Vitamin D Levels and Their Relationship with Ambulation in Patients with Amyotrophic Lateral Sclerosis

dc.authoridSERTPOYRAZ, FILIZ MERYEM/0000-0001-5247-6412
dc.contributor.authorSertpoyraz, Filiz Meryem
dc.contributor.authorArslan, Fatma Demet
dc.date.accessioned2025-03-20T09:50:27Z
dc.date.available2025-03-20T09:50:27Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractObjective: Vitamin D is a steroid hormone that exerts many effects on human health. Amyotrophic lateral sclerosis is a progressive neurodegenerative disease characterized by the loss of motor neurons. This can result in a number of complications, including muscle weakness, spasticity, difficulty swallowing, speech disturbances, and, in some cases, respiratory failure. A number of studies have reported an association between vitamin D and various neurological diseases. This study aimed to assess vitamin D levels in patients diagnosed with amyotrophic lateral sclerosis and compare them with those of a control group comprising healthy individuals. In addition, the correlation between vitamin D levels and functional ambulation levels will be examined. Materials and Methods: This retrospective cross-sectional study was conducted involving 29 male and female patients diagnosed with definite amyotrophic lateral sclerosis using the El Escorial criteria and 28 healthy controls from the physical medicine and rehabilitation clinic of medicine. The medical records of the patients were consulted to obtain relevant demographic, clinical, and vitamin D levels. Subsequently, vitamin D levels were compared with those of healthy controls. Results: The results are presented in the following section. The mean vitamin D level observed in the patient group with amyotrophic lateral sclerosis was 20.21 +/- 9.53, while in the healthy control group, it was 26.69 +/- 8.90. A statistically significant difference in vitamin D levels was observed between the two groups (p=0.034). No correlation was observed between patients' ambulation levels and vitamin D levels (p=0.202). Conclusion: It can be concluded that patients with amyotrophic lateral sclerosis are at risk of vitamin D deficiency or insufficiency. It is therefore recommended that regular vitamin D levels are measured and treatment plans are developed for these patients.
dc.description.sponsorshipAcknowledgements: We would like to express our gratitude to Dr. rem Tiftikciolu for her invaluable contributions to this study.
dc.identifier.doi10.4274/tod.galenos.2024.37880
dc.identifier.endpage130
dc.identifier.issn2147-2653
dc.identifier.issue2
dc.identifier.scopusqualityN/A
dc.identifier.startpage126
dc.identifier.urihttps://doi.org/10.4274/tod.galenos.2024.37880
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2202
dc.identifier.volume30
dc.identifier.wosWOS:001293237800009
dc.identifier.wosquality#YOK
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofTurk Osteoporoz Dergisi-Turkish Journal of Osteoporosis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjectAmyotrophic lateral sclerosis
dc.subjectvitamin D
dc.subjectambulation
dc.titleVitamin D Levels and Their Relationship with Ambulation in Patients with Amyotrophic Lateral Sclerosis
dc.typeArticle

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