Insights from CD71 presentation and serum lipid peroxidation in myasthenia gravis - A small cohort study

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dc.authoridDai, Ayse Suna/0009-0003-7690-8322
dc.authoridTuncer Caglayan, Sinem/0000-0002-8947-8646
dc.authoridElibol, Birsen/0000-0002-9462-0862
dc.contributor.authorCaglayan, Sinem Tuncer
dc.contributor.authorElibol, Birsen
dc.contributor.authorSevercan, Feride
dc.contributor.authorGursoy, Esra Basar
dc.contributor.authorTiftikçioğlu, Bedile İrem
dc.contributor.authorDalar, Zeynep Gungordu
dc.contributor.authorCelik, Ceren
dc.date.accessioned2025-03-20T09:51:09Z
dc.date.available2025-03-20T09:51:09Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractMyasthenia gravis (MG) is a multifaceted autoimmune disorder affecting the postsynaptic neuromuscular junction. In this study, we examined CD4+ and CD8+ T lymphocyte levels and ratios within peripheral blood mononuclear cells (PBMCs) in MG patients. Additionally, we assessed lymphocytes for the expression of CD71, which functions as a transferrin receptor mediating the uptake of iron into the cells. Building on recent discussions regarding CD20 depletion treatments in MG, we also scrutinized lymphocytes for CD20 expression. Comparative analyses were conducted among healthy controls, newly diagnosed MG patients, those undergoing pyridostigmine treatment alone, and MG patients receiving combination therapies. In the patients, the ratio of CD3+CD4+ T lymphocytes to CD3+ T lymphocytes was found to be decreased compared to the healthy controls, while the ratio of CD3+CD8+ cells to CD3+CD4+ cells increased. An increase in the percentage of CD71expressing lymphocytes was observed in MG patients compared to the healthy control group, while CD20+ lymphocytes exhibited no statistical changes. Moreover, heightened serum lipid peroxidation levels were found in MG patients. These results suggest a possible relationship between iron metabolism, levels of CD71-expressing cells, and lipid peroxidation in MG. Conversely, pyridostigmine treatment reduced the levels of CD71-expressing cells and lipid peroxidation, suggesting potential immunomodulatory and antioxidant impacts of pyridostigmine in MG, either directly or indirectly.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) ARDEB [1003, 218S986, 218S987, 218S988]
dc.description.sponsorshipThis study was funded by the Scientific and Technological Research Council of Turkey (TUBITAK) ARDEB 1003, Grant no: 218S986, 218S987, and 218S988. We acknowledge Dr. Aydan Dag (Bezmialem Vak & imath;f University, Istanbul, Turkey) for the flow cytometry facility. The authors also thank Dr. Cumhur Guenduez (Ege University, Izmir, Turkey) and Ceyda Ozen for their support.
dc.identifier.doi10.1016/j.intimp.2024.112787
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.pmid39088914
dc.identifier.scopus2-s2.0-85200111354
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2024.112787
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2447
dc.identifier.volume140
dc.identifier.wosWOS:001285947100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Immunopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectMyasthenia gravis
dc.subjectPyridostigmine
dc.subjectCD71
dc.subjectLipid peroxidation
dc.subjectIron
dc.subjectFerroptosis
dc.titleInsights from CD71 presentation and serum lipid peroxidation in myasthenia gravis - A small cohort study
dc.typeArticle

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