Fizyoterapi ve Rehabilitasyon Bölümü Koleksiyonu

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https://hdl.handle.net/20.500.14034/40

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Investigation of the relationship between academic self-efficacy, problem solving skills and self-esteem in decision making and decision-making styles of university students studying in the field of health
(Hacettepe Üniversitesi, 2022) Seçer, Erhan; Korucu, Tuğçe Şirin; Uzunlar, Hilal; Dinç, Güldane; Kaya, Derya Özer
Objective: This study was conducted to examine the relationship between academic self-efficacy and problem-solving skills with self-esteem in decision-making and decision-making styles of university students studying in the field of health. Material and Method: Two hundred and thirty one university students (mean age 21.45±1.67 years) studying in the field of health were included in the study. Students' academic self-efficacy levels were evaluated by the Academic Self-Efficacy Scale; problem-solving skills were evaluated by the Problem Solving Inventory; self-esteem in decision making and decision-making styles (careful, avoidant, postponer and panic decision making) were evaluated by the Melbourne Decision-Making Scale.Results: There was a low positive correlation was found between students' Academic Self-Efficacy Scale total scores and self-esteem and careful decision making; a low negative correlation was found between avoidant, postponer and panic decision making (r=.321, p<.001; r=.276, p<.001; r=-.234, p<.001; r=-.234, p<.001; r=-.203, p<.001, respectively). Also, there was a moderate negative correlation was found between students' Problem Solving Inventory total scores and self-esteem and careful decision making; a moderate positive correlation was found between avoidant, postponer and panic decision making (r=-.565, p<.001; r=-.569, p<.001; r=.416, p<.001; r=.507, p<.001; r=.444, p<.001, respectively). Conclusion: It was observed that academic self-efficacy and problem-solving skills were associated with self-esteem in decision making and decision-making styles of university students studying in the field of health. Accordingly, it is recommended to examine the effects of these characteristics of students on each other in prospective studies with a high level of evidence.
Does smart phone usage in young adults have an effect on static and dynamic balance?
(Hacettepe Üniversitesi, 2024) Özdemir, Kadirhan; Dönmez, Batuhan; Zeren, Melih; Şahin, Nilay Yürekdeler; Karakurum, Eshan; Eroğlu, Rumeysa
Objectives: This study aimed to investigate the effects of talking and note-taking on a smartphone on static and dynamic balance. Materials and Methods: In the study, healthy young adults (n=36) were asked to maintain postural balance while standing on static and dynamic platforms in different tasks: (Task I) without using a smartphone, (Task II) while taking notes on a smartphone, and (Task III) while talking on a smartphone. Center of pressure (CoP) on mediolateral (CoPx) and anteroposterior (CoPy), CoP path length, CoParea, and trunk deviation length were used to measure static and dynamic postural balance. Results: On a static platform, CoPy and CoParea were different between the tasks (p<0.001, p=0.017). Task II and Task III impaired CoPy more than the task I (p<0.001, p=0.004). Task III affected CoParea more negatively than task II (p=0.027). CoP path length was lower in task II and task III (p<0.001). CoP path length was significantly higher in task III compared to task II (p<0.001). On a dynamic platform, there were differences in CoPy between the tasks (p=0.038). There was a difference in CoPy between task II and task III (p=0.005). The CoParea was significantly different between the tasks (p=0.023). CoParea and CoP path length was higher in task II compared to task I (p=0.035, p<0.001). Conclusion: The study showed that smartphone use during specific tasks, including talking and/or note-taking on a smartphone, could increase the risk of falls and accidents by affecting center of pressure and postural sway.
Quality of life and somatic physical function of patients with colorectal cancer who underwent oxaliplatin-based systemic chemotherapy: a prospective study
(Springer, 2024) Tuğral, Alper; Kebabçı, Eyup; Aribas, Zeynep; Akyol, Murat; Can, Aysegul; Bakar, Yeşim
introductionThis study aimed to study the potential effects of oxaliplatin-based chemotherapy on cardiorespiratory fitness, handgrip strength (HGS), body composition, and quality of life (QoL) of stages III-IV colorectal cancer (CRC) patients before the first cycle (T0) and after the last cycle of systemic adjuvant/neoadjuvant chemotherapy (T1).MethodsCardiorespiratory fitness, HGS, body composition, and QoL were evaluated with the six-minute walk test (6MWT), hydraulic hand dynamometer, body composition analyzer, and Functional Assessment of Cancer Therapy-Colon (FACT-C) questionnaire in both T0 and T1, respectively.ResultsTwenty-eight CRC patients were included in this study. The total walked distance (TWD) was found to be decreased from T0 to T1 (499.72 m vs. 488.56 m); however, this change was not significant (z = -.706, p = 0.48). Type of chemotherapy whether adjuvant or neoadjuvant also showed no significant effect on TWD (z = -.1.372, p = .17 vs z = -1.180, p = .238, respectively). The QoL was significantly decreased (T0 = 118.35 vs T1 = 110.77, t = 2.176,p = 0.05). The TWD was significantly correlated with the physical well-being (PWB) subscale of FACT-C (r = .64, p = 0.001) as well as with HGS (r = .46, p = .018) in T0. After controlling for age, type of chemotherapy, and type of regimen, the HGS did not show a significant difference from T0 to T1 (F(1,23) = 1.557, p = .22, eta p2 = .06). However, the effect of time x gender showed significant difference from T0 to T1 (F(1,23) = 4.906, p = .037, eta p2 = .17).ConclusionThis study showed the decreased QoL and physical well-being of CRC patients who underwent oxaliplatin-based treatment. In addition, the gender effect of decreased HGS should be considered further when planning an oncological rehabilitation program.
The effect of computerized wobble board and core stabilization exercises on balance performance and exercise capacity in patients with heart failure: A randomized controlled trial
(W B Saunders Co-Elsevier Inc, 2024) Durdu, Habibe; Demir, Rengin; Zeren, Melih; Aydin, Ertan; Gunaydin, Zeki Yuksel; Yigit, Zerrin
Objective: To investigate the effects of computerized wobble board exercise training (CWBET) and core stabilization exercise training (CSET) on balance performance, and exercise capacity in patients with heart failure (HF). Desing: Single-blind randomized controlled prospective study. Setting: Cardiology department of a local university hospital. Participants: Fifty-one patients with HF with reduced ejection fraction, whose clinical status and medication had been stable for the previous 3 months, were included (N=51). Nine patients could not complete the follow-up period due to personal reasons. No patient experienced any adverse events during exercise training. Interventions: Patients were randomized to CWBET, CSET, and control group. CWBET and CSET groups participated in their own exercise programs, 3 days a week for 8 weeks. The control group received no exercise program. Main Outcome Measures: All patients were evaluated at baseline and after 8 weeks. Postural stability, static and functional balance, and exercise capacity were evaluated with the Sensamove Balance Test Pro with Miniboard, the one-leg stance test (OLS), the Berg Balance Scale (BBS), and the six-minute walk distance (6MWD), respectively. Core stabilization and health-related quality of life (HRQOL) were assessed with OCTOcore app, and Minnesota Living with Heart Failure Questionnaire, respectively. Results: A mixed model repeated-measures ANOVA revealed significant group x time interaction effect for static postural stability performance (P<.001, eta(2)(p)=0.472), vertical (P<.001, eta(2)(p)=0.513), horizontal performance (P<.001, eta(2)(p)=0.467), OLS (P<.001, eta(2)(p)=0.474), BBS (P<.001, eta(2)(p)=0.440) scores, 6MWD (P<.001, eta(2)(p)=0.706), and HRQOL. Post hoc analysis revealed CWBET and CSET groups had similar improvements balance performance, exercise capacity, and HRQOL and both groups significantly improved compared with control group (P<.001). Core stabilization was significantly improved only in CSET group after 8 weeks. Conclusion: CWBET and CSET programs were equally effective and safe for improving balance performance and exercise capacity in patients with HF. (c) 2024 by the American Congress of Rehabilitation Medicine
Risk profiling of breast cancer-related lymphedema (BCRL) in patients with breast cancer via using body composition and tissue dielectric constant (TDC) method: A cross-sectional study
(Cig Media Group, Lp, 2024) Tuğral, Alper; Akyol, Murat; Colakoglu, Oyku; Bakar, Yeşim
Breast cancer-related lymphedema (BCRL) is one of the most fearsome side effects of breast cancer treatment. Higher body mass index (BMI) is a well-known risk factor for BCRL. A total of 72 patients were included. The fat mass was significantly and linearly correlated with dielectric ratios which might be indicative of preclinical Background: Breast Cancer-Related Lymphedema (BCRL) is one of the most prominent long-term side effects of breast cancer (BC) treatment. Although an increased BMI is a well-recognized risk factor for BCRL, there is a lack of knowledge regarding the potential associations between body composition and the risk of BCRL. Therefore, this study aimed to analyze the BCRL risk profiles of surgically operated BC patients via body composition and the Tissue Dielectric Constant (TDC) method, respectively. Methods: A total of 72 patients were included. Patients' risk for BCRL was assessed with Moisture MeterD (Delfin, Finland) in 4 different probes each has unique penetration depths from 0.5 (10 mm) to 5.0 (55 mm) at both upper extremities. The body composition was analyzed with Tanita-BC-420 (TANITA, Japan). Comparing the dielectric values of extremities and proportioning to one another as TDC ratio (at-risk side/unaffected side) was used to profile BCRL risk. Results: TDC values of the thorax reference point were significantly higher in all four probes on the at-risk side ( P < .05). TDC ratios in the forearm and Thorax points were significantly correlated with fat mass (r = 0.256, P = .030; r = 0.269, P = .022) as well as with visceral fat rating (VFR) (r = 0.340, P = .003; r = 0.466, P < .001). Conclusion: This study highlights the need for further care and investigation in the assessment and prediction of BCRL by considering body composition. Since the risk reduction of BCRL can be maximized by considering the individual features, we can conclude that patients with higher body fat irrespective of the BMI should be followed up regularly.
Comparative analysis of postural stability and risk of falling and developing disability among overweight and obese women over 40 years
(Elsevier, 2024) Ucurum, Sevtap Gunay; Uzunlar, Hilal; Kirmizi, Muge; Altaş, Elif Umay; Kaya, Derya Ozer
Background: Increased body mass index (BMI) adversely affects the mechanics of the musculoskeletal system. It is known that obese people have poorer postural stability and mobility -related outcomes compared to normal weight people, but there is limited research comparing overweight and class 1 obese people, two consecutive and prevalent BMI categories. Aims: To compare postural stability, functional mobility, and risk of falling and developing disability between overweight and obese women, and to investigate the relationship of BMI and body weight with the outcomes. Methods: Thirty women with class 1 obesity and 30 overweight women were included. Standing postural stability with eyes -open and eyes -closed and stability limits were assessed using the Prokin system. The Timed Up and Go Test (TUG) was used to assess functional mobility and risk of falling ( >= 11 s) and developing disability ( >= 9 s). Results: The average center of pressure displacements on the y-axis (COPY) obtained during quiet standing with both eyes -open and eyes -closed were higher in obese women than overweight women (p < 0.05) and the effect sizes were moderate for the results. The COPY values in the eyes -open and eyes -closed conditions were correlated with BMI (r = 0.295 and r = 0.285, p < 0.05). Furthermore, the COPX value in the eyes -open condition and the TUG score were correlated with body weight (r = 0.274 and r = 0.257, p < 0.05). Conclusions: Obese women had poorer static standing stability in the anteroposterior direction than overweight women, while functional mobility and risk of falling and developing disability did not differ. Furthermore, BMI and body weight were related to poorer static standing stability.
More neck pain, less spinal mobility, altered sitting posture: Sagittal spinal alignment and mobility in women with chronic neck pain
(Elsevier, 2024) Unal, Nur Efsan; Ucurum, Sevtap Gunay; Kirmizi, Muge; Altaş, Elif Umay
Background: Increasing evidence suggests that people with chronic neck pain (CNP) may display altered biomechanics beyond the cervical spine. However, whether spinal alignment and mobility are associated with neck pain is not clarified. Objectives: To investigate whether there is a significant association between neck pain intensity and sagittal spinal alignment and mobility in people with CNP, and to examine whether sagittal spinal alignment and mobility differ according to pain intensity. Design: A cross-sectional study. Method: Forty-four women with CNP were included. The neck pain intensity at rest and during neck movements was assessed with the visual analogue scale (VAS). A skin-surface measurement device was used to assess sagittal alignment and mobility while sitting and standing. Linear regression analysis was used to assess associations. Participants were divided into two groups according to the pain intensity as group with mild pain (VAS <= 4.4 cm) and group with moderate to severe pain (VAS>4.4 cm) and compared using the analysis of covariance. Results: Greater resting pain was associated with a more forward trunk during sitting (Beta = 0.433, p < 0.05). Greater pain during neck movements was associated with increased lumbar lordosis during sitting (Beta = -0.376, p < 0.05). Classified by pain intensity at rest, trunk mobility while sitting was lower and forward trunk inclination and sacral kyphosis while sitting were higher in those with moderate/severe pain (eta(2)(p) = 0.093-0.119, p < 0.05). By pain intensity during neck movements, women with moderate/severe pain exhibited lower sacral mobility while sitting (eta(2)(p) = 0.129, p < 0.05). Conclusions: Addressing the entire spine in the assessment and management of CNP may help reduce pain.
The associations of physical parameters with the closed kinetic chain upper extremity stability test, the upper quarter y balance test, and the upper limb rotation test in professional overhead athletes
(Churchill Livingstone, 2024) Kara, Firat; Gedik, Gülbin Ergin; Sahinoglu, Ertan
Objective: To investigate the associations of glenohumeral internal (IR) and external rotation (ER), horizontal adduction (HA), and thoracic spine rotation ranges of motion (ROM), isometric muscle strength of the shoulder rotators, and trunk muscle endurance with the Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST), the Upper Quarter Y Balance Test (YBT-UQ), and the Upper Limb Rotation Test (ULRT) in overhead athletes. Design: Cross-sectional study. Settings: Laboratory. Participants: One hundred twenty-one athletes were enrolled. Main outcome measures: Independent variables were: IR, ER, HA, and thoracic spine rotation ROMs, isometric muscle strength of glenohumeral IR and ER muscles, and trunk muscle endurance. Dependent variables were: CKCUEST, YBT-UQ, ULRT. Results: IR ROM of the nondominant side was associated with the CKCUEST, the YBT-UQ, and the ULRT. IR muscle strength of the dominant side was associated with the CKCUEST and the ULRT. Trunk flexor and lateral endurance of the dominant side were associated with the CKCUEST and the YBT-UQ, respectively. Conclusions: Many of the physical parameters influencing scores on the CKCUEST and the YBT-UQ are different. Common parameters influence the CKCUEST and ULRT scores, yet more parameters influence the CKCUEST score. We suggest the combined use of the CKCUEST and the YBT-UQ in overhead athletes.
Can lymphatic transport impaired by total knee arthroplasty be managed with manual lymphatic drainage?
(Mary Ann Liebert, Inc, 2024) Cihan, Emine; Yildirim, Necmiye Un; Bakar, Yeşim; Bilge, Onur
Objective: It is known that particles released from the prosthesis due to wear after joint replacement surgery affect the lymphatic system. This study aimed to investigate the effect of the manual lymphatic drainage (MLD) technique on pain, edema, and blood lactate dehydrogenase (LDH) levels in the early period of lymphatic transport affected by total knee arthroplasty (TKA). Method: Twenty-four patients who underwent TKA were randomly allocated (control: 12; MLD: 12). Both groups received postoperative rehabilitation. The MLD group also received MLD in the first 3 days after surgery. Clinical assessment was undertaken on the third day and at the sixth week postoperatively. The Visual Analog Scale (VAS) was used for pain during activity, algometer measurements for pain threshold levels, and the Frustum method for leg volumes. The LDH was recorded using laboratory measurements. Results: A significant difference was found in the VAS activity-related pain scores of the groups according to the assessment time (MLD: chi(2) = 47.175; p = 0.000; control; chi(2) = 30.995; p < 0.000). The pain threshold significantly increased in the MLD group from postoperative day 2 (2nd day, 3rd day, 6th week, respectively; p = 0.015; p = 0.001; p < 0.000). Leg volume significantly decreased over time in both groups after surgery (p < 0.001); however, there was no significant difference between the groups (first-third postoperative days and sixth week; p = 0.192; p = 0.343; p = 0.453; p = 0.908, respectively). While the LDH significantly decreased after drainage in the MLD group (first-third postoperative days; p = 0.002; p = 0.005; p = 0.006, respectively), it increased with exercise in the control group, first day (p = 0.004) and second day (p = 0.019). Conclusions: MLD added to exercise therapy is more effective than exercise therapy alone in reducing the LDH level, a marker of pain and muscle damage, but is not effective for edema due to surgery.
Does muscle oxygenation during the 6-minute walk test in fibrosing lung disease?
(European Respiratory Soc Journals Ltd, 2024) Karaahmetoglu, Fulya Senem; Pehlivan, Esra; Zeren, Melih; Ozcan, Zeynep Betul; Demirkol, Baris; Cetinkaya, Erdogan
[No abstract available]
Effects of eccentric versus concentric strengthening in patients with Subacromial pain syndrome: A randomized controlled trial
(Sage Publications Inc, 2025) Karabay, Damla; Yeşilyaprak, Sevgi Sevi; Erduran, Mehmet; Ozcan, Cem
Background: Subacromial pain syndrome (SPS) is the most common cause of shoulder pain. Therapeutic exercise is the first-line treatment for SPS; however, the ideal exercise type remains unclear. Here, we compared the effects of eccentric and concentric strengthening in patients with SPS. Hypothesis: Adding isolated eccentric strengthening to a multimodal physiotherapy program (MPP) would lead to greater improvements in outcomes compared with either MPP alone or adding isolated concentric strengthening to the MPP. Study Design: Randomized controlled trial. Level of Evidence: Level 2. Methods: A total of 45 patients were randomized to eccentric strengthening (ESG), concentric strengthening (CSG), and control (CG) groups; all groups received the MPP. The strengthening groups also performed group-specific strengthening. Shoulder pain, abduction and external rotation (ER) strength, joint position sense (JPS), the Constant-Murley Score (CMS), and the Disabilities of the Arm, Shoulder and Hand score were collected at baseline, after 12 weeks of treatment, and at week 24. Results: For CMS, ESG exhibited a greater, but not clinically meaningful, improvement than CSG and CG (P < 0.05). Eccentric abduction strength increased in ESG compared with CG. From baseline to follow-up, abduction strength increased in ESG compared with CSG and CG. Eccentric abduction strength increased in CSG compared with CG. JPS at abduction improved in the ESG compared with CG. Other between-group comparisons were not significant (P > 0.05). Conclusion: In SPS, eccentric strengthening provided added benefits, improving shoulder abduction strength and JPS at abduction, and was superior to concentric strengthening for improving shoulder abduction strength. Neither strengthening approach had an additional effect on shoulder function, pain, ER strength, or rotational JPS. Clinical Relevance: Clinicians could implement eccentric strengthening as a motor control retraining for strength and proprioception gain rather than for pain relief and reducing disability.
Does smartphone addiction impair maximal exercise capacity in young adults?
(Dokuz Eylul Univ Inst Health Sciences, 2024) Zeren, Melih; Eroğlu, Rümeysa; Şahin, Nilay Yürekdeler; Özdemir, Kadirhan; Dönmez, Batuhan; Karakum, Eshan
Purpose: Smartphone addiction may reduce the time allocated for physical activity participation. However, it is not known if there is a direct association between smartphone addiction and reduced exercise capacity. Our aim was to investigate whether smartphone addiction impairs maximal exercise capacity, as well as analyze its influence on the perceived benefits of exercise and physical activity habits in young adults. Material and Methods: Forty-six volunteers were evaluated by a symptom-limited incremental exercise test. Smartphone addiction of volunteers was evaluated using Smartphone Addiction Scale- Short Form. Physical activity participation and perceived benefits of physical activity participation were evaluated using International Physical Activity Questionnaire- Short Form and Exercise Benefits/Barriers Scale, respectively. Results: The prevalence of smartphone addiction was 65% in young adults. No significant association was detected between smartphone addiction and any of maximal exercise capacity metrics including test duration, maximum workload achieved in watts or maximum heart rate (p>0.05). Smartphone addiction did not correlate to physical activity participation either (p>0.05). Univariate linear regression revealed Exercise Benefits/Barriers Scale score was able to explain 41% of variance in exercise test duration and 37% of variance in maximal workload (p<0.01), and it was also correlated to physical activity level (r=0.424; p<0.01) Conclusion: Smartphone addiction did not directly translate into lower physical activity participation or worse exercise capacity. However, perception of the benefits of exercise had a great influence on physical activity and exercise capacity, which highlights the importance of increasing the awareness of the benefits of physical activity among young adults for maintaining physical health.
The effect of clinical exercise training on plantar pressure, the subtalar joint, and the gait cycle in pregnant women: randomized clinical trial
(MDPI, 2024) Vatansever, Ayşe Kayalı; Senisik, Seckin; Bayraktar, Dilek; Demir, Mehmet; Akercan, Fuat
Background/Objectives: This study aims to examine the effects of clinical exercise training on foot plantar pressure, the subtalar joint, and the gait cycle during pregnancy. Methods: The study was planned as a randomized, controlled, and single-blind study. Participants' demographic information, obstetric evaluation, physical activity level, fall history, and pain evaluation were recorded. Foot plantar pressure, the subtalar joint, and the gait cycle were measured through pedobarography at Gait Laboratory. The control group was recommended walking. Clinical exercise training was given to the study group 2 days a week for eight weeks. Evaluations were made on day 0 and the day corresponding to the end of week 8. Results: The study was completed with 50 people in the study group (age: 29.7 +/- 3.8 years) and 51 in the control group (age: 29.1 +/- 6.1 years). As a result of the parametric and non-parametric tests performed before and after the exercise, it was observed that there was a statistically significant difference between the two groups in weight, BMI, pain score, static plantar pressure, dynamic plantar pressure, subtalar joint flexibility, duration of the walking period, and multistep walking speed (p < 0.01). The two groups had a significant difference only in the dominant midfoot plantar pressure (p > 0.05). Conclusions: According to our research, weight control and pain relief are observed in women who engage in clinical exercise in the second trimester of pregnancy; plantar pressure and subtalar joint flexibility are preserved, the walking period does not increase, and the multistep walking speed can be maintained after eight weeks.
Investigation of respiratory muscle strength and its influence on exercise capacity and quality of life in patients with idiopathic pulmonary fibrosis
(Mattioli 1885, 2024) Pehlivan, Esra; Zeren, Melih; Niksarlioglu, Elif Yelda; Karaahmetoglu, Fulya Senem; Ozcan, Zeynep Betul; Balci, Arif; Demirkol, Baris
Background: Adequate respiratory muscle strength is required to meet the increased ventilatory demand during physical activities. However, it is not well known whether respiratory muscle strength is impaired in patients with idiopathic pulmonary fibrosis (IPF). Objectives: This study aimed to investigate the relationship between respiratory muscle strength and exercise capacity, quality of life, physical activity level, and fatigue in IPF patients. Methods: The study comprised 30 individuals with idiopathic pulmonary fibrosis (IPF) and 30 healthy controls. Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) were measured to assess respiratory muscle strength. The International Physical Activity Questionnaire-Short Form, 6-minute walk test distance (6MWD), St George Respiratory Questionnaire (SGRQ), and Fatigue Severity Scale (FSS) were employed to evaluate physical activity level, exercise capacity, quality of life, and fatigue severity, respectively. Results: MIP (81 +/- 29 vs.73 +/- 20 cmH(2)O) and MEP (93 +/- 31 vs. 93 +/- 34 cmH(2)O) did not differ significantly between IPF patients and controls (p>0.05). In patients with IPF, MIP was significantly correlated with 6MWD (r=0.533), SGRQ (r=-0.428), and FSS (r=-0.433). Multivariate models including MIP, MEP, FEV1, FVC, and PA level explained 74% of the variance in the 6MWD (p<0.001), and MIP, FEV1, and PA level were independent predictors of the 6MWD, with FEV1 being the strongest predictor (beta=0.659). Multivariate models predicting SGRQ revealed none of MIP, FEV1 or PA level was directly influencing the SGRQ score. Conclusions: This study suggests that patients with IPF do not have respiratory muscle weakness. Inspiratory muscle strength has a direct influence on exercise capacity but an indirect effect on quality of life, probably by influencing exercise capacity.
Levels of oxidative stress, selenium and zinc, and health-related quality of life in healthy males before and after COVID-19 vaccination
(Dustri-Verlag Dr Karl Feistle, 2024) Özdemir, Kadirhan; Saruhan, Ercan; Benli, Tuba Kaya; Kaya, Gozde; Cil, Zafer; Yavuz, Melike Yuksel; Meral, Orhan; Kavak, Servet
Objective: The aim of this study was to determine the changes in oxidative stress, selenium (Se) and zinc (Zn), and health-related quality of life (HRQoL) following COVID-19 vaccination. Materials and methods: 20 healthy male subjects received 2 doses of inactivated COVID-19 vaccines between January and August 2021. Peripheral blood samples were taken immediately before the 1 st dose and 3 days after the 2 nd dose of the vaccine. The oxidant status (malondialdehyde (MDA) and total oxidant status (TOS)), antioxidant status (superoxide dismutase (SOD) and total antioxidant status (TAS)), Se and Zn, and HRQoL levels of the subjects were evaluated. In addition, oxidative stress index (OSI) was calculated. Results: The mean age and body mass index of the subjects were 45.85 +/- 6.38 years and 28.53 +/- 4.50 kg/m(2), respectively. Following COVID-19 vaccinations, TAS levels decreased (p = 0.004); however, SOD levels increased (p = 0.012) significantly. In addition, there were no significant changes in TOS and MDA levels (p > 0.05). Moreover, OSI showed no significant differences (p > 0.05). After the vaccination process, Se and Zn increased; however, the differences were insignificant (p > 0.05). In addition, the HRQoL of the subjects did not change (p > 0.05). Conclusion: Although the antioxidant status decreased after 2 doses of COVID-19 vaccination, the oxidant status and the oxidative stress levels of the subjects remained stable. Thus, 2 doses of inactivated COVID-19 vaccination may have no effects on oxidative stress levels in healthy males. In addition, there were no changes in the serum concentrations of Se and Zn. Moreover, there was no difference in the HRQoL of the subjects. Therefore, COVID-19 vaccination process may not affect serum Se and Zn levels and HRQoL in healthy males.
Sleep quality and its predictors among dyspnea, fatigue and exercise capacity in pulmonary arterial hypertension
(Taiwan Soc Cardiology, 2024) Ceylan, Raziye; Demir, Rengin; Zeren, Melih; Sinan, Umit Yasar; Kucukoglu, Mehmet Serdar
Background: Poor sleep quality is an overlooked symptom in patients with pulmonary arterial hypertension (PAH), however it may significantly contribute to disease burden. Objectives: The aim of this study was to assess the sleep quality of patients with PAH and investigate its association with dyspnea, fatigue, and exercise capacity. Methods: Forty-five patients were included. Sleep quality of the patients was assessed by the Pittsburgh Sleep Quality Index (PSQI), dyspnea levels were assessed by the UCSD-Shortness of Breath Questionnaire (UCSD-SOBQ), Baseline Dyspnea Index (BDI), Modified Medical Research Council (MMRC) dyspnea scale and Modified Borg Dyspnea scale, fatigue levels were evaluated with the Fatigue Severity Scale and Borg Rating of Perceived Exertion, and functional exercise capacity was evaluated with the 6-minute walk test (6MWT). Results: Among the patients with PAH, 64% had poor sleep quality (PSQI > 5). PSQI score was significantly correlated with MMRC scale (r = -0.561), UCSD-SOBQ (r = 0.497), BDI (r = -0.468), and 6MWT (r = -0.412) (p < 0.05). There was no significant relationship between sleep quality and fatigue. A regression model including MMRC and 6MWT could explain 32% of variance in PSQI (p < 0.05), and MMRC score was an independent predictor for PSQI (p < 0.05). In addition, MMRC score had a greater influence on PSQI than 6MWT ((3 = 0.548 vs. 0.019). Conclusions: Poor sleep quality is common in patients with PAH and is associated with poor exercise capacity and dyspnea. Patients with severe dyspnea are particularly at higher risk of poor sleep quality. Consideration of sleeprelated complaints and underlying mechanisms when planning symptomatic treatments for these patients may help provide better management for PAH.
Takım sporcularının yaşam becerisinin sportif sorunlarla başa çıkma sürecine etkisinin incelenmesi: Kesitsel bir çalışma
(2023) Uzunlar, Hilal; Kaya, Derya Özer; Korucu, Tuğçe Şirin; Seçer, Erhan; Dinç, Güldane
Amaç: Sporda sorunlarla karşılabilmekte ve bu sorunlarla başa çıkma süreci yaşam becerisinden etkilenebilmektedir. Bu do ğrultuda takım sporcularının yaşam becerilerinin, sportif sorunlarla başa çıkma sürecine etkisinin incelenmesi amaçlandı. Gereç ve Yöntemler: Ça- lışmaya, aktif takım sporu yapan 95 k işi [69 (%72,6) erkek, medyan yaş 23 yıl] dâhil edildi. Katılımcıların sosyodemografik özellikleri, fi- ziksel aktivite düzeyleri (Cooper Anketi), yaşam becerileri (Sporun Yaşam Becer ilerine Etk isi Ölçeği) ve sorunlarla ba şa ç ıkma sürec i (Sportif Sorunlarla Ba şa Çıkma Becerileri Envanteri-26) oluşturulan formlar ile çevrim içi olarak değerlendirildi. Bulgular: Çalışmadaki erkek katılımcıların sorunlarla başa çıkma süreci kadınlardan daha yük- sekti (p=0,044). Genel iyilik hâli çok iyi olanların (p<0,001), fiziksel aktivite düzeyi yüksek olanların (p=0,020), spora yönel ik yaralanma geçirmemiş olanların (p=0,029) yaşam becerisinin yüksek olduğu sap- tandı. Yaşam becerisi ve sorunlarla başa çıkma süreci spor branşı, eği- tim durumu, beden kitle indeksine göre değişiklik göstermedi (p>0,05). Ayrıca başa çıkma süreci ile spor yaşı (r=0,243), lisans süresi (r=0,290), haftalık antrenman sayısı (r=0,220) zayıf düzeyde ilişkiliyken, yaşam becerisi ise sadece haftalık antrenman sayısı ile (r=0,251) zayıf ilişkili bulundu. Sonuç: Takım sporcularının genel iyilik hâli, fiziksel aktivite düzeyi, yaralanmalara karşı korunmasının yaşam becerilerini iyileştir- mede önemli olduğunu, takım spor bran şı ve ilişkili faktörlerden ba- ğımsız olarak yaşam becerilerinin artırılmasının sorunlarla başa çıkma sürecini olumlu yönde değiştirebileceğini düşünmekteyiz.
Understanding changes in pulmonary function and functional status in breast cancer patients after systemic chemotherapy and radiotherapy: a prospective study
(Bmc, 2024) Tuğral, Alper; Aribas, Zeynep; Akyol, Murat; Bakar, Yeşim
BackgroundRespiratory complications in breast cancer (BC) patients after chemotherapy (CT) and radiotherapy (RT) have been well acquainted and these complications should be investigated to prevent secondary problems and/or improve BC patients' clinical outcomes. Therefore, this study aimed to assess the potential acute effect of systemic chemotherapy and radiotherapy on respiratory function and functional status of patients with breast cancer.MethodsA total of 25 BC patients who were candidates for systemic chemotherapy and radiotherapy were recruited after oncological examination and included in this study. Respiratory function and functional status were assessed with the Pulmonary Function Test (PFT) and the Six-Minute Walk Test (6MWT), respectively. Patients were assessed before CT (c0), after CT (c1), and after RT (r1).Results25 BC patients were assessed in c0 and c1 while only 15 out of 25 patients (60%) were assessed in r1. The actual values of Forced vital capacity (FVC) (t = 2.338, p =.028), Forced expiratory volume in 1s (FEV1 (t = 2.708, p =.012), and the forced expiratory flow of between 25% and 75% of vital capacity (FEF25-75%) (t = 2.200, p =.038) were found significantly different after systemic CT. Inspiratory (MIP) and expiratory (MEP) muscle strength also did not show a significant change from c0 to c1. A significant effect of the type of surgery was found (Wilks' lambda, F [1, 19] = 6.561, p =.019, eta p2 = 0.25) between c0 and c1 in actual FVC value. The main effect of time was found significant in FVC (F [2, 28] = 4.840, p =.016, eta p2 = 0.25) from c0 to r1. Pairwise comparisons with Bonferroni correction showed that there was a significant difference between c0 and r1 (p =.037).DiscussionThe present study showed decreased FVC and FEV1 actual values and percent predicted rates from baseline to the completion of treatment. Since the interactional effect of the type of surgery was significant, we suggest that clinical and demographic factors such as age should be considered when interpreting the early changes in PFT. In addition, the significant linear trend of decreasing in some specific outcomes in respiratory function also highlighted the need for continuous monitoring of potential respiratory problems in patients with BC from baseline to the completion of chemotherapy and radiotherapy.
Two-particle azimuthal correlations in ?p interactions using pPb collisions at ?sNN=8.16 TeV
(Elsevier, 2023) Tumasyan, A.; Adam, W.; Bergauer, T.; Dragicevic, M.; Del Valle, A. Escalante; Fruehwirth, R.; The ATLAS collaboration; Özdemir, Kadirhan
The first measurements of the Fourier coefficients (V-n Delta) of the azimuthal distributions of charged hadrons emitted from photon-proton (gamma p) interactions are presented. The data are extracted from 68.8nb(-1) of ultra-peripheral proton-lead (pPb) collisions at root s(NN)= 8.16 TeV using the CMS detector. The high energy lead ions produce a flux of photons that can interact with the oncoming proton. This gamma p system provides a set of unique initial conditions with multiplicity lower than in photon-lead collisions but comparable to recent electron-positron and electron-proton data. The V-n Delta coefficients are presented in ranges of event multiplicity and transverse momentum (p(T)) and are compared to corresponding hadronic minimum bias pPb results. For a given multiplicity range, the mean p(T) of charged particles is smaller in gamma p than in pPb collisions. For both the gamma p and pPb samples, V-1 Delta is negative, V-2 Delta is positive, and V-3 Delta consistent with 0. For each multiplicity and p(T) range, V-2 Delta is larger for gamma p events. The gamma p data are consistent with model predictions that have no collective effects. (c) 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP(3).
Assessment of the cardiorespiratory fitness and the quality of life of patients with breast cancer undergoing chemotherapy: a prospective study
(Springer Japan Kk, 2023) Akyol, Murat; Tuğral, Alper; Aribaş, Zeynep; Bakar, Yeşim
BackgroundDiminished cardiorespiratory fitness is a well-known side effect of chemotherapy as well as a risk factor for potential cardiovascular diseases among cancer patients. This study aimed to assess the potential effects of systemic adjuvant (ACT) or neoadjuvant (NACT) chemotherapy on cardiorespiratory fitness and quality of life (QoL) among breast cancer (BC) patients.MethodsDemographic data, cardiorespiratory fitness, health-related QoL domains were assessed with simple data form, six-minute walk test (6MWT), European Organization for Research and Treatment of Cancer quality of life module (EORTC-C30), and Functional Assessment of Cancer Therapy (FACT-B+), respectively. Time1 (T1, prior to chemotherapy), Time2 (T2; interim assessment), and Time3 (T3, final assessment) were set as assessment points.ResultsA total of 42 patients (32 ACT vs 10 ACT) completed all assessments. There were no significant differences of main effect of time and time*group interaction on total walked distance (TWD) after controlling for age and BMI (F(2,28) = 1.309, p = 0.286; F(2,28) = 1.444, p = 0.253). EORTC symptoms subscale was found to be correlated with EORTC and FACT-B+ physical function (PF) subscales (r = - 861, p < 0.001; r = - 0.877, p < 0.001) in T3. The EORTC PF subscale was found to be correlated with the TWD in the baseline (r = 0.411, p = 0.024).ConclusionsThis study showed that the effect of chemotherapy on diminished PF and remarkably increased symptom burden among BC patients. Yet, the type of chemotherapy had no effect on TWD regarding cardiorespiratory fitness. Monitoring potential functional decline regarding cardiorespiratory fitness can be performed via simple field tests such as 6MWT.

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