Does heated erythrocyte suspension transfusion with medical devices containing phthalates increase DEHP and MEHP levels?

Basit Öğe Kaydı
dc.authoridGonullu, Hayriye / 0000-0002-9587-6261
dc.authoridGonullu, Edip / 0000-0002-7751-3758
dc.authoridKume, Tuncay / 0000-0003-3440-3513
dc.authoridTasdogen, Aydin / 0000-0003-4406-0745
dc.authorscopusid55554281100
dc.authorscopusid57208803348
dc.authorscopusid6507617532
dc.authorscopusid36096565100
dc.authorscopusid6602551945
dc.authorscopusid57226413630
dc.authorscopusid56893542800
dc.authorwosidGonullu, Hayriye/AAU-9606-2021
dc.authorwosidGonullu, Edip/AAV-7377-2021
dc.contributor.authorGönüllü, Edip
dc.contributor.authorBilvanisi, Sevdegul
dc.contributor.authorTasdogen, Aydin
dc.contributor.authorGönüllü, Hayriye
dc.contributor.authorErkin, Yüksel
dc.contributor.authorKume, Tuncay
dc.contributor.authorAykac, Mehmet Coşkun
dc.date.accessioned2022-02-15T16:57:46Z
dc.date.available2022-02-15T16:57:46Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractAims It is commonly known that stored blood and blood products are heated before transfusion to prevent hypothermia, which leads to increased di-(2-ethylhexyl) phthalate (DEHP) content leaching into the blood and blood products and thereby causes greater conversion of DEHP to mono (2-ethylhexyl) phthalate (MEHP). However, there has been no study in the literature reporting on the amount of toxic phthalates in blood following the erythrocyte suspension (ES) transfused via warming. In this study, we aimed to investigate the DEHP and MEHP content in blood following the heated ES transfusions administered by DEHP-containing and DEHP-free infusion sets. Methods The study included 30 patients that were randomly divided into two groups with 15 patients each: group I underwent ES transfusion via DEHP-containing infusion sets warmed with blood-fluid warmers, and group II underwent ES transfusion via DEHP-free infusion sets warmed with blood-fluid warmers. DEHP and MEHP levels were measured both before and after transfusion. Results DEHP-free infusion sets led to no increase in the phthalate content, whereas DEHP-containing infusion sets significantly increased the DEHP and MEHP, where the DEHP level increased almost four times (P = .001). Conclusion DEHP-containing products lead to toxicity. Therefore, using DEHP-free medical devices may prevent toxicity in patients undergoing ES transfusion.en_US
dc.description.sponsorshipYuzuncu Yil University Individual Research ProjectYuzuncu Yil University [2013-TF-B029]en_US
dc.description.sponsorshipYuzuncu Yil University Individual Research Project (2013-TF-B029)en_US
dc.identifier.doi10.1111/ijcp.14603
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.pmid34229364en_US
dc.identifier.scopus2-s2.0-85111486023en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/ijcp.14603
dc.identifier.urihttps://hdl.handle.net/20.500.14034/270
dc.identifier.wosWOS:000679456600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal Of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDi-(2-Ethylhexyl) Phthalateen_US
dc.subjectDi-2-Ethylhexyl Phthalateen_US
dc.subjectExposureen_US
dc.subjectMetabolitesen_US
dc.subjectHealthen_US
dc.subjectPlasticizeren_US
dc.subjectRelevanceen_US
dc.subjectToxicityen_US
dc.subjectRisksen_US
dc.titleDoes heated erythrocyte suspension transfusion with medical devices containing phthalates increase DEHP and MEHP levels?en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Does heated erythrocyte suspension transfusion with medical devices containing phthalates increase DEHP and MEHP levels.pdf
Boyut:
609.71 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu