The effect of positive pressure ventilation on serum ischemia-modified albumin levels in obese patients with obstructive sleep apnea syndrome

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dc.authoridBasok, Banu Isbilen/0000-0002-1483-997X
dc.contributor.authorAjun, Ebru Gamze
dc.contributor.authorUçar, Zeynep Zeren
dc.contributor.authorArslan, Burcu Oktay
dc.contributor.authorKarakoyun,İnanç
dc.contributor.authorErbaycu, Ahmet Emin
dc.contributor.authorBaşok, Banu İşbilen
dc.date.accessioned2023-03-22T19:47:37Z
dc.date.available2023-03-22T19:47:37Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractIntroduction: Respiratory abnormalities in obstructive sleep apnea syndrome (OSAS) are corrected with positive pressure ventilation treatments. We inves-tigated the effect of positive airway pressure (PAP) treatment on the serum level of ischemia-modified albumin (IMA), an oxidative stress product, in OSAS patients with higher body mass index (BMI) and indication for PAP treatment.Materials and Methods: Seven consecutive female and 23 male patients with a BMI of >= 30 kg/m2 who were diagnosed as having OSAS according to ICSD-3 criteria and were planned for PAP, were included. The Epworth Sleepiness Scale and STOP-Bang Questionnaire were performed. Morning arterial blood gas, hemogram, biochemistry, insulin, and IMA were measured after polysom-nography and after three months of PAP.Results: There were no significant changes in lactate, CRP, and serum elect-rolyte levels measured before and after PAP, except for potassium. When 30 patients were compared in terms of serum IMA levels at baseline and after treatment, the mean baseline value was 0.56 absorbance units (ABSU), and the 3rd-month follow-up IMA value was 0.53 ABSU (p= 0.537). The mean serum fasting insulin level was 15.85 mu IU/mL and 11.6 (p= 0.002) and the mean HOMA index was 4.4 and 3.0 (p= 0.001), respectively.Conclusion: Serum IMA levels seem not to be an appropriate marker for the evaluation of PAP treatment in OSAS patients with higher BMI. PAP is associ-ated with a decrease in the fasting insulin level, HOMA index, and hematocrit, but not with serum electrolytes except potassium.en_US
dc.identifier.doi10.5578/tt.20229602
dc.identifier.endpage323en_US
dc.identifier.issn0494-1373
dc.identifier.issue4en_US
dc.identifier.pmid36537088en_US
dc.identifier.scopus2-s2.0-85143815467en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://doi.org/10.5578/tt.20229602
dc.identifier.urihttps://hdl.handle.net/20.500.14034/796
dc.identifier.volume70en_US
dc.identifier.wosWOS:000903921600002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Tuberculosis & Thoraxen_US
dc.relation.journalTuberkuloz Ve Toraks-Tuberculosis And Thoraxen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia-modified albuminen_US
dc.subjectobstructive sleep apnea syndromeen_US
dc.subjectpositive pressure ventilationen_US
dc.subjectScaleen_US
dc.subjectHypoxiaen_US
dc.subjectCpapen_US
dc.titleThe effect of positive pressure ventilation on serum ischemia-modified albumin levels in obese patients with obstructive sleep apnea syndromeen_US
dc.typeArticleen_US

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