Effect of intraperitoneal and systemic sirolimus administration on postoperative peritoneal adhesions in rats
Yükleniyor...
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dokuz Eylul Univ Inst Health Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: Low incidence of surgery-induced peritoneal adhesions in posttransplant patients is a wellknown subject. The aim of this study was to investigate the role sirolimus to prevent intra-abdominal adhesions and compare the systemic and intraperitoneal efficacy of the intervention. Methods: A total of 21 male rats randomly constituted three groups as intraperitoneal 0.015mg/kg sirolimus administered group, 0.1 mg/kg oral sirolimus administered group, and control group. A surgical peritoneal adhesion model was performed. All rats were euthanized on postoperative 7. day for macroscopic adhesion evaluation and histopathologic examination. Results: Intraperitoneal sirolimus administration significantly reduced adhesion formation. On the other hand, one-dose systemic administration did not show significant difference compared with control group. Conclusions: Intraperitoneal sirolimus administration at therapeutic doses significantly reduces postoperative intraabdominal adhesions in rat model.
Açıklama
Anahtar Kelimeler
Surgery-Induced Tissue Adhesions, Sirolimus, Surgical Adhesions, Postsurgical Adhesions, Abdominal Adhesions, Prevention, Antibodies, Interleukin-6, Reduction, Rapamycin, Therapy, Model
