applied between 2015 and 2019 and whose thorax high-resolution computed tomography were diagnosed with one of the three phenotypes radiologically were included in the study. A total of 90 male patients, 30 of whom had bronchiectasis, 30 had emphysema, and 30 had chronic bronchitis, were included. Age, body mass index, spirometry measurement values, blood tests, time of diagnosis, time of death, comorbidities and demographic data of the patients were recorded. Results: There was no statistical difference between the three groups in terms of age, baseline laboratory and spirometry values, except for FEV1/FVC. The FEV1/FVC ratio was found to be lower in emphysema-predominant COPD than in the other two phenotypes (p=0.023). While comorbidities such as hypertension, diabetes, and chronic heart failure were at a similar frequency between the three groups, coronary artery disease was found to be significantly higher in the emphysema group (p=0.030). The shortest survival was determined in chronic bronchitis and emphysema-predominant COPD, and the longest in the bronchiectasis-predominant COPD group (p=0.037). Conclusion: The phenotypes of chronic bronchitis, emphysema, and bronchiectasis in patients with COPD are similar in baseline values such as age, laboratory tests, body mass index, and spirometry measurements, excluding FEV1/FVC ratio. These three phenotypes are associated with a high rate of comorbidity, primarily cardiac. The shortest lifespan is in the chronic bronchitis and emphysema phenotype, and the longest in the bronchiectasis phenotype.Öğe An Application on Chest X-Ray Images for the Detection of Tuberculosis Disease by Employing Deep Convolutional Neural Networks(İzmir Bakırçay Üniversitesi, 2023) Koç, Hatice; Hızıroğlu, Kadir; Erbaycu, Ahmet EminTuberculosis is the second infectious disease causing death after COVID-19. Diagnosing it is an easy and cheap via chest radiographs. However, some countries lack medical personnel and equipment for tuberculosis detection on chest radiographs. Computer-aided diagnosis and computer-aided detection systems utilizing deep learning can be employed to identify tuberculosis on medical images. Although there are some studies, they are insufficient for unbiased systems because these systems require the datasets having different features. The aim of this study is to evaluate the performance of pretrained networks for a classification application on chest X-ray images by utilizing the dataset from the Hospital in Turkey and Montgomery Count Dataset. The predictive models were implemented with the pre-trained DCNNs such as ResNet-50, Xception, and GoogLeNet. An Xception model provides the best performance.Öğe Quality of life and somatic physical function of patients with colorectal cancer who underwent oxaliplatin-based systemic chemotherapy: a prospective study(Springer, 2024) Tuğral, Alper; Kebabçı, Eyup; Aribas, Zeynep; Akyol, Murat; Can, Aysegul; Bakar, YeşimintroductionThis study aimed to study the potential effects of oxaliplatin-based chemotherapy on cardiorespiratory fitness, handgrip strength (HGS), body composition, and quality of life (QoL) of stages III-IV colorectal cancer (CRC) patients before the first cycle (T0) and after the last cycle of systemic adjuvant/neoadjuvant chemotherapy (T1).MethodsCardiorespiratory fitness, HGS, body composition, and QoL were evaluated with the six-minute walk test (6MWT), hydraulic hand dynamometer, body composition analyzer, and Functional Assessment of Cancer Therapy-Colon (FACT-C) questionnaire in both T0 and T1, respectively.ResultsTwenty-eight CRC patients were included in this study. The total walked distance (TWD) was found to be decreased from T0 to T1 (499.72 m vs. 488.56 m); however, this change was not significant (z = -.706, p = 0.48). Type of chemotherapy whether adjuvant or neoadjuvant also showed no significant effect on TWD (z = -.1.372, p = .17 vs z = -1.180, p = .238, respectively). The QoL was significantly decreased (T0 = 118.35 vs T1 = 110.77, t = 2.176,p = 0.05). The TWD was significantly correlated with the physical well-being (PWB) subscale of FACT-C (r = .64, p = 0.001) as well as with HGS (r = .46, p = .018) in T0. After controlling for age, type of chemotherapy, and type of regimen, the HGS did not show a significant difference from T0 to T1 (F(1,23) = 1.557, p = .22, eta p2 = .06). However, the effect of time x gender showed significant difference from T0 to T1 (F(1,23) = 4.906, p = .037, eta p2 = .17).ConclusionThis study showed the decreased QoL and physical well-being of CRC patients who underwent oxaliplatin-based treatment. In addition, the gender effect of decreased HGS should be considered further when planning an oncological rehabilitation program.Öğe Video game exposure in children with epilepsy: EEG and clinical findings(Elsevier, 2025) Tekin, Hande Gazeteci; Edem, PinarObjective: To investigate the effects of video game exposure on pediatric epilepsy patients, focusing on electroencephalography (EEG) and clinical outcomes. Methods: A total of 94 pediatric epilepsy patients aged 6-18 years (juvenile idiopathic generalized epilepsy, childhood absence epilepsy, self-limited idiopathic focal epilepsy [SeLEAS and SeLECTS]) and 57 non-epileptic controls were enrolled. EEG recordings were obtained while patients were awake, asleep, and during video game play. The impact of video games was analyzed across different epilepsy subgroups and according to epilepsy control status. Results: Twenty-five patients with EEG deterioration in the entire group, three of whom were from the control group (p = 0.032). Among juvenile idiopathic generalized epilepsy patients, 2 of 21 controlled and 6 of 11 uncontrolled patients were adversely affected by video games (p = 0.01). In the SeLECTS group, none of the controlled patients and 3 of 11 uncontrolled patients showed adverse effects (p = 0.063). In the absence epilepsy and SeLEAS groups, epilepsy status did not significantly affect video game response (p = 0.250, p = 0.603). Patients with pattern sensitivity and photosensitivity had a higher risk of EEG deterioration during video game play than those without these sensitivities. Conclusions: Playing selected video games is safer for patients with juvenile idiopathic generalized epilepsies and the SeLECTS group when precautions are taken, and both EEG and clinical conditions are under control. However, video games pose a risk for patients with absence epilepsy and SeLEAS, regardless of epilepsy control status. These findings underscore the need for individualized assessments and tailored recommendations for video game exposure in pediatric epilepsy patients.Öğe Risk profiling of breast cancer-related lymphedema (BCRL) in patients with breast cancer via using body composition and tissue dielectric constant (TDC) method: A cross-sectional study(Cig Media Group, Lp, 2024) Tuğral, Alper; Akyol, Murat; Colakoglu, Oyku; Bakar, YeşimBreast cancer-related lymphedema (BCRL) is one of the most fearsome side effects of breast cancer treatment. Higher body mass index (BMI) is a well-known risk factor for BCRL. A total of 72 patients were included. The fat mass was significantly and linearly correlated with dielectric ratios which might be indicative of preclinical Background: Breast Cancer-Related Lymphedema (BCRL) is one of the most prominent long-term side effects of breast cancer (BC) treatment. Although an increased BMI is a well-recognized risk factor for BCRL, there is a lack of knowledge regarding the potential associations between body composition and the risk of BCRL. Therefore, this study aimed to analyze the BCRL risk profiles of surgically operated BC patients via body composition and the Tissue Dielectric Constant (TDC) method, respectively. Methods: A total of 72 patients were included. Patients' risk for BCRL was assessed with Moisture MeterD (Delfin, Finland) in 4 different probes each has unique penetration depths from 0.5 (10 mm) to 5.0 (55 mm) at both upper extremities. The body composition was analyzed with Tanita-BC-420 (TANITA, Japan). Comparing the dielectric values of extremities and proportioning to one another as TDC ratio (at-risk side/unaffected side) was used to profile BCRL risk. Results: TDC values of the thorax reference point were significantly higher in all four probes on the at-risk side ( P < .05). TDC ratios in the forearm and Thorax points were significantly correlated with fat mass (r = 0.256, P = .030; r = 0.269, P = .022) as well as with visceral fat rating (VFR) (r = 0.340, P = .003; r = 0.466, P < .001). Conclusion: This study highlights the need for further care and investigation in the assessment and prediction of BCRL by considering body composition. Since the risk reduction of BCRL can be maximized by considering the individual features, we can conclude that patients with higher body fat irrespective of the BMI should be followed up regularly.Öğe Insights from CD71 presentation and serum lipid peroxidation in myasthenia gravis - A small cohort study(Elsevier, 2024) Caglayan, Sinem Tuncer; Elibol, Birsen; Severcan, Feride; Gursoy, Esra Basar; Tiftikçioğlu, Bedile İrem; Dalar, Zeynep Gungordu; Celik, CerenMyasthenia gravis (MG) is a multifaceted autoimmune disorder affecting the postsynaptic neuromuscular junction. In this study, we examined CD4+ and CD8+ T lymphocyte levels and ratios within peripheral blood mononuclear cells (PBMCs) in MG patients. Additionally, we assessed lymphocytes for the expression of CD71, which functions as a transferrin receptor mediating the uptake of iron into the cells. Building on recent discussions regarding CD20 depletion treatments in MG, we also scrutinized lymphocytes for CD20 expression. Comparative analyses were conducted among healthy controls, newly diagnosed MG patients, those undergoing pyridostigmine treatment alone, and MG patients receiving combination therapies. In the patients, the ratio of CD3+CD4+ T lymphocytes to CD3+ T lymphocytes was found to be decreased compared to the healthy controls, while the ratio of CD3+CD8+ cells to CD3+CD4+ cells increased. An increase in the percentage of CD71expressing lymphocytes was observed in MG patients compared to the healthy control group, while CD20+ lymphocytes exhibited no statistical changes. Moreover, heightened serum lipid peroxidation levels were found in MG patients. These results suggest a possible relationship between iron metabolism, levels of CD71-expressing cells, and lipid peroxidation in MG. Conversely, pyridostigmine treatment reduced the levels of CD71-expressing cells and lipid peroxidation, suggesting potential immunomodulatory and antioxidant impacts of pyridostigmine in MG, either directly or indirectly.Öğe A multicenter retrospective study in Turkish children with myotonic dystrophy type 1(Pergamon-Elsevier Science Ltd, 2024) Tuncer, G. Oz; Sanri, A.; Bayir, G. Kurt; Erol, I.; Ardicli, D.; Ozturk, M.; Tekin, Hande Gazeteci[No abstract available]Öğe Pentablock thermoresponsive hydrogels for chemotherapeutic delivery in a pancreatic cancer model(Royal Soc Chemistry, 2025) Elsherbeny, Amr; Bayraktutan, Hulya; Gümüş, Nurcan; Mccrorie, Phoebe; Garcia-Sampedro, Andres; Parmar, Shreeya; Ritchie, Alison A.The design of biodegradable and thermoresponsive polymeric hydrogels with tuneable properties holds immense promise for localised and sustained drug delivery. In this study, we designed and synthesised a library of novel pentablock copolymers, incorporating poly(d,l-lactide) (PLA) into methoxypoly(ethylene glycol)-poly(epsilon-caprolactone)-methoxypoly(ethylene glycol) (mPEG-PCL-mPEG, or PECE) hydrogels to enhance the hydrolytic degradation and drug release profiles. A pentablock copolymer, methoxypoly(ethylene glycol)-b-poly(d,l lactide)-b-poly(epsilon-caprolactone)-b-poly(d,l lactide)-b-methoxypoly(ethylene glycol) (mPEG-PLA-PCL-PLA-mPEG, or PELCLE), was selected based on its thermoresponsive sol-gel transition behaviour at a physiologically relevant temperature (37 degrees C). Physicochemical characterisation revealed that both PECE and PELCLE hydrogels self-assembled into micellar structures, with PELCLE exhibiting smaller micellar sizes compared to PECE. The incorporation of PLA led to reduced hydrogel stiffness, enhanced degradability, and decreased swelling compared to PECE. In vitro drug release studies demonstrated that both hydrogels exhibited sustained release of various anti-cancer drugs, with PELCLE generally showing slower release kinetics, highlighting its potential for prolonged drug delivery. For potential pancreatic cancer applications, we evaluated the biocompatibility and therapeutic efficacy of PELCLE hydrogels loaded with gemcitabine and oxaliplatin (GEMOX). In vitro and in vivo studies demonstrated safety and some anti-tumour efficacy of GEMOX-loaded PELCLE compared to free drug administration, attributed to enhanced tumour retention and sustained drug release. These findings highlight the potential of the PELCLE hydrogel as a versatile and effective local drug delivery platform for the treatment of pancreatic cancer and other solid tumours, warranting further investigation towards its clinical translation.Öğe Comparison of the protective effects of silymarin and thymoquinone in the focal cerebral ischemia-reperfusion rat model(Taylor & Francis Ltd, 2024) Solmaz, Merve; Erdogan, Ender; Dasdelen, Dervis; Mogulkoc, Rasim; Vatansev, Husamettin; Akyurek, Fikret; Özbek, HanefiSilymarin and thymoquinone exert neuroprotective effects, although their combined effects in focal cerebral ischemia/reperfusion (I/R) models are unknown. We compared the effect of silymarin and thymoquinone in an I/R rat model. Wistar rats were divided into five groups: SHAM, REP (I/R), SIR (200 mg/kg silymarin+I/R), TIR (3 mg/kg thymoquinone+I/R), and STIR (200 mg/kg silymarin+3-mg thymoquinone+I/R). The rats underwent bilateral carotid artery occlusion for 30 min and neurological assessments 24 h thereafter. Apoptosis was evaluated using anti-caspase-3 and terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) assays. Astrocyte activation was determined using an anti-GFAP antibody. Total antioxidant status (TAS), total oxidant status (TOS), and trimethylamine N-oxide (TMAO) levels were measured. SHAM and REP rats had the lowest and highest neurological scores, respectively (p = 0.001). REP rats showed greater deterioration than SIR, TIR, and STIR rats. SIR, TIR, and STIR rats had fewer TUNEL and caspase-3-positive cells than REP rats (p<0.05). GFAP expression was higher in REP rats (p<0.05) than in SIR, TIR, and STIR rats (p<0.05). SIR and TIR rats showed higher TAS than REP rats (p<0.05). SIR, TIR, and STIR rats had lower TMAO values than REP and SHAM rats (p<0.05). Silymarin/thymoquinone reduces impairment, apoptosis, and astrocyte activation. Combination therapy reduces TMAO levels.Öğe DHDDS-related disease; biallelic missense novel variant causing major severity with an early-onset epilepsy and hyperkinetic movement disorder(Taylor & Francis Ltd, 2024) Gazeteci Tekin, Hande; Edem, PınarBackground: Dehydrodolichyl diphosphate synthase complex is encoded by DHDDS. De novo mutations in this gene are associated with epilepsy, movement disorders, intellectual and motor disabilities. The clinical picture is commonly identified in children and shows variations in terms of age of onset, severity, seizure types, and types of dyskinesia. Case: we present a case with a infantile- onset epilepsy and severe global developmental delay, caused by a novel, de novo homozygous variant (c.425C > T, p.Thr142Met) in DHDDS. Clinical improvement was achieved with valproate and tetrabenazine treatments in the 2-year-old male patient with drug-resistant epilepsy, hyperkinetic movement disorder and myoclonus. Conclusion: Despite being rare, DHDDS-related diseases should be considered in patients with movement disorders, seizures and global developmental delay in infancy in differential diagnosis of patients resembling neuronal ceroid lipofuscinosis or progressive myoclonic epilepsies.Öğe JAKCalc: A machine-learning approach to rationalized JAK2 testing in patients with elevated hemoglobin levels(Lippincott Williams & Wilkins, 2024) Köseoğlu, Fatoş Dilan; Karadag, Fatma Keklik; Bulbul, Hale; Alici, Erdem Ugur; Ozyilmaz, Berk; Ozdemir, Taha ResidThe demand for Janus Kinase-2 (JAK2) testing has been disproportionate to the low yield of positive results, which highlights the need for more discerning test strategies. The aim of this study is to introduce an artificial intelligence application as a more rational approach for testing JAK2 mutations in cases of erythrocytosis. Test results were sourced from samples sent to a tertiary hospital's genetic laboratory between 2017 and 2023, meeting 2016 World Health Organization criteria for JAK2V617F mutation testing. The JAK2 Somatic Mutation Screening Kit was used for genetic testing. Machine learning models were trained and tested using Python programming language. Out of 458 cases, JAK2V617F mutation was identified in 13.3%. There were significant differences in complete blood count parameters between mutation carriers and non-carriers. Various models were trained with data, with the random forest (RF) model demonstrating superior precision, recall, F1-score, accuracy, and area under the receiver operating characteristic, all reaching 100%. Gradient boosting (GB) model also showed high scores. When compared with existing algorithms, the RF and GB models displayed superior performance. The RF and GB models outperformed other methods in accurately identifying and classifying erythrocytosis cases, offering potential reductions in unnecessary testing and costs.Öğe Acute effects of blood flow restricted aerobic exercise in type 2 diabetes mellitus(Lippincott Williams & Wilkins, 2024) Sahin, Elif; Ayaz, Teslime; Saglam, MeldaBackground: This study aimed to compare the acute effects of aerobic exercise performed with blood flow restriction (BFR), a novel method to increase exercise gains, with blood free flow (BFF) conditions in type 2 diabetes mellitus (T2DM). Methods: Fifteen individuals with T2DM performed BFF and BFR (40% of arterial occlusion pressure) cycling exercises 48 hours apart, at equal intensity (45% heart rate reserve) and duration (38 minutes). Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), blood glucose, heart rate, and muscle oxygen saturation (SmO2) were assessed before-after and during exercise sessions. Results: SBP, DBP, and MAP in the overload phase were higher in the BFR group than in the BFF group (P = .009, 0.031, and 0.013, respectively). Changes in blood pressure (triangle SBP and triangle DBP) were similar between the BFF and BFR groups (P > .05), whereas triangle MAP differed (P = .016). Changes in blood glucose levels and heart rates were not significantly different between the groups. Although SmO(2)baseline was lower in the BFR group (P = .049), SmO(2)min and SmO(2)max did not differ significantly between the BFF and BFR groups. Conclusion: The similar decrease in blood glucose levels between the groups suggests that BFR exercise is favorable in terms of hypoglycemia. The higher blood pressure observed during the BFR exercise remained within safe limits. These results suggest that people with T2DM can safely perform BFR aerobic exercises; however, further studies are required.Öğe The effects of laughter therapy on perceived stress and quality of life in women with breast cancer receiving chemotherapy a parallel-group randomized controlled pilot trial(Lippincott Williams & Wilkins, 2024) Karakaş, Hacer; Bahçeli, Pınar Zorba; Akyol, MuratBackground Women with breast cancer experience various symptoms secondary to chemotherapy that reduce their quality of life and increase their stress levels. Objective To evaluate the effects of laughter therapy on perceived stress levels and quality of life in women with breast cancer receiving chemotherapy using a parallel-group randomized controlled pilot trial. Methods Forty-two women were randomly assigned to intervention and control groups. The intervention group received 40 minutes of laughter therapy twice a week for 8 weeks. The control group received routine treatment. The women in both groups completed the Perceived Stress Scale and SF-12 Health Survey at baseline, week 5, and week 9 after randomization. Results There was a significant decrease in the mean Perceived Stress Scale scores in the intervention group compared with those in the control group at weeks 5 and 9 compared with baseline, and the difference between groups by measurement week was significant (P < .001). Women in the intervention group had higher Physical Component Summary-12 and Mental Component Summary-12 scores in weeks 5 and 9 compared with those in the control group, and there was a significant difference between groups in terms of change in the Physical Component Summary-12 and Mental Component Summary-12 mean scores over time (P < .001). Conclusion Laughter therapy is possible to use as a nursing intervention to reduce the perceived stress levels and increase the quality of life of women receiving chemotherapy for breast cancer. Implications for Practice Nurses can apply laughter therapy in the symptom management of women receiving chemotherapy.Öğe Surgical and non-surgical treatments in pleural empyema plevral ampiyemde cerrahi ve cerrahi olmayan tedaviler(Galenos Publ House, 2025) Deniz, Sami; Aksel, Nimet; Ozdemir, Ozer; Vayisoglu Sahin, Gorkem; Cimen Celik, Ezgi; Gucsav, Mutlu Onur; Guldaval, Filiz; Erbaycu, Ahmet EminObjective: Increasing number of patients are developing complicated pleural infection. We aimed at revealing the differences of treatment modalities performed in patients with empyema. Methods: Patients those had been diagnosed and treated for empyema were assessed in a retrospective design. For the definitive diagnosis of empyema, thoracentesis was made. We categorized the patients in two groups as therapeutic drainage (group 1) and open Results: A total of 360 patients, 57 of whom were women, were included. Tube drainage was applied to the patients in group 1, and therapeutic thoracentesis was applied to those not suitable for drainage. Patients who did not provide adequate drainage due to loculation were deloculated with fibrinolytic agent or video-assisted thoracoscopic surgery. In patients with advanced empyema with multiloculation andÖğe Health sciences students' perspectives on metaverse and digital technology use: cross-sectional descriptive study(BMC, 2024) Sezer, Hale; Gül, AbdulkadirBackgroundStudents' attitudes towards digital technologies affect their use of innovations in digital education. In the study, it was aimed to determine undergraduate health sciences students' views about the Metaverse and digital technology.MethodsThis study was a cross-sectional descriptive study. In the study sample, 289 health sciences students who voluntarily agreed to participate in the research and filled out the online data collection form were included. The Independent Samples T-Test, Multivariate ANOVA analysis of variance (MANOVA) and Pearson correlation analysis were used. P-values less than 0.05 were considered statistically significant.ResultsThe mean score the participants obtained from the Metaverse Scale was 53.54 +/- 9.00, indicating that their levels of knowledge and awareness about the Metaverse were high. The mean score they obtained from the Attitude Scale for Digital Technology was 135.98 +/- 21.28, which indicated that displayed positive attitudes towards digital technology. There was no significant difference between the mean scores the participants obtained from the Attitude Scale for Digital Technology and the Metaverse Scale according to their departments and years in school. There was a positive and weak relationship between the Metaverse Scale scores and Attitude Scale for Digital Technology scores.ConclusionsThe participants' knowledge and awareness levels about the Metaverse were high and they displayed positive attitudes towards digital technology. It is recommended that digital technologies should be used in planning undergraduate education and Metaverse platforms or applications in virtual classroom settings.Öğe Effect of latanoprost on choroidal thickness in patients with newly diagnosed primary open-angle glaucoma(Kare Publ, 2024) Buyukmurat, Neslihan; Karadag, Erdi; Özbek, HanefiOBJECTIVE: The purpose of this study was to assess the influence of latanoprost on choroidal thickness in patients with newly diagnosed primary open-angle glaucoma using Swept-Source Optical Coherence Tomography (SS-OCT). METHODS: The retrospective, non-randomized study comprised 40 newly diagnosed primary open-angle glaucoma patients receiving latanoprost therapy (Group 1). Additionally, 40 age- and sex-matched healthy subjects served as the control group (Group 2). Using SS-OCT, measurements of subfoveal, horizontal temporal, and horizontal nasal quadrants choroidal thickness, as well as intraocular pressure (IOP) and retinal nerve fiber layer (RNFL) thickness values, were collected at baseline and after 1 month for both groups. RESULTS: The mean age was 39.8 +/- 4.15 years (range: 18-45 years) in group 1 and 41.67 +/- 7.95 years (range: 18-45 years) in group 2 (p>0.05). The mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant prior to latanoprost therapy were 263.57 +/- 84.23 mu m, 233.05 +/- 80.08 mu m, and 219.52 +/- 83.28 mu m in the group 1 whereas 278.9 +/- 93.88 mu m, 243.8 +/- 73.37 mu m and 209.85 +/- 92.92 mu m in the group 2. After latanoprost therapy, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant changed significantly to 299.77 +/- 41.29 mu m, 269.9 +/- 43.80 mu m, and 261.32 +/- 45.60 mu m in the group 1 (p=0.02, p=0.016, and p=0.012, respectively) (Table 1). However, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant and horizontal nasal quadrant in group 2 changed not significant and was 279.25 +/- 103.37 mu m, 246.42 +/- 87.07 mu m and 203.62 +/- 106.74 mu m, respectively (p=0.4, p=0.5 and p=0.9, respectively). The mean IOP decreased significantly in group 1 (p=0.000) but did not change significantly in group 2 (p=0.153). There was no difference in RNFL thickness values at baseline and 1 st month in group 1 and group 2 (p>0.05). CONCLUSION: Topical latanoprost may increase choroidal thickness. Swept Source-OCT may contribute to our understanding of the actions of latanoprost on choroidal thickness.Öğe Prediction of anemia with thoracic computed tomography findings(Turkish Assoc Trauma Emergency Surgery, 2024) Öcal, Zeynep Ayvat; Koseoglu, Fatos DilanBACKGROUND: This study explored the potential of non-contrast thoracic computed tomography (CT) to predict anemia by correlating CT parameters with hemoglobin (Hb) levels in patients who underwent non-contrast thoracic CT for various indications. METHODS: This retrospective study included 150 patients who underwent non-contrast thoracic CT scans and complete blood counts within 24 hours at our center between January and June 2023. Exclusion criteria included acute bleeding, iron accumulation disorders, recent transfusions, pregnancy, and certain thoracic CT artifacts. Hounsfield Unit (HU) measurements were obtained from the ascending aorta, left ventricular cavity, and descending aorta, and compared with Hb and hematocrit (Htc) values. Anemia indicators such as the Aortic Ring Sign (ARS) and the Hyperdense Septum Sign (HSS) were also evaluated. RESULTS: Anemic patients (48%) exhibited significantly lower HU measurements at all three CT scan locations and higher instances of ARS and HSS compared to non-anemic patients. Notably, the presence of HSS and ARS was strongly associated with anemia. Thresholds for HU measurements corresponding to anemia were determined using receiver operating characteristic curve analysis, which also revealed strong positive correlations between HU measurements and Hb/Htc levels. CONCLUSION: The study concludes that non-contrast thoracic CT parameters, particularly HU measurements and the presence of ARS and HSS, are significantly associated with anemia. These CT indicators could serve as reliable, non-invasive markers for predicting anemia in patients, potentially aiding in the early diagnosis and management of the condition.Öğe Gender prediction using geometric morphometry with parameters of the cranium obtained from computed tomography images(Cukurova Univ, Fac Medicine, 2024) Secgin, Yusuf; Öner, Zülal; Öner, Serkan; Toy, SeymaPurpose:The gender difference of the cranium skeleton is of great importance in forensic anthropology and forensic medicine sciences. This study is based on this hypothesis and the gender prediction rate was obtained by processing cranium images obtained from computed tomography (CT) using geometric morphometry.Materials and Methods:CT images of 200 individuals between the ages of 25 and 65 were used in our study. The images were opened at the personal workstation Horos Medical Image Viewer (Version 3.0, USA) program and processed with 3D Curved Multiplanar Reconstruction (MPR). The line passing through the nasion and inion points of the images obtained as a result of the process was determined, and all images were brought to the orthogonal plane. Later, the images were overlapped and saved in JPEG format with 100% magnification. JPEG images saved were converted into TPS format, and 21 homologous landmarks were placed. Generalized Procrustes Analysis (GPA) and Principal Component Analysis (PCA) were applied to thecoordinates of landmarks, and shape variations and dimensionality were corrected by gathering the images to the center of gravity. Next, Linear Discriminant Analysis (LDA) was applied to the coordinates, the dimensionality of which was corrected. Results:The study found that 74.465% of the coordinates of 21 homologous landmarks gathered to the center of gravity could be explained with the first three PCs. As a result of the LDA applied to these coordinates, a gender prediction rate of 86.5% was obtained.In addition, a slight difference was found between the GPA sum of squares and the tangent sum of squares (0.57). Conclusion:The images of the cranium obtained from CT showed a high dimorphism by geometric morphometry analysisÖğe What awaits us after Covid-19? musculoskeletal system involvement in the elderly population in Turkey and its aftermath(Turkish Geriatrics Soc, 2024) Gokce-Kutsal, Yesim; Ordu-Gokkaya, Nilufer Kutay; Karahan, Sevilay; Irdesel, Fatma Jale; Paker, Nurdan; Ay, Saime; Binay-Safer, VildanIntroduction: Although COVID-19 primarily affects the respiratory system, one of the most frequently effected areas is the musculoskeletal system. COVID-19 associated musculoskeletal problems can cause disability in patients >= 65 years. The aim of the study was to define the musculoskeletal problems after the COVID-19 infection and to examine the relationship with the accompanying comorbidities in geriatric population. Materials and Method: The study was conducted by the members of Geriatric Rehabilitation Study Group of Turkish Physical Medicine and Rehabilitation Society at 11 different hospitals from 7 provinces (Ankara, stanbul, zmir, Gaziantep, Adana, Bursa, and Kirikkale) of Turkiye. Individuals aged 65 years and over who had a history of COVID-19 within the last 12 months and experienced persistent/continuous musculoskeletal complaints were included into the study. COVID-19 diagnoses were confirmed from electronic hospital records and the e-Nabiz system. Data were collected by face-to-face interviews and after recruiting the first 50 patients from each center, patient recruitment was terminated. Results: A total of 457 cases in which all questions were answered completely (without any missing data) were included in this observational study. The cases were mainly 65-75 years old, married, and non-smoking women. The most common musculoskeletal involvement was widespread pain (81%), followed by myalgia (63.7%) and arthralgia (44.4%). Other rare involvements (osteonecrosis, myositis, steroid myopathy, arthritis) were significantly more frequent in patients older than 75 years, regardless of gender. Analysis showed that musculoskeletal pain immediately after infection is observed more in cases with comorbid diseases (p<0.001), hypertension (p<0.001), pulmonary involvement (p=0.002) and hospitalization due to COVID-19 (p<0.001). It was determined that the incidence of pain seen immediately after infection increased as the number of comorbidities increased (p<0.001). In conjunction with this, persistent pain after COVID-19 infection were more common in those with osteoarthritis (p=0.039). Conclusion: Elderly patients may develop musculoskeletal pain in multiple body sites after COVID-19, which is primarily related to presence and number of comorbidities, hospitalization and pulmonary involvement. The long-term consequences of COVID-19 on musculoskeletal health are still being studied, and further research is needed to fully understand the extent and duration of these effects.Öğe Relationship between HALP and PNI score with 1-month mortality after CABG(Frontiers Media Sa, 2024) Koyuncu, İlhan; Koyun, EminBackground: Coronary heart disease (CHD) is the most common cause of cardiovascular disease (CVD). CHD is among the most common causes of mortality and morbidity world wide. In addition, CHD is one of the most important causes of health expenditures world wide. Today, coronary artery bypass grafting (CABG) operations are a widely used surgical procedure and have an important place in the treatment of CHD. Many scoring systems have been evaluated to estimate the risk of mortality and morbidity. 30-day mortality rates after CABG have been reported as 1-4% in large-scale studies. Objectives: The aim of our study was to evaluate the relationship between 1-month mortality in patients undergoing CABG and the Hemoglobin, albumin, lymphocyte, platelet index (HALP score) and Prognostic nutritional index (PNI) calculated using laboratory data in the preoperative period. Methods and design: A total of 239 patients who underwent CABG were evaluated retrospectively. Preoperative biochemical and hemogram values, demographic characteristics, comorbidities, HALP score and PNI values of the patients were recorded. The patients were divided into two groups: Exitus group (n = 51) and survival group (n = 188). The data of the two groups were compared, mainly HALP score and PNI. Results: It was observed that 51 of 239 patients (21.3%) developed exitus during the 30-day follow-up after CABG. When demographic data are compared; advanced age, female gender, history of DM (Diabetes Mellitus), history of HL (hyperlipidemia) and smoking were found to be associated with mortality. When laboratory data are compared; high troponin levels, low hemoglobin, low lymphocyte and low albumin levels were found to be associated with mortality. Low HALP score (p < 0.001) and low PNI (p < 0.001) were also found to be associated with mortality. In univariate and multivariate regression analysis; advanced age, history of DM, HALP score and PNI were found to be independent predictors of 30-day mortality after CABG. It was determined that a cut-off value of 0.29 for the HALP score and 39.1 for PNI had found, respectively, 81 and 79% sensitivity and 82 and 80% specificity. Conclusion: Preoperatively measured HALP score and PNI can be used to predict 1-month mortality after CABG.
