Effect of intraperitoneal and systemic sirolimus administration on postoperative peritoneal adhesions in rats

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dc.contributor.authorİnal, Abdullah
dc.contributor.authorSaydam, Serdar
dc.date.accessioned2022-02-15T16:57:51Z
dc.date.available2022-02-15T16:57:51Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractPurpose: Low incidence of surgery-induced peritoneal adhesions in posttransplant patients is a wellknown subject. The aim of this study was to investigate the role sirolimus to prevent intra-abdominal adhesions and compare the systemic and intraperitoneal efficacy of the intervention. Methods: A total of 21 male rats randomly constituted three groups as intraperitoneal 0.015mg/kg sirolimus administered group, 0.1 mg/kg oral sirolimus administered group, and control group. A surgical peritoneal adhesion model was performed. All rats were euthanized on postoperative 7. day for macroscopic adhesion evaluation and histopathologic examination. Results: Intraperitoneal sirolimus administration significantly reduced adhesion formation. On the other hand, one-dose systemic administration did not show significant difference compared with control group. Conclusions: Intraperitoneal sirolimus administration at therapeutic doses significantly reduces postoperative intraabdominal adhesions in rat model.en_US
dc.identifier.doi10.30621/jbachs.977476
dc.identifier.endpage200en_US
dc.identifier.issn2458-8938
dc.identifier.issn2564-7288
dc.identifier.issue3en_US
dc.identifier.startpage195en_US
dc.identifier.trdizinid505619
dc.identifier.urihttps://doi.org/10.30621/jbachs.977476
dc.identifier.urihttps://hdl.handle.net/20.500.14034/292
dc.identifier.volume5en_US
dc.identifier.wosWOS:000713673500025en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDokuz Eylul Univ Inst Health Sciencesen_US
dc.relation.journalJournal Of Basic And Clinical Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSurgery-Induced Tissue Adhesionsen_US
dc.subjectSirolimusen_US
dc.subjectSurgical Adhesionsen_US
dc.subjectPostsurgical Adhesionsen_US
dc.subjectAbdominal Adhesionsen_US
dc.subjectPreventionen_US
dc.subjectAntibodiesen_US
dc.subjectInterleukin-6en_US
dc.subjectReductionen_US
dc.subjectRapamycinen_US
dc.subjectTherapyen_US
dc.subjectModelen_US
dc.titleEffect of intraperitoneal and systemic sirolimus administration on postoperative peritoneal adhesions in ratsen_US
dc.typeArticleen_US

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