Cut-off values of 6-min walk test and sit-to-stand test for determining symptom burden in atrial fibrillation

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dc.authoridGurses, H. Nilgun/0000-0002-5846-6781
dc.authoridzeren, Melih/0000-0002-9749-315X
dc.authorwosidGurses, H. Nilgun/AAD-3070-2020
dc.authorwosidzeren, Melih/HNR-7817-2023
dc.contributor.authorZeren, Melih
dc.contributor.authorKarcı, Makbule
dc.contributor.authorDemir, Rengin
dc.contributor.authorGürses, Hülya Nilgün
dc.contributor.authorOktay, Veysel
dc.contributor.authorUzunhasan, Işıl
dc.contributor.authorYiğit, Zerrin
dc.date.accessioned2023-03-22T19:47:24Z
dc.date.available2023-03-22T19:47:24Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractBackground Since symptomatology is a major predictor of quality of life and an endpoint for the management of atrial fibrillation (AF), practical approaches for objectively interpreting symptom burden and functional impairment are needed. Aims We aimed to provide cut-off values for two frequently used field tests to be able to objectively interpret symptom burden in atrial fibrillation. Methods One hundred twenty-five patients with AF were evaluated with European Heart Rhythm Association (EHRA) score, 6-min walk test (6MWT), 30 s sit-to-stand test (30 s-STST), Short-Form 36 (SF-36), International Physical Activity Questionnaire-Short Form (IPAQ-SF), and spirometry. Patients with EHRA 1 were classified as asymptomatic, and those with EHRA 2-4 as symptomatic. Cut-off values of 6MWT and 30 s-STST for discriminating between these patients were calculated. Results The optimal cut-off value was 450 m for 6MWT (sensitivity: 0.71; specificity of 0.79) and 11 repetitions for 30 s-STST (sensitivity 0.77; specificity of 0.70). Area under ROC curve was 0.75 for both tests (p < 0.001). Discriminative properties of the two tests were similar, and they were significantly correlated (r = 0.58; p < 0.001). Subgroup analysis revealed patients below cut-off values also had worse outcomes in SF-36, IPAQ-SF, and spirometry. Conclusions In patients with AF, walking < 450 m in 6MWT or performing < 11 repetitions in 30 s-STST indicates increased symptom burden, as well as impaired exercise capacity, quality of life, physical activity participation, and pulmonary function. These cut-off values may help identifying patients who may require adjustments in their routine treatment or who may benefit from additional rehabilitative approaches.en_US
dc.identifier.doi10.1007/s11845-021-02901-y
dc.identifier.endpage2595en_US
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue6en_US
dc.identifier.pmid35066793en_US
dc.identifier.scopus2-s2.0-85123471428en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2587en_US
dc.identifier.urihttps://doi.org/10.1007/s11845-021-02901-y
dc.identifier.urihttps://hdl.handle.net/20.500.14034/679
dc.identifier.volume191en_US
dc.identifier.wosWOS:000745549100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.journalIrish Journal Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtrial fibrillationen_US
dc.subjectEHRA scoreen_US
dc.subjectFunctional impairmenten_US
dc.subjectReference valueen_US
dc.subjectSit-to-stand testen_US
dc.subjectSix-minute walk testen_US
dc.subjectSymptomatologyen_US
dc.subjectQuality-Of-Lifeen_US
dc.subjectFunctional-Capacityen_US
dc.subjectPhysical-Activityen_US
dc.subjectDistanceen_US
dc.subjectFitnessen_US
dc.subjectValidationen_US
dc.subjectPredictoren_US
dc.subjectShuttleen_US
dc.titleCut-off values of 6-min walk test and sit-to-stand test for determining symptom burden in atrial fibrillationen_US
dc.typeArticleen_US

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