Electroconvulsive therapy and extracellular matrix glycoproteins in patients with depressive episodes

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dc.authoridAtagun, Murat Ilhan / 0000-0002-8514-0576
dc.authorwosidAtagun, Murat Ilhan/ABA-6588-2021
dc.authorwosidBahceci, Bulent/AAZ-7677-2021
dc.contributor.authorCanbek, Özge Atay
dc.contributor.authorAtagün, Murat İlhan
dc.contributor.authorBalaban, Özlem Devrim
dc.contributor.authorİpekcioğlu, Derya
dc.contributor.authorAlpugan, Barış
dc.contributor.authorYalçın, Suat
dc.contributor.authorErel, Özcan
dc.date.accessioned2022-02-15T16:57:27Z
dc.date.available2022-02-15T16:57:27Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractBackground: The brain extracellular matrix (ECM) is composed of glycoproteins deriving from the cell membrane and joining into nets called perineuronal nets (PNNs). The ECM glycoproteins limit neuroplasticity, cell proliferation, and differentiation. Electroconvulsive therapy (ECT) is provided by electrical currents that may alter several cascades and biophysical effects. ECM conformation might be influenced by the effects of ECT. Methods: Patients with depressive disorders (n = 23) and healthy control subjects (n = 21) were enrolled. Serum levels of the ECM glycoproteins versican, brevican, neurocan, phosphocan and tenascin C were measured with enzyme-linked immunosorbent assay. Serum samples were collected from the patients in the patient group at 3 time points: before ECT, 30 min after the first session, and 30 min after the seventh session. Results: There was a significant difference in tenascin C levels (P = .001) between the groups. No other significant difference was observed. Serum levels of the measured ECM glycoproteins and prolidase activity did not differ in the depression group after the administration of ECT. Conclusions: Our results did not support the claim suggesting a possible mechanism for modulation of ECM glycoproteins by ECT. Serum levels may not necessarily reflect conformational changes in the ECM. Further studies are needed to investigate the effects of ECT on ECM glycoproteins. Modulation of the ECM may provide a new window suggesting improvement in treatments.en_US
dc.identifier.doi10.5152/pcp.2021.20161
dc.identifier.endpage164en_US
dc.identifier.issn2475-0573
dc.identifier.issn2475-0581
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85126009807en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage157en_US
dc.identifier.trdizinid1179139
dc.identifier.urihttps://doi.org/10.5152/pcp.2021.20161
dc.identifier.urihttps://hdl.handle.net/20.500.14034/166
dc.identifier.volume31en_US
dc.identifier.wosWOS:000670758400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.journalPsychiatry And Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElectroconvulsive therapyen_US
dc.subjectextracellular matrixen_US
dc.subjectlecticansen_US
dc.subjectChondroitin Sulfate Proteoglycansen_US
dc.subjectProlidase Activityen_US
dc.subjectPerineuronal Netsen_US
dc.subjectProlineen_US
dc.subjectProteinen_US
dc.subjectStressen_US
dc.subjectMetabolismen_US
dc.subjectSubstrateen_US
dc.subjectSystemen_US
dc.subjectCortexen_US
dc.titleElectroconvulsive therapy and extracellular matrix glycoproteins in patients with depressive episodesen_US
dc.typeArticleen_US

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