Thyroid hormone replacement in total thyroidectomized patients: Symptomatic and metabolic effects of levothyroxine monotherapy

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dc.authorwosidDereli Akdeniz, Didem/ABD-1198-2021
dc.contributor.authorAkdeniz, Didem Dereli
dc.contributor.authorÖztop, Mehmet Burak
dc.date.accessioned2022-02-15T16:57:16Z
dc.date.available2022-02-15T16:57:16Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractPurpose: In this study, we planned to investigate the effects of L-thyroxine monotherapy on total thyroidectomized patients. The main goal of our study is to evaluate if FT4 therapy is good enough not only to maintain euthyroidism but also to provide a good quality of life and a balance in their metabolism Methods: In this study, we retrospectively evaluated 30 total thyroidectomized patients without malignancy. We compared their thyroid hormone levels, glucose metabolism, lipid metabolism, their body mass indexes, and their symptoms of thyroid problems before surgery and after one year of treatment of L-thyroxine monotherapy. Results: the pre-op and post-op thyroid hormone levels were both in the normal range but the FT4 levels were significantly higher in the 1st year results than pre-op results (1,42 +/- 0,18 vs 1,29 +/- 0,49 respectively P=0,005*) The FT3 levels also were in the normal range in pre and 1st year post-op but post-op FT3 levels were significantly lower than pre-op levels (2,25 +/- 0,27 vs 2,92 +/- 0,49 retrospectively P<0,001*). The pre-op and postop TSH levels were euthyroid and not statistically significant. The patients tended to gain weight and it seems to be because of a tendency of being insulin resistant. (HOMA-IR pre-op and post-op were 2,2 +/- 1,1 vs 2,6 +/- 1,1 P<0,01 retrospectively; pre-op and post-op weights were 69,8 +/- 9,5 vs 71,1 +/- 10,3 P=0,006* respectively). Even all of them were euthyroid the patients tended to feel hypothyroidism symptoms. Conclusion: This study demonstrates that even though they are euthyroid with FT4 treatment total thyroidectomized patients may suffer from hypothyroidism signs and symptoms and metabolic deterioration may occur in such patients. We recommend that we should aim not only to normalize s-TSH levels but also to normalize patients' metabolic parameters and improve the quality of daily life when regulating our treatments.en_US
dc.identifier.doi10.30621/jbachs.916680
dc.identifier.endpage109en_US
dc.identifier.issn2458-8938
dc.identifier.issn2564-7288
dc.identifier.issue2en_US
dc.identifier.startpage104en_US
dc.identifier.urihttps://doi.org/10.30621/jbachs.916680
dc.identifier.urihttps://hdl.handle.net/20.500.14034/68
dc.identifier.volume5en_US
dc.identifier.wosWOS:000701809600013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDokuz Eylul Univ Inst Health Sciencesen_US
dc.relation.journalJournal Of Basic And Clinical Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectthyroid hormone replacementen_US
dc.subjectL-thyroxineen_US
dc.subjecteuthyroidismen_US
dc.subjectmetabolismen_US
dc.subjectTriiodothyronine Levelsen_US
dc.subjectSerum Thyroxineen_US
dc.subjectHypothyroidismen_US
dc.titleThyroid hormone replacement in total thyroidectomized patients: Symptomatic and metabolic effects of levothyroxine monotherapyen_US
dc.typeArticleen_US

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