Impact of magnetic resonance on the decision of conservative surgery in advanced larynx cancer

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dc.authoridAdıbelli, Zehra Hilal / 0000-0001-9265-8114
dc.authoridMuderris, Togay / 0000-0003-4014-8176
dc.authoridKoç, Ali Murat / 0000-0001-6824-4990
dc.authorscopusid57189621224
dc.authorscopusid26662535000
dc.authorscopusid57217154014
dc.authorscopusid6504495599
dc.authorscopusid57195995759
dc.authorscopusid8347658300
dc.authorwosidAdıbelli, Zehra Hilal/ABE-8234-2020
dc.authorwosidKoç, Ali Murat/ABC-5838-2020
dc.authorwosidMuderris, Togay/AAS-5874-2020
dc.contributor.authorTokat, Taşkın
dc.contributor.authorAdıbelli, Zehra Hilal
dc.contributor.authorKoç, Ali Murat
dc.contributor.authorMüderris, Togay
dc.contributor.authorAtsal, Görkem
dc.contributor.authorÖzkök, Güliz
dc.date.accessioned2022-02-15T16:58:40Z
dc.date.available2022-02-15T16:58:40Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractObjective: To evaluate the utility of magnetic resonance images (MRI) in the selection of treatment procedures for intermediate-advanced laryngeal cancers. Material and method: This study included patients with histologically proven laryngeal squamous cell carcinoma defined as cT3 and T4a at our tertiary academic care hospital. All scans were evaluated by two radiologists experienced in head and neck cross-sectional studies. Signal patterns in MRI sections of laryngeal compartment subsites were delineated as T1 w, T2w hyperintensity, and T2w intermediate signals, and were compared with the postoperative pathological results. Sensitivity, specificity, positive predictive values (PPV), and negative predictive values (NPV) were calculated. Results: The study included 51 patients with a mean age of 62.55 +/- 9.14 (range, 45-80) years. Tumor was glottic in 12 (23.5%) patients, supraglottic in 19 (31.4%) patients, glottic-supraglottic in 11 (21.6%) patients, transglottic in 9 (27%) patients. The posterior paraglottic space had the strongest specificity of MRI according to tumor infiltration in the histologic analysis (specificity 96.9% and sensitivity 78.6%). The specificity of MRI was poor for tumor infiltration in thyroid cartilage (specificity 70.0%). Spearman's test demonstrated that there was a statistically significant correlation between the MRI-based prediction scores of all subunites and the findings of histopathologic analyses (mean +/- SD: 4.96 +/- 4.46-5.53 +/- 4.38, respectively, R-2: 0.711, p<0.001). Conclusion: The high specificity values of the predictions, which were MRI-based in all subsites, indicated that MRI could provide an important contribution for defining tumor infiltration and the presurgical assessment of patients with tumors of the larynx.en_US
dc.identifier.doi10.1016/j.amjoto.2020.102855
dc.identifier.issn0196-0709
dc.identifier.issn1532-818X
dc.identifier.issue2en_US
dc.identifier.pmid33445039en_US
dc.identifier.scopus2-s2.0-85099124342en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjoto.2020.102855
dc.identifier.urihttps://hdl.handle.net/20.500.14034/448
dc.identifier.volume42en_US
dc.identifier.wosWOS:000621603000024en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.journalAmerican Journal Of Otolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLaryngeal canceren_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectConservative laryngeal surgeryen_US
dc.subjectSupracricoid partial laryngectomyen_US
dc.subjectOpen partial horizontal laryngectomyen_US
dc.titleImpact of magnetic resonance on the decision of conservative surgery in advanced larynx canceren_US
dc.typeArticleen_US

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