Effect of latanoprost on choroidal thickness in patients with newly diagnosed primary open-angle glaucoma

Basit Öğe Kaydı
dc.contributor.authorBuyukmurat, Neslihan
dc.contributor.authorKaradag, Erdi
dc.contributor.authorOzbek, Hanefi
dc.date.accessioned2025-03-20T09:50:37Z
dc.date.available2025-03-20T09:50:37Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractOBJECTIVE: The purpose of this study was to assess the influence of latanoprost on choroidal thickness in patients with newly diagnosed primary open-angle glaucoma using Swept-Source Optical Coherence Tomography (SS-OCT). METHODS: The retrospective, non-randomized study comprised 40 newly diagnosed primary open-angle glaucoma patients receiving latanoprost therapy (Group 1). Additionally, 40 age- and sex-matched healthy subjects served as the control group (Group 2). Using SS-OCT, measurements of subfoveal, horizontal temporal, and horizontal nasal quadrants choroidal thickness, as well as intraocular pressure (IOP) and retinal nerve fiber layer (RNFL) thickness values, were collected at baseline and after 1 month for both groups. RESULTS: The mean age was 39.8 +/- 4.15 years (range: 18-45 years) in group 1 and 41.67 +/- 7.95 years (range: 18-45 years) in group 2 (p>0.05). The mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant prior to latanoprost therapy were 263.57 +/- 84.23 mu m, 233.05 +/- 80.08 mu m, and 219.52 +/- 83.28 mu m in the group 1 whereas 278.9 +/- 93.88 mu m, 243.8 +/- 73.37 mu m and 209.85 +/- 92.92 mu m in the group 2. After latanoprost therapy, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant changed significantly to 299.77 +/- 41.29 mu m, 269.9 +/- 43.80 mu m, and 261.32 +/- 45.60 mu m in the group 1 (p=0.02, p=0.016, and p=0.012, respectively) (Table 1). However, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant and horizontal nasal quadrant in group 2 changed not significant and was 279.25 +/- 103.37 mu m, 246.42 +/- 87.07 mu m and 203.62 +/- 106.74 mu m, respectively (p=0.4, p=0.5 and p=0.9, respectively). The mean IOP decreased significantly in group 1 (p=0.000) but did not change significantly in group 2 (p=0.153). There was no difference in RNFL thickness values at baseline and 1 st month in group 1 and group 2 (p>0.05). CONCLUSION: Topical latanoprost may increase choroidal thickness. Swept Source-OCT may contribute to our understanding of the actions of latanoprost on choroidal thickness.
dc.identifier.doi10.14744/nci.2024.87405
dc.identifier.endpage276
dc.identifier.issn2148-4902
dc.identifier.issn2536-4553
dc.identifier.issue4
dc.identifier.pmid39165701
dc.identifier.scopus2-s2.0-85202198033
dc.identifier.scopusqualityQ4
dc.identifier.startpage271
dc.identifier.trdizinid1280448
dc.identifier.urihttps://doi.org/10.14744/nci.2024.87405
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1280448
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2276
dc.identifier.volume11
dc.identifier.wosWOS:001290316200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofNorthern Clinics of Istanbul
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjectChoroidal thickness
dc.subjectglaucoma
dc.subjectlatanoprost
dc.subjectswept source optical coherence tomography
dc.titleEffect of latanoprost on choroidal thickness in patients with newly diagnosed primary open-angle glaucoma
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu