What are the differences between smoker and non-smoker COPD cases? is it a different phenotype?

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dc.authoridAyranci, Aysu/AAV-7986-2021
dc.contributor.authorGüldaval, Filiz
dc.contributor.authorPolat, Gülru
dc.contributor.authorDoruk, Sibel
dc.contributor.authorKaradeniz, Gülistan
dc.contributor.authorAyrancı, Aysu
dc.contributor.authorTürk, Merve
dc.contributor.authorAnar, Ceyda
dc.date.accessioned2022-02-15T16:57:49Z
dc.date.available2022-02-15T16:57:49Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractOBJECTIVE: The most important risk factor for chronic obstructive pulmonary disease (COPD) is smoking. However, more than 25% of patients do not have a history of smoking. The intent of this study is to identify characteristics of COPD patients that are non-smokers.MATERIAL AND METHODS: The records of patients with COPD were retrospectively reviewed. Smoking history, comorbidities, exacerbations, biomass, and environmental tobacco smoke (ETS) exposures were identified. Also, age, gender, pulmonary function test (PFT) values, modified Medical Research Council (mMRC) dyspnea scores were recorded. Non-smokers exposed to any of the COPD risk factors above were grouped and the data were analyzed to determine the specific characteristics of COPD that applied to them.RESULTS: A total of 706 COPD patients were analyzed with a mean age of 67.2 ± 9.4. Of these patients, 93 (13.2%) were female and 613 (86.8%) were male. Of the 706 patients, 128 (18.1%) were non-smokers. The percentage of male patients having COPD was significantly lower in the non-smoker group (P < .001). However, biomass, ETS exposure in childhood, and a history of previous respiratory infection were significantly higher in the non-smoker group (P < .001). The mean body mass index (BMI) was greater in non-smokers than smokers.CONCLUSION: Non-smokers with COPD have more biomass, ETS exposure, and infection history in childhood. They also have less impairment of airflow limitation, better symptom scores, and greater BMIs. Smoking history can be used to determine a different phenotype.en_US
dc.identifier.doi10.5152/TurkThoracJ.2021.20147
dc.identifier.endpage288en_US
dc.identifier.issn2149-2530
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85109321740en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage284en_US
dc.identifier.trdizinid457771
dc.identifier.urihttps://doi.org/10.5152/TurkThoracJ.2021.20147
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRVM056Y3hNUT09
dc.identifier.urihttps://hdl.handle.net/20.500.14034/280
dc.identifier.volume22en_US
dc.identifier.wosWOS:000672640800003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.journalTurkish Thoracic Journalen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectsmokeren_US
dc.subjectnon-smokeren_US
dc.subjectObstructive Pulmonary-Diseaseen_US
dc.subjectRisk-Factorsen_US
dc.subjectGlobal Burdenen_US
dc.subjectPrevalenceen_US
dc.subjectCohorten_US
dc.titleWhat are the differences between smoker and non-smoker COPD cases? is it a different phenotype?en_US
dc.typeArticleen_US

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