The Effectiveness of Rectal Suction Biopsy in the Diagnosis of Hirschsprung's Disease

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dc.authoridKoyluoglu, Gokhan/0000-0002-1140-169X
dc.authoridDiniz, Gulden/0000-0003-1512-7584;
dc.authorwosidKoyluoglu, Gokhan/JVZ-3500-2024
dc.authorwosidDiniz, Gulden/HKM-3640-2023
dc.authorwosidÖztan, Mustafa Onur/JLL-2692-2023
dc.contributor.authorBilir, Cemal
dc.contributor.authorOztan, Mustafa Onur
dc.contributor.authorDiniz, Gulden
dc.contributor.authorOzdemir, Tunc
dc.contributor.authorSayan, Ali
dc.contributor.authorKoyluoglu, Gokhan
dc.date.accessioned2024-03-09T18:48:48Z
dc.date.available2024-03-09T18:48:48Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractObjective: In order to analyse the adequacy, sensitivity, and specificity of samples obtained with rectal suction biopsy (RSB) as the standard histopathological diagnostic method in patients with suspected Hirschsprung's disease (HD).Method: This study was carried out between November 2016 and March 2018 with 24 suspected HD patients aged 0-3 years. After calculating rectosigmoid indexes (RSIs) according to barium enema images obtained in contrast -enhanced colon graphies, patients with RSI <1 underwent RSB. Clinical features of patients, treatment options, complications, laboratory test results and radiological findings were recorded for further analyses. An expert pathologist evaluated biopsy specimens, and observations were recorded.Results: There were no ganglion cells in RSB specimens in 10 (41. 6%) patients who received the diagnosis of HD later on. Ganglion cells were detected in specimens of 5 (20. 8%) patients; thus, the diagnosis of HD was excluded. Inadequate or suspicious biopsy specimens for histopathological evaluation were observed in 9 (37. 5%) patients. If the biopsy specimen volume was more voluminous than 4 mm3, its diagnostic sensitivity and specificity for HD were 80% and 66.67%, respectively (area under the curve=0.789); If the submucosa/mucosa ratio was greater than 0.75 or the submucosa/total specimen ratio was greater than 0.42, then the diagnostic sensitivity and the specificity of the specimen for HD were 86.67% and 66.67%, respectively.Conclusion: In this prospective cross-sectional study, we demonstrated that RSB in diagnosing HD is a feasible, safe method with high sensitivity and specificity and low complication rates.en_US
dc.identifier.doi10.4274/buchd.galenos.2023.03789
dc.identifier.endpage115en_US
dc.identifier.issn2822-4469
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage108en_US
dc.identifier.trdizinid1251637
dc.identifier.urihttps://doi.org/10.4274/buchd.galenos.2023.03789
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1489
dc.identifier.volume13en_US
dc.identifier.wosWOS:001049222400005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal of Dr Behcet Uz Childrens Hospitalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHirschsprung's Disease; Ganglion; Rectal Aspiration Biopsy; Rectal Biopsyen_US
dc.titleThe Effectiveness of Rectal Suction Biopsy in the Diagnosis of Hirschsprung's Diseaseen_US
dc.typeArticleen_US

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