The prognostic value of F-18-FDG PET/CT metabolic parameters in predicting treatment response before EGFR TKI treatment in patients with advanced lung adenocarcinoma

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dc.authorwosidAgüloğlu, Nurşin/HPB-8618-2023
dc.contributor.authorAgüloğlu, Nurşin
dc.contributor.authorAkyol, Murat
dc.contributor.authorKomek, Halil
dc.contributor.authorKatgı, Nuran
dc.date.accessioned2023-03-22T19:47:18Z
dc.date.available2023-03-22T19:47:18Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractObjectives: This study makes a retrospective examination of exploring the prognostic value of (18)fluorine-fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) related metabolic-volumetric variables, nutritional status, and immune and inflammatory markers on progression-free survival (PFS) and overall survival (OS) in advanced adenocarcinoma patients with positive epidermal growth factor receptor (EGFR) mutations undergoing EGFR tyrosine kinase inhibitor (TKI) therapy. Methods: A retrospective examination was made of patients diagnosed with lung adenocarcinoma who underwent F-18-FDG PET/CT imaging for staging maximum four weeks before starting treatment, between January 2015 and July 2020. Included in the study were 68 patients identified histopathologically to have locally advanced/metastatic EGFR mutation-positive adenocarcinoma, and who underwent EGFR TKI therapy. The laboratory data of the patients, obtained 15 days before imaging performed for PET/CT staging, were evaluated. Results: Metabolic tumor volume, modified Glasgow prognostic score and locally advanced disease were identified as independent prognostic parameters for PFS (p= 0.004, p=0.029, p=0.016, respectively). A univariate Cox regression analysis revealed albumin/alkaline phosphatase and tumor size to be significant parameters for prognosis (p=0.033, p=0.043, respectively). A multivariate Cox regression analysis revealed that none of the parameters were predictive or OS. Conclusion: The parameters of F-18-FIDG PET/CT, especially the volumetric parameters, were found to be strong prognostic factors with statistical significance for predicting PFS. We believe that these parameters are important prognostic markers that should be evaluated together in the management and follow-up of patients with EGFR mutation-positive adenocarcinoma.en_US
dc.identifier.doi10.4274/mirt.galenos.2022.24650
dc.identifier.endpage113en_US
dc.identifier.issn2146-1414
dc.identifier.issn2147-1959
dc.identifier.issue2en_US
dc.identifier.pmid35770976en_US
dc.identifier.scopus2-s2.0-85134079115en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage104en_US
dc.identifier.trdizinid535057en_US
dc.identifier.urihttps://doi.org/10.4274/mirt.galenos.2022.24650
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/535057
dc.identifier.urihttps://hdl.handle.net/20.500.14034/601
dc.identifier.volume31en_US
dc.identifier.wosWOS:000823262600005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.journalMolecular Imaging And Radionuclide Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectF-18-FDG PET/CTen_US
dc.subjectlung canceren_US
dc.subjectadenocarcinomaen_US
dc.subjectEGFRen_US
dc.subjectprogression-free survivalen_US
dc.subjectoverall survivalen_US
dc.subjectPositron-Emission-Tomographyen_US
dc.subjectNeutrophil-Lymphocyte Ratioen_US
dc.subjectReceptor Gene-Mutationsen_US
dc.subjectVolumetric Parametersen_US
dc.subjectFdg-Peten_US
dc.subjectCanceren_US
dc.subjectGefitiniben_US
dc.subjectInflammationen_US
dc.subjectErlotiniben_US
dc.subjectChemotherapyen_US
dc.titleThe prognostic value of F-18-FDG PET/CT metabolic parameters in predicting treatment response before EGFR TKI treatment in patients with advanced lung adenocarcinomaen_US
dc.typeArticleen_US

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