Assessment of the cardiorespiratory fitness and the quality of life of patients with breast cancer undergoing chemotherapy: a prospective study

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dc.authoridTuğral, Alper/0000-0002-8017-2384
dc.authoridAribas, Zeynep/0000-0003-0469-6917
dc.authoridBakar, Yesim/0000-0002-5603-2891
dc.authorwosidTuğral, Alper/IZQ-1753-2023
dc.authorwosidAribas, Zeynep/HZJ-8329-2023
dc.contributor.authorAkyol, Murat
dc.contributor.authorTugral, Alper
dc.contributor.authorAribas, Zeynep
dc.contributor.authorBakar, Yesim
dc.date.accessioned2024-03-09T18:48:17Z
dc.date.available2024-03-09T18:48:17Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractBackgroundDiminished cardiorespiratory fitness is a well-known side effect of chemotherapy as well as a risk factor for potential cardiovascular diseases among cancer patients. This study aimed to assess the potential effects of systemic adjuvant (ACT) or neoadjuvant (NACT) chemotherapy on cardiorespiratory fitness and quality of life (QoL) among breast cancer (BC) patients.MethodsDemographic data, cardiorespiratory fitness, health-related QoL domains were assessed with simple data form, six-minute walk test (6MWT), European Organization for Research and Treatment of Cancer quality of life module (EORTC-C30), and Functional Assessment of Cancer Therapy (FACT-B+), respectively. Time1 (T1, prior to chemotherapy), Time2 (T2; interim assessment), and Time3 (T3, final assessment) were set as assessment points.ResultsA total of 42 patients (32 ACT vs 10 ACT) completed all assessments. There were no significant differences of main effect of time and time*group interaction on total walked distance (TWD) after controlling for age and BMI (F(2,28) = 1.309, p = 0.286; F(2,28) = 1.444, p = 0.253). EORTC symptoms subscale was found to be correlated with EORTC and FACT-B+ physical function (PF) subscales (r = - 861, p < 0.001; r = - 0.877, p < 0.001) in T3. The EORTC PF subscale was found to be correlated with the TWD in the baseline (r = 0.411, p = 0.024).ConclusionsThis study showed that the effect of chemotherapy on diminished PF and remarkably increased symptom burden among BC patients. Yet, the type of chemotherapy had no effect on TWD regarding cardiorespiratory fitness. Monitoring potential functional decline regarding cardiorespiratory fitness can be performed via simple field tests such as 6MWT.en_US
dc.identifier.doi10.1007/s12282-023-01453-6
dc.identifier.endpage626en_US
dc.identifier.issn1340-6868
dc.identifier.issn1880-4233
dc.identifier.issue4en_US
dc.identifier.pmid36952220en_US
dc.identifier.scopus2-s2.0-85150649560en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage617en_US
dc.identifier.urihttps://doi.org/10.1007/s12282-023-01453-6
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1273
dc.identifier.volume30en_US
dc.identifier.wosWOS:000951823600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofBreast Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Cancer; Six-Minute Walk Test; Cardiotoxicity; Chemotherapy; Quality Of Lifeen_US
dc.titleAssessment of the cardiorespiratory fitness and the quality of life of patients with breast cancer undergoing chemotherapy: a prospective studyen_US
dc.typeArticleen_US

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