The prognostic relationship of 18F-FDG PET/CT metabolic and volumetric parameters in metastatic ALK plus NSCLC

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dc.authorwosidAgüloğlu, Nurşin/HPB-8618-2023
dc.contributor.authorAgüloğlu, Nurşin
dc.contributor.authorAksu, Ayşegül
dc.contributor.authorUnat, Damla S.
dc.contributor.authorAkyol, Murat
dc.date.accessioned2023-03-22T19:47:39Z
dc.date.available2023-03-22T19:47:39Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractObjectiveThe aim of this study is to determine the role of metabolic and volumetric parameters obtained from 18Fluorine-Fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) imaging on progression-free survival (PFS) and overall survival (OS) in patients with advanced nonsquamous cell lung carcinoma (NSCLC) with anaplastic lymphoma kinase (ALK) rearrangement.MethodsPre and post-treatment PET/CT images of the ALK + NSCLC patients between January 2015 and July 2020 were evaluated. The highest standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values were obtained from pre-tyrosine kinase inhibitor (TKI) basal PET/CT (PETpre) and post-TKI PET/CT (PETpost) images. Total MTV (tMTV) and total TLG (tTLG) values were calculated by summing MTV and TLG values in all tumor foci. The change (Delta) in pSUVmax, pMTV, pTLG, tMTV and tTLG before and after treatment was calculated.The relationship of these parameters with OS and PFS was analyzed.ResultstTLG(pre), tMTV(pre), pTLG(pre), pMTV(pre), increment SUVmax, increment tMTV and increment tTLG values were found to be associated with OS; increment tMTV, increment tTLG, tTLG(pre), tMTV(pre), pTLG(pre) and pMTV(pre) were associated with PFS. The cutoff values in both predicting OS and PFS were calculated as -31.6 and 391.1 for increment tMTV and tTLG(pre), respectively. In Cox regression analysis, increment tMTV and stage for OS and increment tMTV and tTLGpre for PFS were obtained as prognostic factors.ConclusionsMetabolic and volumetric parameters, especially TLG values in the whole body before treatment and change in whole body MTV value, obtained from PET/CT may be useful in predicting prognosis and determining treatment strategies for patients with advanced ALK + NSCLC.en_US
dc.identifier.doi10.1097/MNM.0000000000001625
dc.identifier.endpage1224en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85141894637en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1217en_US
dc.identifier.urihttps://doi.org/10.1097/MNM.0000000000001625
dc.identifier.urihttps://hdl.handle.net/20.500.14034/811
dc.identifier.volume43en_US
dc.identifier.wosWOS:000883712700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.journalNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject18F-FDG PETen_US
dc.subjectCTen_US
dc.subjectALK rearrangementen_US
dc.subjectNSCLCen_US
dc.subjectCell Lung-Canceren_US
dc.subjectF-18-Fdg Pet/Cten_US
dc.subjectFdg Pet/Cten_US
dc.subjectSurvivalen_US
dc.subjectTherapyen_US
dc.subjectAdenocarcinomaen_US
dc.subjectCten_US
dc.titleThe prognostic relationship of 18F-FDG PET/CT metabolic and volumetric parameters in metastatic ALK plus NSCLCen_US
dc.typeArticleen_US

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