Investigation of dynamic hyperinflation and its relationship with exercise capacity in children with bronchiectasis

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dc.authoridzeren, Melih/0000-0002-9749-315X
dc.authorwosidzeren, Melih/HNR-7817-2023
dc.contributor.authorTosun, Beyza Nur Caglar
dc.contributor.authorZeren, Melih
dc.contributor.authorBarlık, Meral
dc.contributor.authorDemir, Esen
dc.contributor.authorGülen, Figen
dc.date.accessioned2023-03-22T19:47:29Z
dc.date.available2023-03-22T19:47:29Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractBackground and Aim Dynamic hyperinflation (DH) is a major contributor to exercise intolerance in patients with obstructive lung diseases. However, it has not been investigated in children with bronchiectasis (BE). We aimed to investigate dynamic ventilatory responses and their influence on functional exercise capacity in children with BE. Methods Forty children with BE (mean forced expiratory volume in 1 s [FEV1] = 78 +/- 19%pred) were included. Six-minute walk test (6MWT) was conducted using Spiropalm 6MWT (R) for evaluating dynamic ventilatory responses including inspiratory capacity (IC), minute ventilation (VE), breathing reserve (BR) and respiratory rate (RR). A decrease of >= 100 ml in IC during exertion was defined as DH. Also, spirometry was performed, and peripheral muscle strength were measured. Results Twenty patients (50%) developed DH, and four patients (10%) were ventilatory limited (BR < %30) during 6MWT. There was a 176 [100-590] ml decrease in IC after exertion in patients with DH. DH did not correlate to clinical or functional indicators of the disease, except for an increase in RR ( increment RR) during exertion. High increment RR was associated with presence of DH (r(pb)= 0.390; p < 0.05). Clinical features, peripheral muscle strength, and Spiropalm 6MWT metrics including 6MWT distance did not differ between patients with and without DH. Univariate analysis revealed FVC% (R = 0.340), VEpeak (R = 0.565), quadriceps strength (R = 0.698) and handgrip strength (R = 0.711) were the only predictors of 6MWT distance (p < 0.05). Conclusion Although DH is common in children with BE, the severity of DH is rather low and may not seem to affect functional exercise capacity. However, peripheral muscle strength was a major contributor to functional exercise capacity.en_US
dc.identifier.doi10.1002/ppul.26028
dc.identifier.endpage2226en_US
dc.identifier.issn8755-6863
dc.identifier.issn1099-0496
dc.identifier.issue9en_US
dc.identifier.pmid35666051en_US
dc.identifier.scopus2-s2.0-85131758971en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2218en_US
dc.identifier.urihttps://doi.org/10.1002/ppul.26028
dc.identifier.urihttps://hdl.handle.net/20.500.14034/734
dc.identifier.volume57en_US
dc.identifier.wosWOS:000810559800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalPediatric Pulmonologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbreathing reserveen_US
dc.subjectbronchiectasisen_US
dc.subjectdynamic hyperinflationen_US
dc.subjectfunctional exercise capacityen_US
dc.subjectlung functionen_US
dc.subjectReference Valuesen_US
dc.subjectCystic-Fibrosisen_US
dc.subjectFlow Limitationen_US
dc.subjectGrip Strengthen_US
dc.subjectLung-Functionen_US
dc.subjectWalk Testen_US
dc.subjectPulmonaryen_US
dc.subjectDeterminantsen_US
dc.subjectStatementen_US
dc.subjectDyspneaen_US
dc.titleInvestigation of dynamic hyperinflation and its relationship with exercise capacity in children with bronchiectasisen_US
dc.typeArticleen_US

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