Effect of Colchicine on Secondary Acute Lung Injury in an Experimental Sepsis Model in Rats

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dc.authoridYILMAZ, Osman/0000-0001-7817-7576
dc.authorwosidYILMAZ, Osman/V-3632-2019
dc.contributor.authorCeylan, Mehmet
dc.contributor.authorKose, Sukran
dc.contributor.authorYilmaz, Hueseyin Oguz
dc.contributor.authorAktas, Safiye
dc.contributor.authorYilmaz, Osman
dc.date.accessioned2024-03-09T18:48:49Z
dc.date.available2024-03-09T18:48:49Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractIntroduction: An irregular systemic inflammatory response in sepsis can induce acute lung injury (ALI), which is characterized by the exaggerated inflammation of the lung tissue. Colchicine inhibits several inflammatory pathways which may prevent sepsis-induced secondary lung injury. We aimed to examine the histopathological effects of colchicine on lung tissue in a lipopolysaccharide (LPS)-induced sepsis model in rats.Materials and Methods: Twenty-eight rats were randomly divided into the following four groups: sham (n=6), colchicine only (n=6), sepsis only (n=8) and sepsis+colchicine (n=8). In the sham group, 0.9% NaCl was administered intraperitoneally (IP) and intragastrically (IG). In the Colchicine only group, 0.9% NaCl was administered IP and colchicine was administered IG. Sepsis was induced in the sepsis only and sepsis+colchicine groups by administering of 1 mg/kg of LPS IP at the 0-time point. In the sepsis+colchicine group, colchicine was additionally given IG at the 90th minute. An observational sepsis scoring system was used to evaluate the signs of sepsis. Subsequently, the rats were sacrificed at the 24th hour. The lung tissues were examined according to the American Thorax Association's assessment report on ALI in animals.Results: The histopathological lung injury score in the sepsis+colchicine group was significantly higher than in the sham group (0.23 +/- 0.18 vs. 0 +/- 0; p<0.05) and was significantly lower than in the sepsis only group (0.23 +/- 0.18 vs. 0.57 +/- 0.14; p<0.001). Evaluation of the lung damage score revealed that colchicine suppressed the increase in alveolar and interstitial neutrophil counts and limited the increase in hyaline membrane counts and alveolar wall thickness in the sepsis+colchicine group when compared with the sepsis only group.Conclusion: In our experimental sepsis rat model, administration of colchicine for sepsis limited the secondary lung damage.en_US
dc.description.sponsorshipUniversity of Health Sciences Turkeyen_US
dc.description.sponsorshipThis study was funded as a Scientific Research Project by University of Health Sciences Turkey.en_US
dc.identifier.doi10.4274/mjima.galenos.2023.2023.30
dc.identifier.issn2147-673X
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.4274/mjima.galenos.2023.2023.30
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1497
dc.identifier.volume12en_US
dc.identifier.wosWOS:001134784600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofMediterranean Journal of Infection Microbes and Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSepsis; Acute Lung Injury; Colchicine; Rat Modelen_US
dc.titleEffect of Colchicine on Secondary Acute Lung Injury in an Experimental Sepsis Model in Ratsen_US
dc.typeArticleen_US

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