Evaluation of MicroRNAs in Pediatric Epilepsy

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dc.authoridTekin, Hande/0000-0002-4407-164X
dc.authoridKaplan, Emre/0000-0002-8314-635X
dc.authorwosidTekin, Hande/AAA-8892-2021
dc.authorwosidKaplan, Emre/JCE-7888-2023
dc.contributor.authorCarman, Kursat Bora
dc.contributor.authorTekin, Hande Gazeteci
dc.contributor.authorCavusoglu, Dilek
dc.contributor.authorYarar, Coskun
dc.contributor.authorKaplan, Emre
dc.contributor.authorKarademir, Cefa Nil
dc.contributor.authorArslantas, Didem
dc.date.accessioned2024-03-09T18:48:50Z
dc.date.available2024-03-09T18:48:50Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractObjective: The pathophysiology of epilepsy remains unknown. Recent research has shown that microRNA expression changes in epileptic adults. In the present work, we aimed to identify serum microRNA expression in drug-responsive and resistant children with idiopathic generalized epilepsy.Materials and Methods: The study included 43 (20 male and 23 female) epilepsy patients and 66 (43 male and 23 female) control subjects. The mean ages of the groups were 113.41 & PLUSMN; 61.83 and 105.46 & PLUSMN; 62.31 months, respectively. Twenty-eight epileptic patients were classified as drug resistant. Thirteen of the controls were the siblings of patients with epilepsy. The study only included children with idiopathic generalized epilepsy who had normal brain magnetic resonance imaging. The serum microRNA expressions (microRNA-181a, microRNA-155, microRNA-146, and microRNA-223) were investigated. Expressions of serum microRNA-181a, microRNA-155, microRNA-146, and microRNA-223 were previously investigated in epilepsy patients and children with febrile seizures. Therefore, these microRNAs were chosen. The expressions of serum levels of microRNAs were determined using quantitative real-time polymerase chain reaction.Results: The results indicated that the expressions of serum microRNA-155 and microRNA-223 were elevated in epileptic children (P < .05). The expression of the same microRNAs was also elevated in individuals with drug-resistant epilepsy compared to healthy controls (P < .05). microRNA-146a, microRNA-155, and microRNA-223 expressions were higher in drug-resistant patients than in drug-responsive children (P < .05). A logistic regression study determined that an increase of microRNA-155 was a risk for epilepsy, while a decrease of microRNA-146a risk for epilepsy.Conclusion: Few researchers have investigated the function of microRNAs in the development of childhood epilepsy. Our findings revealed that epilepsy patients have abnormal microRNAexpression.en_US
dc.identifier.doi10.5152/TurkArchPediatr.2023.22320
dc.identifier.issn2757-6256
dc.identifier.issue4en_US
dc.identifier.pmid37357458en_US
dc.identifier.scopus2-s2.0-85163690896en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.trdizinid1187765en_US
dc.identifier.urihttps://doi.org/10.5152/TurkArchPediatr.2023.22320
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1187765
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1503
dc.identifier.volume58en_US
dc.identifier.wosWOS:001027589600014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Archives of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpilepsy; Microrna; Drug Resistant; Childrenen_US
dc.titleEvaluation of MicroRNAs in Pediatric Epilepsyen_US
dc.typeArticleen_US

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