Comparison of the effects of recombinant human epidermal growth factor (rhEGF) and alendronate sodium on tibial fracture healing in rats: an experimental study

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dc.authoridAhmadov, Asim/0000-0002-9534-3131
dc.authoridTepedelenlioglu, Huseyin Emre/0000-0002-3946-8554
dc.contributor.authorTepedelenlioglu, Huseyin Emre
dc.contributor.authorAbduelaliyev, Ferid
dc.contributor.authorAhmadov, Asim
dc.contributor.authorDizakar, Saadet Ozen Akarca
dc.contributor.authorOzogul, Candan
dc.contributor.authorEsen, Erdinc
dc.date.accessioned2025-03-20T09:50:36Z
dc.date.available2025-03-20T09:50:36Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractPurpose:The objective of this study is to compare the effects of recombinant human epidermal growth factor (rhEGF) on bone healing with those of alendronate, a bisphosphonate widely used in practice.Materials and Methods:An iatrogenic fracture was created in the tibial shaft of 24 Sprague-Dawley rats with osteotome and fixed with an intramedullary Kirschner wire (K-wire). After surgery, Group 1 was given 0.2 mg/kg/day of oral alendronate sodium on postoperative Day 1 to 28, Group 2 received a single dose of 0.5 mg/kg of intraosseous rhEGF on postoperative Days 1 and 14, and Group 3 was followed for a total of four weeks with oral saline. At the end of Week 4, the animals were euthanized and the lower extremities were removed by stripping the soft tissues without damaging the callus. Tissue samples of groups were prepared and and stained with hematoxylin-eosin. After staining, histological scoring was performed to evaluate the degree of union.Results: Alendronate sodium group demonstrated a mean histological score of 6.95 +/- 1.28. The rhEGF group had a lower mean score of 4.85 +/- 1.66. The placebo group exhibited the least progress in bone healing with a mean score of 4.10 +/- 1.68. The histological score was significantly higher in the alendronate sodium group compared to both the rhEGF and placebo groups. There was also a statistically significant difference between the rhEGF and placebo groups in terms of scores. Conclusion: Alendronate sodium enhanced fracture healing processes in rats. The role of rhEGF in bone healing requires further exploration. As the understanding of bisphosphonates and growth factors in bone healing evolves, the strategies for optimizing patient care in orthopedic settings are expected to be developed.
dc.identifier.doi10.17826/cumj.1490881
dc.identifier.endpage711
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue3
dc.identifier.scopusqualityN/A
dc.identifier.startpage703
dc.identifier.trdizinid1267249
dc.identifier.urihttps://doi.org/10.17826/cumj.1490881
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1267249
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2268
dc.identifier.volume49
dc.identifier.wosWOS:001343074300009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjectBisphosphanate
dc.subjectrhEGF
dc.subjectfracture
dc.subjectnonunion
dc.subjectbone healing
dc.titleComparison of the effects of recombinant human epidermal growth factor (rhEGF) and alendronate sodium on tibial fracture healing in rats: an experimental study
dc.typeArticle

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