Cytotoxic effects of silver nanoparticles synthesized using Asphodelus aestivus Brot. aqueous extract

Basit Öğe Kaydı
dc.authoridYILMAZ SUSLUER, SUNDE/0000-0002-0535-150X
dc.authoridGunduz, Cumhur/0000-0002-6593-3237
dc.authoridTastan, Pelin/0000-0003-0913-5369;
dc.authorwosidYILMAZ SUSLUER, SUNDE/HJZ-2716-2023
dc.authorwosidGunduz, Cumhur/C-1243-2014
dc.authorwosidTastan, Pelin/JTU-8714-2023
dc.authorwosidErdogan, Tuğçe Fafal/ACM-6019-2022
dc.contributor.authorTastan, Pelin
dc.contributor.authorFafal, Tugce
dc.contributor.authorTuezuen, Burcu Suemer
dc.contributor.authorOzmen Yelken, Besra
dc.contributor.authorKayabasi, Cagla
dc.contributor.authorYilmaz Susluer, Sunde
dc.contributor.authorGunduz, Cumhur
dc.date.accessioned2024-03-09T18:48:44Z
dc.date.available2024-03-09T18:48:44Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractThe aim of the study is to examine the cytotoxic, apoptotic effects and gene expressions of Asphodelus aestivus water extract (ASP) and silver nanoparticles (AgNPS) on decided cancer lines. Breast cancer cell lines MCF-7 and MDA-231; melanoma cancer lines MEWO and CHL-1; fibroblast cancer lines WI-38 and HEL 299 were selected for biological activities. xCELLigence system was used for cytotoxicity. Annexin V-EG FP Apoptosis detection kit was used for apoptosis and gene expressions were assessed by real time online RT-PCR by using cancer cell lines Qiagen kits. AgNPS showed significant cytotoxicity in all cell lines. The most prominent apoptosis was determined in MCF-7 cell line for AgNPS. It has been observed that the most important progress in gene expression, the suppression capacity of MUC1-C, a breast cancer-associated oncoprotein, is greatly increased by nanoparticle formation. In addition, cells that were not affected at all in MDA-MB-231 breast cancer oncoprotein started to suppress with nanoparticles. In conclusion, it was determined that silver nanoparticles increased the effect especially in breast cancer cell lines and could be considered for use.en_US
dc.description.sponsorshipTUBITAK [SBAG-114S730]; FABAL (Ege University, Faculty of Pharmacy Pharmaceutical Sciences Research Centre); Izmir Institute of Technology, Center for Materials Researchen_US
dc.description.sponsorshipThis research was supported by TUBITAK (project number SBAG-114S730) . We are thankful to FABAL (Ege University, Faculty of Pharmacy Pharmaceutical Sciences Research Centre) and Izmir Institute of Technology, Center for Materials Research.en_US
dc.identifier.doi10.29228/jrp.413
dc.identifier.endpage1251en_US
dc.identifier.issn2630-6344
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85161585377en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1242en_US
dc.identifier.trdizinid1179514en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.413
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1179514
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1451
dc.identifier.volume27en_US
dc.identifier.wosWOS:001011434600021en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal of Research In Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGreen Synthesis; Apoptosis; Cancer; Melanoma; Cancer Cell Lines; Silver Nanoparticlesen_US
dc.titleCytotoxic effects of silver nanoparticles synthesized using Asphodelus aestivus Brot. aqueous extracten_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
1451.pdf
Boyut:
662.19 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu