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Öğe Effect of latanoprost on choroidal thickness in patients with newly diagnosed primary open-angle glaucoma(Kare Publ, 2024) Buyukmurat, Neslihan; Karadag, Erdi; Ozbek, HanefiOBJECTIVE: The purpose of this study was to assess the influence of latanoprost on choroidal thickness in patients with newly diagnosed primary open-angle glaucoma using Swept-Source Optical Coherence Tomography (SS-OCT). METHODS: The retrospective, non-randomized study comprised 40 newly diagnosed primary open-angle glaucoma patients receiving latanoprost therapy (Group 1). Additionally, 40 age- and sex-matched healthy subjects served as the control group (Group 2). Using SS-OCT, measurements of subfoveal, horizontal temporal, and horizontal nasal quadrants choroidal thickness, as well as intraocular pressure (IOP) and retinal nerve fiber layer (RNFL) thickness values, were collected at baseline and after 1 month for both groups. RESULTS: The mean age was 39.8 +/- 4.15 years (range: 18-45 years) in group 1 and 41.67 +/- 7.95 years (range: 18-45 years) in group 2 (p>0.05). The mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant prior to latanoprost therapy were 263.57 +/- 84.23 mu m, 233.05 +/- 80.08 mu m, and 219.52 +/- 83.28 mu m in the group 1 whereas 278.9 +/- 93.88 mu m, 243.8 +/- 73.37 mu m and 209.85 +/- 92.92 mu m in the group 2. After latanoprost therapy, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant changed significantly to 299.77 +/- 41.29 mu m, 269.9 +/- 43.80 mu m, and 261.32 +/- 45.60 mu m in the group 1 (p=0.02, p=0.016, and p=0.012, respectively) (Table 1). However, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant and horizontal nasal quadrant in group 2 changed not significant and was 279.25 +/- 103.37 mu m, 246.42 +/- 87.07 mu m and 203.62 +/- 106.74 mu m, respectively (p=0.4, p=0.5 and p=0.9, respectively). The mean IOP decreased significantly in group 1 (p=0.000) but did not change significantly in group 2 (p=0.153). There was no difference in RNFL thickness values at baseline and 1 st month in group 1 and group 2 (p>0.05). CONCLUSION: Topical latanoprost may increase choroidal thickness. Swept Source-OCT may contribute to our understanding of the actions of latanoprost on choroidal thickness.Öğe Comparison of the effects of recombinant human epidermal growth factor (rhEGF) and alendronate sodium on tibial fracture healing in rats: an experimental study(Cukurova Univ, Fac Medicine, 2024) Tepedelenlioglu, Huseyin Emre; Abduelaliyev, Ferid; Ahmadov, Asim; Dizakar, Saadet Ozen Akarca; Ozogul, Candan; Esen, ErdincPurpose:The objective of this study is to compare the effects of recombinant human epidermal growth factor (rhEGF) on bone healing with those of alendronate, a bisphosphonate widely used in practice.Materials and Methods:An iatrogenic fracture was created in the tibial shaft of 24 Sprague-Dawley rats with osteotome and fixed with an intramedullary Kirschner wire (K-wire). After surgery, Group 1 was given 0.2 mg/kg/day of oral alendronate sodium on postoperative Day 1 to 28, Group 2 received a single dose of 0.5 mg/kg of intraosseous rhEGF on postoperative Days 1 and 14, and Group 3 was followed for a total of four weeks with oral saline. At the end of Week 4, the animals were euthanized and the lower extremities were removed by stripping the soft tissues without damaging the callus. Tissue samples of groups were prepared and and stained with hematoxylin-eosin. After staining, histological scoring was performed to evaluate the degree of union.Results: Alendronate sodium group demonstrated a mean histological score of 6.95 +/- 1.28. The rhEGF group had a lower mean score of 4.85 +/- 1.66. The placebo group exhibited the least progress in bone healing with a mean score of 4.10 +/- 1.68. The histological score was significantly higher in the alendronate sodium group compared to both the rhEGF and placebo groups. There was also a statistically significant difference between the rhEGF and placebo groups in terms of scores. Conclusion: Alendronate sodium enhanced fracture healing processes in rats. The role of rhEGF in bone healing requires further exploration. As the understanding of bisphosphonates and growth factors in bone healing evolves, the strategies for optimizing patient care in orthopedic settings are expected to be developed.Öğe Evaluation of palmar creases of healthy young individuals of different countries(Cukurova Univ, Fac Medicine, 2024) Sahin, Necati Emre; Bakici, Rukiye Sumeyye; Oner, Zulal; Toy, SeymaPurpose: This study aims to evaluate the potential effects of gender and country factors on palmar creases by examining the palmar creases of young adults from various countries. Materials and Methods: The study involved a total of 220 volunteers, including 120 males and 100 females aged 18-30, from seven different countries (Jordan, Sudan, Somalia, Iran, Iraq, Tanzania and Turkey), as well as students from Karabuk University. Hand types were evaluated based on palmar creases and the number of origins for both hands. Total Degree of Transversality (TDoT) values for palmar creases were calculated. Classification of palmar creases and comparison of T -DoT values for both hands were performed between genders and countries. Results: The study analyzed 440 hands from 220 individuals, identifying 1 Simian, 8 Suwon, and 5 Sydneytype hands, while categorizing the remaining 426 hands as normal type. Regarding the number of palmar crease origins, it was observed that there was a single origin in 3 hands, two origins in 309 hands and three origins in 119 hands. Significant associations were found between genders and countries in the number of palmar crease origins. In addition, significant differences in right hand TDoT values were found between genders and countries. Conclusion: In spite of limitations in sample selection and size, these results are important in providing a basis for future in-depth research on palmar creases at later stages, although generalizability to the specific countries represented in the sample may be limited. Consequently, this study highlights variations among countries concerning both the number of palm crease origins and right-hand T -DoT values.Öğe Gender prediction using geometric morphometry with parameters of the cranium obtained from computed tomography images(Cukurova Univ, Fac Medicine, 2024) Secgin, Yusuf; Oner, Zulal; Oner, Serkan; Toy, SeymaPurpose:The gender difference of the cranium skeleton is of great importance in forensic anthropology and forensic medicine sciences. This study is based on this hypothesis and the gender prediction rate was obtained by processing cranium images obtained from computed tomography (CT) using geometric morphometry.Materials and Methods:CT images of 200 individuals between the ages of 25 and 65 were used in our study. The images were opened at the personal workstation Horos Medical Image Viewer (Version 3.0, USA) program and processed with 3D Curved Multiplanar Reconstruction (MPR). The line passing through the nasion and inion points of the images obtained as a result of the process was determined, and all images were brought to the orthogonal plane. Later, the images were overlapped and saved in JPEG format with 100% magnification. JPEG images saved were converted into TPS format, and 21 homologous landmarks were placed. Generalized Procrustes Analysis (GPA) and Principal Component Analysis (PCA) were applied to thecoordinates of landmarks, and shape variations and dimensionality were corrected by gathering the images to the center of gravity. Next, Linear Discriminant Analysis (LDA) was applied to the coordinates, the dimensionality of which was corrected. Results:The study found that 74.465% of the coordinates of 21 homologous landmarks gathered to the center of gravity could be explained with the first three PCs. As a result of the LDA applied to these coordinates, a gender prediction rate of 86.5% was obtained.In addition, a slight difference was found between the GPA sum of squares and the tangent sum of squares (0.57). Conclusion:The images of the cranium obtained from CT showed a high dimorphism by geometric morphometry analysisÖğe Deep Learning-based Classification of Breast Tumors using Raw Microwave Imaging Data(Gazi Univ, 2024) Bicer, Mustafa Berkan; Eliiyi, Ugur; Tursel Eliiyi, DenizBreast cancer is the leading type of malignant neoplasm disease among women worldwide. Breast screening makes extensive use of powerful techniques such as x-ray mammography, magnetic resonance imaging, and ultrasonography. While these technologies have numerous benefits, certain drawbacks such as the use of low-energy ionizing x-rays, a lack of specificity for malignant tissues, and cost, have motivated researchers to investigate novel imaging and detection modalities. Microwave imaging (MWI) has been extensively studied due to its low-cost structure and ability to perform measurements using non-ionizing electromagnetic waves. This study proposes a novel convolutional neural network (CNN) model for detecting and classifying tumor scatterers in MWI simulation data. To accomplish this, 10001 different numerical breast models with tumor scatterers of varying numbers and positions were developed, and the simulation results were derived using the synthetic aperture radar (SAR) technique. The presented CNN structure was trained using 8000 pieces of simulation data, and the remaining data were used for testing, achieving accuracy rates of 99.61% and 99.75%, respectively. The proposed model is compared to three state-of-the-art models on the same dataset in terms of classification performance. The results demonstrate that the proposed model effectively performs effectively well in detecting and classifying tumor scatterers.Öğe Self-Report Methods for Assessing Emotions: Understanding Structure and Accuracy of Measurement(Istanbul Univ, Fac Letters, Dept Psychology, 2023) Caliskan, Onur; Kapucu, AycanEmotion is structurally multifaceted with different components. One of these components, subjective experience, is pivotal in defining and measuring emotions. Self-report methods are used to ascertain the subjective experience of emotion. Unlike the neural and behavioral components of emotion, the qualities in subjective experience have been analyzed relatively less. However, for a more accurate and valid determination, the relevant structure should be well conceptualized. In this sense, the first part of this review precisely refers to the concept of emotional experience. This section concerns the distinctive meaning of subjective experience and details the correlation of subjective experience with other components of emotion. Next, the methods of accessing and expressing this experience will be discussed. Finally, the various scales in literature for measuring subjective experience are discussed. The status of these scales in Turkish and international literature is summarized. After conceptualizing subjective experience, the second part includes crucial aspects that may be useful for a more accurate and valid measurement. For this purpose, temporal issues that are important in measurement are addressed. First, the results of the temporal position of measurement, which may be in the past, future, or online; the results of the differences in the temporal emphasis in the instruction and the mechanism by which it affects the determination are mentioned. Subsequently, systematic explanations of individual differences in the experience of emotion are emphasized. Emotional granularity, referring to the extent to which an emotion is expressed in detail, and emotional dialecticism, indicating the state of experiencing different emotions together, are explained. Individual differences and their potential contribution to measuring and understanding emotion were addressed. The different views on the subjective experience of emotion, the temporal aspects, individual differences that can matter for measurement, and the mechanisms by which they can contribute to determination practices were discussed. Keywords: Measuring emotion, self-report, subjective experience of emotion, emotional experience, phenomenology of emotion.Öğe Morphotectonic Development ofDolines on Mt. Bozdag (Karaburun Peninsula)(Tmmob Jeoloji Muhendisleri Odasi, 2024) Sener, Mehmet FurkanThis study investigated the morphometric and morphogenetic characteristics of dolines in the Bozda & gbreve; Massif, located in the north of Karaburun Peninsula. Dissolution dolines are one of the characteristic surface features of mid-latitude high karst plateaus, and doline morphometry is one of the methods commonly used to study the morphotectonic evolution characteristics of karst plateaus. In this study, an automatic extraction technique was used with a high-resolution digital elevation model to determine the areal distribution, density and morphometric characteristics of dolines. After the dolines were identified, several morphometric parameters such as area, perimeter, circularity index, length, width and elongation rates were calculated. According to the analyses and results obtained, a total of 564 dolines were detected in the area, with a maximum density of 74 dolines/km 2 . All the dolines, with an average elevation of 1,080 metres, are located on limestone from the Camibo & gbreve;az & imath; Formation. The dolines extend in roughly NW-SE direction, parallel to lineaments in the area, which formed in relation to tectonic processes that started with palaeotectonic evolution and influenced the Karaburun platform in the Izmir-Ankara zone during the Cretaceous period.Öğe Semantic and Structural Analysis of MIMIC-CXR radiography reports with NLP Methods(Gazi Univ, 2024) Uslu, Ege Erberk; Sezer, Emine; Gueven, Zekeriya AnilArtificial intelligence that aims to imitate human decision-making processes, using human knowledge as a foundation, is a critical research area with various practical applications in different disciplines. In the health domain, machine learning and image processing techniques are increasingly being used to assist in diagnosing diseases. Many healthcare reports, such as epicrisis summaries prepared by clinical experts, contain crucial and valuable information. In addition to information extraction from healthcare reports, applications such as automatic healthcare report generation are among the natural language processing research areas based on this knowledge and experience. The primary goals are to reduce the workload of clinical experts, minimize the likelihood of errors, and save time to speed up the diagnosis process. The MIMIC-CXR dataset is a huge dataset consisting of chest radiographs and reports prepared by radiology experts related to these images. Before developing a natural language processingbased model, preprocessing steps were applied to the dataset, and the results of syntactic and semantic analyses performed on unstructured report datasets are presented. The results show that most examined words and phrases exhibit minimal semantic inference disparities. The generic named entity recognition method demonstrates comparatively lower effectiveness than the ngram technique in extracting word frequencies. However, named entity recognition facilitated the identification of medical entities within the dataset. This study is expected to provide insights for developing language models, particularly for developing a natural language processing model on the MIMIC-CXR dataset.Öğe Occupation Period of Menemen (1919-1922): A Review Supported by Geographical Information(E.U. Printing And Publishing House, 2024) Tepealti, Fahrettin; Asik, Suleyman; Karakaya, EmreThe 7th article of the Armistice of Mudros which has been signed due to Ottoman Empires lose World War I, gave Entente Powers the right of occupation of Ottoman territory. Greece, owing to that article, landed its army in Izmir on May 15, 1919, and started a brutal occupation. Menemen, a district of Izmir, exposed to that brutal, gory occupy on 22nd May. During the occupation of Menemen, Turkish-Muslim folk witnessed numerous grievous events and attacked by both Greek army and their local collaborators. Undoubtedly, the bloodiest one, called Bloody Tuesday on the other words Menemen Katliam & imath; (Massacre of Menemen), happened on June 17, 1919. This kind of savagery events has been occurring more than twelve hundred days throughout occupy. Because of their defeat of the Turkish War of Independence, the Greek army, escape and left Izmir completely as of September 9th. With the introduction of digital technologies into all areas of life, like the other branches of social sciences, historiography was undoubtedly affected by this process and took new research methodologies to the field. Geographic Information Systems (GIS) stand out as a prominent digital technological method. Realizing the potential of GIS, some historians have started to use these systems in historical researches. As a result, Historical GIS, a rapidly developing and new research area, has emerged. This interdisciplinary project, which examines the occupation period of Menemen, has been prepared to contribute to field. The goal of this study is to contribute methodologically to fields of history and historical geography by describing what happened during the occupation of Menemen (1919-1922) and mapping it using GIS.Öğe WHAT AWAITS US AFTER COVID-19? MUSCULOSKELETAL SYSTEM INVOLVEMENT IN THE ELDERLY POPULATION IN TURKIYE AND ITS AFTERMATH(Turkish Geriatrics Soc, 2024) Gokce-Kutsal, Yesim; Ordu-Gokkaya, Nilufer Kutay; Karahan, Sevilay; Irdesel, Fatma Jale; Paker, Nurdan; Ay, Saime; Binay-Safer, VildanIntroduction: Although COVID-19 primarily affects the respiratory system, one of the most frequently effected areas is the musculoskeletal system. COVID-19 associated musculoskeletal problems can cause disability in patients >= 65 years. The aim of the study was to define the musculoskeletal problems after the COVID-19 infection and to examine the relationship with the accompanying comorbidities in geriatric population. Materials and Method: The study was conducted by the members of Geriatric Rehabilitation Study Group of Turkish Physical Medicine and Rehabilitation Society at 11 different hospitals from 7 provinces (Ankara, stanbul, zmir, Gaziantep, Adana, Bursa, and Kirikkale) of Turkiye. Individuals aged 65 years and over who had a history of COVID-19 within the last 12 months and experienced persistent/continuous musculoskeletal complaints were included into the study. COVID-19 diagnoses were confirmed from electronic hospital records and the e-Nabiz system. Data were collected by face-to-face interviews and after recruiting the first 50 patients from each center, patient recruitment was terminated. Results: A total of 457 cases in which all questions were answered completely (without any missing data) were included in this observational study. The cases were mainly 65-75 years old, married, and non-smoking women. The most common musculoskeletal involvement was widespread pain (81%), followed by myalgia (63.7%) and arthralgia (44.4%). Other rare involvements (osteonecrosis, myositis, steroid myopathy, arthritis) were significantly more frequent in patients older than 75 years, regardless of gender. Analysis showed that musculoskeletal pain immediately after infection is observed more in cases with comorbid diseases (p<0.001), hypertension (p<0.001), pulmonary involvement (p=0.002) and hospitalization due to COVID-19 (p<0.001). It was determined that the incidence of pain seen immediately after infection increased as the number of comorbidities increased (p<0.001). In conjunction with this, persistent pain after COVID-19 infection were more common in those with osteoarthritis (p=0.039). Conclusion: Elderly patients may develop musculoskeletal pain in multiple body sites after COVID-19, which is primarily related to presence and number of comorbidities, hospitalization and pulmonary involvement. The long-term consequences of COVID-19 on musculoskeletal health are still being studied, and further research is needed to fully understand the extent and duration of these effects.Öğe ADOLESCENT FOOD PARENTING QUESTIONNAIRE: EVALUATION OF TURKISH PSYCHOMETRIC PROPERTIES OF PARENT AND ADOLESCENT VERSIONS(Dokuz Eylul Univ Inst Health Sciences, 2024) Kosem, Dilek Demir; Demir, Senay; Bektas, Murat; Bektas, Ilknur; Hayli, Cigdem Muge; Bor, Nese Ataman; Koning, MaaikePurpose: This study aimed to adapt the Adolescent Food Parenting Questionnaire: Parent and Adolescent Version into Turkish and conduct validity and reliability studies. Material and Methods: The research was carried out in methodological type and was carried out with 337 adolescents aged 12-16 years and their parents between June to September 2022. Data were collected with the Child and Parent Information Form and Adolescent Food Parent Questionnaire. Content validity, construct validity, internal consistency reliability, and item analysis were used to determine the questionnaire's psychometric properties. Results: Both parent and adolescent versions of the Adolescent Food Parenting Questionnaire contain 16 items. The results of the exploratory factor analysis determined that the five-factor structure explained 50.45% of the total Variance for the parent version and 63.31% of the total Variance for the adolescent version. In addition, item factor loads for the parent version ranged from 0.32 to 0.71, while item factor loads for the adolescent version ranged from 0.37 to 0.75. As a result of confirmatory factor analysis, the goodness of fit values of the parent version were chi 2/sd=2.030, RMSEA=0.055, GFI=0.94, CFI=0.95, IFI=0.95, RFI=0.87, NFI=0.90, TLI =0.93, and the adolescent version were chi 2/sd=1.672, RMSEA = 0.045, GFI = 0.95, CFI = 0.96, IFI = 0.96, RFI = 0.88, NFI = 0.91, and TLI = 0.95. The Cronbach alpha value for the entire parent version was 0.86, and the Cronbach alpha values for all sub- dimensions were determined to vary between 0.60 and 0.84. The adolescent version's overall cronbach alpha was determined to be 0.88, and the adolescent version's sub-dimension Cronbach alpha values were discovered to vary between 0.63 and 0.841. Conclusion: As a result of the research, it was determined that the Adolescent Food Parenting Questionnaire: Parent and Adolescent Version is a valid and reliable measurement tool to be used specifically for Turkish society.Öğe EVALUATION OF SOCIO-DEMOGRAPHIC FACTORS AND COMORBIDITIES IN ADULT HEMOPHILIA PATIENTS(Dokuz Eylul Univ Inst Health Sciences, 2024) Karadag, Fatma Keklik; Demirci, Zuhal; Koseoglu, Fatos Dilan; Saydam, Guray; Sahin, FahriPurpose: The association between socio-demographic factors and hemophilia status with the prevalence of comorbidities was evaluated. Material and Methods: Patients with hemophilia A (n=111) and B (n=24) who completed the questionnaire form about their socio-demographic factors were included in our study. Factor and inhibitor levels, comorbidities, factor replacement therapies, hemophilic arthropathy, viral status and annual bleeding episodes were recorded. Results: The median age was 39 years among 135 hemophilia patients, and 63.1% of all patients had severe hemophilia, which was significantly higher among hemophilia A (p=0.002). Most patients (74.8%) were treated with prophylactic factor replacement therapy. The inhibitor status was positive in 8.9% of all patients. The unemployment rate was found to be 33.3%. Annual bleeding episodes were higher in workers. Most patients (60%) had graduated from at least high school. Patients with severe hemophilia were significantly less educated than those with moderate to mild hemophilia (p=0.045). The prevalence of cardiovascular disease, hypertension, diabetes mellitus, and obesity was 6.7%; 17.8%, 13.3%, and 11.9% respectively. Although there was no association between obesity and annual bleeding episodes, right ankle was the most affected joint in overweight/obese patients. Conclusion: Age -related comorbidities and the relationship between hemophilia status and social life need further investigation.Öğe DOES SMARTPHONE ADDICTION IMPAIR MAXIMAL EXERCISE CAPACITY IN YOUNG ADULTS?(Dokuz Eylul Univ Inst Health Sciences, 2024) Zeren, Melih; Eroglu, Rumeysa; Sahin, Nilay Yurekdeler; Ozdemir, Kadirhan; Donmez, Batuhan; Karakum, EshanPurpose: Smartphone addiction may reduce the time allocated for physical activity participation. However, it is not known if there is a direct association between smartphone addiction and reduced exercise capacity. Our aim was to investigate whether smartphone addiction impairs maximal exercise capacity, as well as analyze its influence on the perceived benefits of exercise and physical activity habits in young adults. Material and Methods: Forty-six volunteers were evaluated by a symptom-limited incremental exercise test. Smartphone addiction of volunteers was evaluated using Smartphone Addiction Scale- Short Form. Physical activity participation and perceived benefits of physical activity participation were evaluated using International Physical Activity Questionnaire- Short Form and Exercise Benefits/Barriers Scale, respectively. Results: The prevalence of smartphone addiction was 65% in young adults. No significant association was detected between smartphone addiction and any of maximal exercise capacity metrics including test duration, maximum workload achieved in watts or maximum heart rate (p>0.05). Smartphone addiction did not correlate to physical activity participation either (p>0.05). Univariate linear regression revealed Exercise Benefits/Barriers Scale score was able to explain 41% of variance in exercise test duration and 37% of variance in maximal workload (p<0.01), and it was also correlated to physical activity level (r=0.424; p<0.01) Conclusion: Smartphone addiction did not directly translate into lower physical activity participation or worse exercise capacity. However, perception of the benefits of exercise had a great influence on physical activity and exercise capacity, which highlights the importance of increasing the awareness of the benefits of physical activity among young adults for maintaining physical health.Öğe The Reliability, Validityand Cross-Cultural Adaptation of Turkish Version of Jefferson Scale of Empathy for Health Professions Students(Marmara Univ, Inst Health Sciences, 2024) Ismailoglu, Elif Gunay; Ozdemir, Kadirhan; Tugral, Alper; Bakar, YesimObjective: The study is aimed to study for the reliability, validity, and cross-cultural adaptation of the Turkish version of the Jefferson Scale of Empathy for undergraduate health profession students (JSE-HPS). Methods: Cultural adaptation of JSE-HPS was carried out in 5 stages according to the protocol of Beaton et al.JSE-HPS was administered to students who educated in the departments of Physiotherapy and Rehabilitation, Nursing and Health Management. The reliability of JSE-HPS was evaluated by internal consistency and test -retest analysis using Cronbach's alpha and intraclass correlation coefficient (ICC), respectively. Criterion validity assessed by comparing the scores of JSE-HPS and Emphatic Tendency Scale (ETS). An analysis of construct validity was carried out by exploratory and confirmatory factor analysis. Results: The exploratory factor analysis revealed the presence of three factors that explain 44.68% of the total variance and that correspond to the dimensions of the original scale. Following factor structures were obtained as Perspective taking, Compassionate care and Standing in patient's shoes. Turkish version of JSE-HPS total score were significantly correlated with the ETS total score (r=0.187, p=.005). The Cronbach's Alpha internal consistency coefficient was found alpha = .793. The test -retest reliability coefficient was 0.86. The confirmatory factor analysis verified a good fit of the model (chi 2/df = 1.776). Conclusion: The Turkish version of JSE-HPS is a valid and reliable scale for evaluating empathy levels of undergraduate health professions students.Öğe THE ROLES OF IMMUNE MOLECULES IN THE ACUTE POST-TRANSPLANT PERIOD(Dokuz Eylul Univ Inst Health Sciences, 2024) Kocyigit, Asli Ozkizilcik; Pehlivan, Melek; Ayna, Tulay K.; Soyoz, Mustafa; Tatar, Erhan; Tanrisev, Mehmet; Sert, IsmailPurpose: Renal transplantation is a therapeutic choice that enhances the quality of life for patients suffering from end-stage renal failure. The objective of this study was to ascertain the alterations in the levels of immune molecules following transplantation and to examine the correlation between these changes and the medical records of the patients. Materials and Methods: : The gene expression of an immune molecule panel (FOXP3, TNF-alpha, IFN-gamma, IL- 18, IL-6, IL-17a, IL-12a, IL-2, IL-10, and TGF-beta) in peripheral blood specimens of 30 kidney transplant patients was determined by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) method with SYBR Green Dye. The serum proteins were quantified using Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: TGF-beta exhibited the most significant alteration in gene expression levels compared to the levels before transplanting (p<0.05). A strong association was seen between the change in IFN-gamma levels and the estimated glomerular filtration rate (eGFR) values of the patients (p<0.05). Conclusion: The cytokine expression alterations may provide information on patients' clinical condition. Individualized immune scanning after transplantations may contribute to personalized treatment of each patient. The communication between the laboratory and the clinics is important for the accurate consultation of the patients.Öğe THE PREDICTION OF HEALTH LITERACY OF PARENTS WHO HAVE CHILDREN WITH CANCER ON THEIR HEALTHCARE SATISFACTION(Dokuz Eylul Univ Inst Health Sciences, 2024) Kudubes, Asli Akdeniz; Bektas, Ilknur; Ayar, Dijle; Bektas, MuratPurpose: This study was a descriptive and cross-sectional study to examined the prediction of health literacy of parents having children with cancer on the healthcare satisfaction. Material and Methods: The descriptive and cross-sectional study was conducted between January and May 2019 and included 207 parents who had children treated at the pediatric hematology -oncology unit of a university hospital. A parental information form, the Health Literacy Index, and the Pediatric Quality of Life (PedsQL) Inventory Healthcare Satisfaction Hematology/Oncology Module parental report was used to collect the data. Percentage calculations, mean values, Pearson's correlation analysis, linear regression analysis, and multiple correlation analysis were used to analyze the data. Results: According to the relationship between variables in regression analysis, five models were created. Each subscale in the Health Literacy Index was identified as a separate model. In the last model, the effect of the total score of the Health Literacy Index on PedsQL Healthcare Satisfaction Hematology/Oncology Module was determined. According to these models, healthcare satisfaction increased as the health literacy subdimension scores and total scores increased. Increased scores of the Health Literacy Index were found to promote healthcare satisfaction. Conclusion: The ability of parents to manage their children's disease process and daily life activities becomes better as their health literacy levels increase.Öğe First dose optimization study on freezing Anatolian buffalo semen(Ankara Univ, 2024) Bastan, Ilktan; Sahin, Derya; Korkmaz, Firat; Simsek, Seher; Kaya, Ufuk; Satilmis, MuharremThe main objective of sperm production centers is to produce as many straws as possible from the obtained ejaculates using the optimal dilution rate. To this end, this study is the first to evaluate the effect of different semen extender rates on Anatolian buffalo semen quality. Ejaculates were collected by artificial vagina from three Anatolian buffalo bulls. These ejaculates were divided into three aliquots and filled into 0.25 ml straws with soy-based extenders at concentrations of 35, 25, and 15 million sperm/straw (n=105). The straw samples of different sperm concentrations were frozen. The quality of sperm was evaluated after thawing (37 degrees C, 30 sec) and following the thermoresistance test (37 degrees C, 3 h). The post-thaw total motility and progressive motility values were similar between the groups. However, following the thermoresistance test, there was a significant decrease in total motility in the 35 million sperm/straw group, and the progressive motility was significantly higher in the 25 million sperm/straw group. There was no statistically significant difference between the groups in terms of sperm kinetic parameters, except for VSL after thawing, as well as VAP and LIN values following the thermoresistance test. The overall mean PMAI and STR values were the highest in the 25 million sperm/straw group. In conclusion, it is recommended to dilute the Anatolian buffalo semen at a concentration of 25 million/0.25 ml when freezing it with a soy-based semen extender. In addition, it is considered that soy-based extenders compensate for cryo-damage to sperm motility for a short time, and the thermoresistance test should be applied for objective evaluation in dose optimization studies.Öğe The Impact of Geography and Occupation on the Perspective of the Good Death Among the Healthcare Professionals: A Cross-sectional Study(Galenos Publ House, 2024) Kocak, Fatma Ozge Kayhan; Cavdar, Sibel; Aygor, Hulya Eskiizmirli; Ozcaylak, Sueleyman; Saylan, Ertan; Sahin, Sevnaz; Yildirim, YaseminObjective: The aim of this study was to investigate the perspective of good death and related factors among healthcare professionals (HCPs), as well as to compare the perspective of good death regarding to live region and occupation. Materials and Methods: This cross-sectional study was performed one hundred ninety-five HCPs. The good death scale (GDS) was used to assess the perspective of HCPs on the concept of good death. Results: A total of 195 HCPs were included in this study. One hundred twenty-four (63.6%) participants were women. Ninety-eight (50.3%) and 95 (48.7%) of the participants were registered nurses and were living in the east, respectively. Seventy-five (38.5%) of the participants had 11 years or more of professional experience, and 132 (67.7%) of them grew up in the region where they worked. The mean score of all participants in GDS was 57.5 +/- 6.3, and the mean scores of the sub-dimensions were 30.9 +/- 3.8 for the psychosocial and spiritual sub-dimension, 10 +/- 1.9 for the personal control sub-dimension and 16.6 +/- 2.4 for the clinical sub-dimension. In multiple linear regression, living in the east, being a nurse, being a woman, and taking education on good death were positively related to the GDS score of the HCPs. Conclusion: Given the growing importance of good death, it is increasingly important to clarify the definitions and constantly raise awareness by providing appropriate education. In this study, the small number of participants and the inhomogeneous distribution of the sample by age, gender, occupation, and region could lead to potential biases and concerns about generalizability. It is recommended to conduct research using a scale to assess nurses' and doctors' perceptions of death in a more homogeneous and larger group.Öğe Impact of the HALP Score on Long-Term Mortality among Patients Undergoing EVAR(Galenos Publ House, 2024) Altunova, Mehmet; Evsen, Ali; Demir, Yusuf; Aktemur, Tugba; Erdogan, Onur; Atmaca, Sezgin; Koseoglu, MehmetIntroduction: Endovascular aortic repair (EVAR) is commonly used for abdominal aortic aneurysms, but its mortality rate remains high. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, which measures hemoglobin, albumin, lymphocyte, and platelet levels, provides prognostic value by reflecting the nutritional status and systemic inflammation. This study aimed to explore the relationship between the HALP score upon admission and long-term mortality in patients with EVAR. Methods: Consecutive patients with EVAR at our tertiary center from October 2010 to August 2021 were retrospectively analyzed. HALP scores were calculated using the following formula: hemoglobin (g/L) x albumin (g/L) x lymphocyte count (/L)/platelet count (/L). In-hospital and long-term mortality data were extracted. Receiver operating characteristic curve analysis identified predictors of in-hospital mortality. Multivariate Cox regression analysis was performed to examine determinants of long-term mortality. Results: Among the 162 participants (mean age: 69.4 +/- 8.2 years, 90.1% male), the HALP score was the most significant predictor of inhospital mortality (area under the curve: 0.752, 95% confidence interval: 0.674-0.830; p<0.001). Multivariate Cox regression analysis revealed HALP (p=0.001) and C-reactive protein (p=0.004) as independent determinants of long-term mortality. Conclusion: This study is the first to investigate the association between the HALP score and in-hospital and long-term mortality in EVAR patients. The HALP score is a robust prognostic tool compared with its components and other parameters in this patient population.Öğe Determinants of Conversion From Laparoscopic to Open Cholecystectomy: Türkiye Case(Galenos Publ House, 2024) Aslan, Huseyin; Cirakli, Umit; Ozden, Sabri; Cetin, EmineObjective: The aim of this study was to determine the characteristics of patients who required conversion from laparoscopic to open cholecystectomy. In addition, we compared the health outcomes of laparoscopic and converted cholecystectomy. Methods: This was a retrospective, cross-sectional study. The laparoscopic cholecystectomy procedures performed in hospitals of the Turkish Ministry of Health in 2016 were examined. Chi-square and Mann-Whitney U tests were used to analyze the data. Results: There were 103,387 laparoscopic cholecystectomy. Of these, 102,294 (98.9%) were laparoscopically completed, whereas 1,093 (1.1%) were converted to open cholecystectomy. The majority (75.9%) of the patients were female. The rate of conversion from laparoscopic to open cholecystectomy; in men >= 65 years of age, patients with chronic renal failure, hypertension, diabetes, malign neoplasm, and cerebrovascular disease were found to be statistically significantly higher than those in the opposing groups. Mortality, complications, intensive care unit treatment rates, and average hospitalization time were found to be statistically significant in cholecystectomy converted to open surgery. Conclusion: Patients who had converted cholecystectomy had more negative health outcomes than those who had completed the procedure laparoscopically. Old age, being male, and having comorbidities and malignancies increase the risk of conversion to open cholecystectomy. These factors can help determine the conversion risk of laparoscopic cholecystectomy to an open procedure.
