THE ROLES OF IMMUNE MOLECULES IN THE ACUTE POST-TRANSPLANT PERIOD

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dc.authoridKilicaslan Ayna, Tulay/0000-0001-7993-978X
dc.authoridTugmen, Cem/0000-0002-2668-5197
dc.authoridSoyoz, Mustafa/0000-0001-5159-6463
dc.authoridtatar, erhan/0000-0002-5068-4231
dc.contributor.authorKocyigit, Asli Ozkizilcik
dc.contributor.authorPehlivan, Melek
dc.contributor.authorAyna, Tulay K.
dc.contributor.authorSoyoz, Mustafa
dc.contributor.authorTatar, Erhan
dc.contributor.authorTanrisev, Mehmet
dc.contributor.authorSert, Ismail
dc.date.accessioned2025-03-20T09:50:33Z
dc.date.available2025-03-20T09:50:33Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractPurpose: Renal transplantation is a therapeutic choice that enhances the quality of life for patients suffering from end-stage renal failure. The objective of this study was to ascertain the alterations in the levels of immune molecules following transplantation and to examine the correlation between these changes and the medical records of the patients. Materials and Methods: : The gene expression of an immune molecule panel (FOXP3, TNF-alpha, IFN-gamma, IL- 18, IL-6, IL-17a, IL-12a, IL-2, IL-10, and TGF-beta) in peripheral blood specimens of 30 kidney transplant patients was determined by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) method with SYBR Green Dye. The serum proteins were quantified using Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: TGF-beta exhibited the most significant alteration in gene expression levels compared to the levels before transplanting (p<0.05). A strong association was seen between the change in IFN-gamma levels and the estimated glomerular filtration rate (eGFR) values of the patients (p<0.05). Conclusion: The cytokine expression alterations may provide information on patients' clinical condition. Individualized immune scanning after transplantations may contribute to personalized treatment of each patient. The communication between the laboratory and the clinics is important for the accurate consultation of the patients.
dc.description.sponsorshipProjects of Izmir Katip Celebi University Scientific Research Projects Coordination [2019-GAP-TIPF-0006, 2020-TDR-SABE-011]
dc.description.sponsorshipThis study was supported by the projects of Izmir Katip Celebi University Scientific Research Projects Coordination (Project No: 2019-GAP-TIPF-0006 and 2020-TDR-SABE-011) .
dc.identifier.doi10.30621/jbachs.1481461
dc.identifier.endpage641
dc.identifier.issn2458-8938
dc.identifier.issn2564-7288
dc.identifier.issue3
dc.identifier.scopusqualityN/A
dc.identifier.startpage634
dc.identifier.trdizinid1274278
dc.identifier.urihttps://doi.org/10.30621/jbachs.1481461
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1274278
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2253
dc.identifier.volume8
dc.identifier.wosWOS:001334630400014
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherDokuz Eylul Univ Inst Health Sciences
dc.relation.ispartofJournal of Basic and Clinical Health Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjectkidney transplantation
dc.subjectreal-time pcr
dc.subjectcytokine
dc.subjectgene expression
dc.titleTHE ROLES OF IMMUNE MOLECULES IN THE ACUTE POST-TRANSPLANT PERIOD
dc.typeArticle

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