Quality of life and somatic physical function of patients with colorectal cancer who underwent oxaliplatin-based systemic chemotherapy: a prospective study
dc.authorid | kebabci, eyup/0000-0001-8900-2325 | |
dc.authorid | Bakar, Yesim/0000-0002-5603-2891 | |
dc.contributor.author | Tugral, Alper | |
dc.contributor.author | Kebabci, Eyup | |
dc.contributor.author | Aribas, Zeynep | |
dc.contributor.author | Akyol, Murat | |
dc.contributor.author | Can, Aysegul | |
dc.contributor.author | Bakar, Yesim | |
dc.date.accessioned | 2025-03-20T09:51:20Z | |
dc.date.available | 2025-03-20T09:51:20Z | |
dc.date.issued | 2024 | |
dc.department | İzmir Bakırçay Üniversitesi | |
dc.description.abstract | introductionThis study aimed to study the potential effects of oxaliplatin-based chemotherapy on cardiorespiratory fitness, handgrip strength (HGS), body composition, and quality of life (QoL) of stages III-IV colorectal cancer (CRC) patients before the first cycle (T0) and after the last cycle of systemic adjuvant/neoadjuvant chemotherapy (T1).MethodsCardiorespiratory fitness, HGS, body composition, and QoL were evaluated with the six-minute walk test (6MWT), hydraulic hand dynamometer, body composition analyzer, and Functional Assessment of Cancer Therapy-Colon (FACT-C) questionnaire in both T0 and T1, respectively.ResultsTwenty-eight CRC patients were included in this study. The total walked distance (TWD) was found to be decreased from T0 to T1 (499.72 m vs. 488.56 m); however, this change was not significant (z = -.706, p = 0.48). Type of chemotherapy whether adjuvant or neoadjuvant also showed no significant effect on TWD (z = -.1.372, p = .17 vs z = -1.180, p = .238, respectively). The QoL was significantly decreased (T0 = 118.35 vs T1 = 110.77, t = 2.176,p = 0.05). The TWD was significantly correlated with the physical well-being (PWB) subscale of FACT-C (r = .64, p = 0.001) as well as with HGS (r = .46, p = .018) in T0. After controlling for age, type of chemotherapy, and type of regimen, the HGS did not show a significant difference from T0 to T1 (F(1,23) = 1.557, p = .22, eta p2 = .06). However, the effect of time x gender showed significant difference from T0 to T1 (F(1,23) = 4.906, p = .037, eta p2 = .17).ConclusionThis study showed the decreased QoL and physical well-being of CRC patients who underwent oxaliplatin-based treatment. In addition, the gender effect of decreased HGS should be considered further when planning an oncological rehabilitation program. | |
dc.identifier.doi | 10.1007/s00520-024-08937-x | |
dc.identifier.issn | 0941-4355 | |
dc.identifier.issn | 1433-7339 | |
dc.identifier.issue | 11 | |
dc.identifier.pmid | 39422842 | |
dc.identifier.scopus | 2-s2.0-85206813804 | |
dc.identifier.scopusquality | Q1 | |
dc.identifier.uri | https://doi.org/10.1007/s00520-024-08937-x | |
dc.identifier.uri | https://hdl.handle.net/20.500.14034/2494 | |
dc.identifier.volume | 32 | |
dc.identifier.wos | WOS:001335624500002 | |
dc.identifier.wosquality | Q1 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | |
dc.publisher | Springer | |
dc.relation.ispartof | Supportive Care in Cancer | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.snmz | KA_WOS_20250319 | |
dc.subject | Colorectal cancer | |
dc.subject | Chemotherapy | |
dc.subject | Six-minute walk test | |
dc.subject | Cardiorespiratory fitness | |
dc.title | Quality of life and somatic physical function of patients with colorectal cancer who underwent oxaliplatin-based systemic chemotherapy: a prospective study | |
dc.type | Article |