Serum nitric oxide levels are depleted in depressed patients treated with electroconvulsive therapy

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dc.authoridAtagün, Murat İlhan/0000-0002-8514-0576
dc.authoridIpekcioglu, Derya/0000-0001-6143-5671
dc.authoridEREL, Ozcan/0000-0002-2996-3236
dc.authoridŞenat, Almila/0000-0002-5806-562X
dc.authorwosidAtagün, Murat İlhan/ABA-6588-2021
dc.authorwosidAtay, özge/JDW-2065-2023
dc.authorwosidBalaban, Özlem Devrim/HGT-8219-2022
dc.authorwosidİpekçioğlu, Derya/HJA-0297-2022
dc.authorwosidErel, özcan/U-1008-2019
dc.authorwosidŞenat, Almila/ACJ-4022-2022
dc.contributor.authorAtagün, Murat İlhan
dc.contributor.authorAtay, Özge Canbek
dc.contributor.authorBalaban, Özlem D.
dc.contributor.authorİpekçioğlu, Derya
dc.contributor.authorAlpugan, Barış
dc.contributor.authorYalçın, Suat
dc.contributor.authorSenat, Almila
dc.date.accessioned2024-03-09T18:48:57Z
dc.date.available2024-03-09T18:48:57Z
dc.date.issued2021
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractBackground: Nitric oxide (NO) is an endogenous substance which has several endocrine functions and may act as neurotransmitter in the brain. High levels of NO may provoke nitrosative stress. Aim: It was aimed to examine serum levels of NO in patients with depressive episodes who were treated with electroconvulsive therapy (ECT) in this study. Methods: The design was a case-control, follow-up study. Patients with depressive episodes (n = 23) and a healthy control group (n = 21) were enrolled. Three serum samples were obtained from the patient group (before ECT, after first and seventh sessions). NO, nitrite, and nitrate levels were examined. Statistical Analysis: Differences between groups were examined with t-test or Mann-Whitney U-test. Longitudinal data were evaluated with Panel Regression Analysis and Kruskal-Wallis Test. Results: Serum levels of NO and nitrite decreased significantly after the seventh session of ECT administration compared to the baseline and first session. Nitrate levels did not differ between the assessments. Conclusions: Reduction of the serum NO and nitrite levels might be a contributing factor for hypertension during the sessions. These findings are reflect the circulating NO levels. Further studies may dissect NO physiology in the brain in mental disorders and potential external effects.en_US
dc.identifier.endpage461en_US
dc.identifier.issn0019-5545
dc.identifier.issn1998-3794
dc.identifier.issue5en_US
dc.identifier.pmid34789933en_US
dc.identifier.scopus2-s2.0-85117939275en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage456en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1533
dc.identifier.volume63en_US
dc.identifier.wosWOS:000753683300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDepressive Disorder; Electroconvulsive Therapy; Nitric Oxideen_US
dc.titleSerum nitric oxide levels are depleted in depressed patients treated with electroconvulsive therapyen_US
dc.typeArticleen_US

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