The comparison of exacerbation and pneumonia before and after conjugated pneumococcal vaccination in patients with chronic obstructive pulmonary disease, and the effect of inhaled corticosteroid use on results

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dc.authoridGUCSAV, MUTLU ONUR/0000-0003-2969-4766
dc.authoridKaradeniz, Gulistan/0000-0002-1994-6723
dc.authoridPolat, Gulru/0000-0002-2211-1268
dc.contributor.authorSahin, Gorkem Vayisoglu
dc.contributor.authorKaradeniz, Gulistan
dc.contributor.authorPolat, Gulru
dc.contributor.authorYalniz, Enver
dc.contributor.authorAyrancı, Aysu
dc.contributor.authorUcsular, Fatma Demirci
dc.contributor.authorGucsav, Mutlu Onur
dc.date.accessioned2023-03-22T19:47:19Z
dc.date.available2023-03-22T19:47:19Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractThe comparison of exacerbation and pneumonia before and after conjugated pneumococcal vaccination in patients with chronic obstructive pulmonary disease, and the effect of inhaled corticosteroid use on results Introduction: Pneumococcal infections and exacerbations are important causes of mortality and morbidity in chronic obstructive pulmonary disease (COPD). The use of inhaled corticosteroids and pneumococcal vaccination are suggested for the control of the disease progression and exacerbations. The aim of this study is to assess the effect of pneumococcal conjugate vaccine on pneumonia and exacerbation in COPD patients using inhaled corticosteroids (ICSs). The secondary aim is to analyze the effect of ICS use and different ICS types, if administered, on exacerbation and pneumonia incidence in the study population. Materials and Methods: Medical records of 108 adult patients with COPD who were vaccinated with the pneumococcal conjugate vaccine (PCV13) were retrospectively evaluated. The number of acute exacerbations and pneumonia within one year before and after vaccination were evaluated in all included COPD patients. The comparison analysis was also performed based on the ICS types. Results: There were statistically significant differences between the mean numbers of pneumonia and exacerbations before and after vaccination (p< 0.05). There were no significant differences in the mean pneumonia attacks and acute exacerbations between patients using ICS and not using ICS (p> 0.05). Conclusion: This study revealed that PCV13 provides a significant decrease in both exacerbation and pneumonia episodes in COPD patients. On the other hand, the use of ICSs and the types of ICSs were not found to have adverse effects on pneumonia and acute exacerbations in vaccinated COPD patients.en_US
dc.identifier.doi10.5578/tt.20229805
dc.identifier.endpage156en_US
dc.identifier.issn0494-1373
dc.identifier.issue2en_US
dc.identifier.pmid35785879en_US
dc.identifier.scopus2-s2.0-85133232874en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage149en_US
dc.identifier.trdizinid531232en_US
dc.identifier.urihttps://doi.org/10.5578/tt.20229805
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/531232
dc.identifier.urihttps://hdl.handle.net/20.500.14034/609
dc.identifier.volume70en_US
dc.identifier.wosWOS:000822096200005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Tuberculosis & Thoraxen_US
dc.relation.journalTuberkuloz Ve Toraks-Tuberculosis And Thoraxen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectvaccinationen_US
dc.subjectpneumococcal conjugate vaccineen_US
dc.subjectinhaled corticosteroidsen_US
dc.subjectvaccination in chronic obstructive pulmonary diseaseen_US
dc.subjectCopden_US
dc.subjectAdultsen_US
dc.subjectRisken_US
dc.subjectGolden_US
dc.titleThe comparison of exacerbation and pneumonia before and after conjugated pneumococcal vaccination in patients with chronic obstructive pulmonary disease, and the effect of inhaled corticosteroid use on resultsen_US
dc.typeArticleen_US

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