Quality of life and somatic physical function of patients with colorectal cancer who underwent oxaliplatin-based systemic chemotherapy: a prospective study

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dc.authoridkebabci, eyup/0000-0001-8900-2325
dc.authoridBakar, Yesim/0000-0002-5603-2891
dc.contributor.authorTugral, Alper
dc.contributor.authorKebabci, Eyup
dc.contributor.authorAribas, Zeynep
dc.contributor.authorAkyol, Murat
dc.contributor.authorCan, Aysegul
dc.contributor.authorBakar, Yesim
dc.date.accessioned2025-03-20T09:51:20Z
dc.date.available2025-03-20T09:51:20Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractintroductionThis study aimed to study the potential effects of oxaliplatin-based chemotherapy on cardiorespiratory fitness, handgrip strength (HGS), body composition, and quality of life (QoL) of stages III-IV colorectal cancer (CRC) patients before the first cycle (T0) and after the last cycle of systemic adjuvant/neoadjuvant chemotherapy (T1).MethodsCardiorespiratory fitness, HGS, body composition, and QoL were evaluated with the six-minute walk test (6MWT), hydraulic hand dynamometer, body composition analyzer, and Functional Assessment of Cancer Therapy-Colon (FACT-C) questionnaire in both T0 and T1, respectively.ResultsTwenty-eight CRC patients were included in this study. The total walked distance (TWD) was found to be decreased from T0 to T1 (499.72 m vs. 488.56 m); however, this change was not significant (z = -.706, p = 0.48). Type of chemotherapy whether adjuvant or neoadjuvant also showed no significant effect on TWD (z = -.1.372, p = .17 vs z = -1.180, p = .238, respectively). The QoL was significantly decreased (T0 = 118.35 vs T1 = 110.77, t = 2.176,p = 0.05). The TWD was significantly correlated with the physical well-being (PWB) subscale of FACT-C (r = .64, p = 0.001) as well as with HGS (r = .46, p = .018) in T0. After controlling for age, type of chemotherapy, and type of regimen, the HGS did not show a significant difference from T0 to T1 (F(1,23) = 1.557, p = .22, eta p2 = .06). However, the effect of time x gender showed significant difference from T0 to T1 (F(1,23) = 4.906, p = .037, eta p2 = .17).ConclusionThis study showed the decreased QoL and physical well-being of CRC patients who underwent oxaliplatin-based treatment. In addition, the gender effect of decreased HGS should be considered further when planning an oncological rehabilitation program.
dc.identifier.doi10.1007/s00520-024-08937-x
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.issue11
dc.identifier.pmid39422842
dc.identifier.scopus2-s2.0-85206813804
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00520-024-08937-x
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2494
dc.identifier.volume32
dc.identifier.wosWOS:001335624500002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofSupportive Care in Cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectColorectal cancer
dc.subjectChemotherapy
dc.subjectSix-minute walk test
dc.subjectCardiorespiratory fitness
dc.titleQuality of life and somatic physical function of patients with colorectal cancer who underwent oxaliplatin-based systemic chemotherapy: a prospective study
dc.typeArticle

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