Erianin, a promising agent in the treatment of glioblastoma multiforme triggers apoptosis in U373 and A172 glioblastoma cells

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dc.authoridSerter Koçoğlu, Sema/0000-0002-3180-4007
dc.authorwosidSerter Koçoğlu, Sema/ABQ-8779-2022
dc.contributor.authorKocoglu, Sema Serter
dc.contributor.authorSecme, Mucahit
dc.contributor.authorElmas, Levent
dc.date.accessioned2023-03-22T19:47:26Z
dc.date.available2023-03-22T19:47:26Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractGlioblastoma is an aggressive, common and deadly primary intracranial brain tumor in adults. The antitumor activity of erianin, a dibenzyl compound found in Dendrobium chrysotoxum Lindl. extract, has not been previously demonstrated in glioblastoma. We investigated the anticancer activity and underlying mechanisms of erianin in human U373 and A172 glioma cells. The effects of erianin on cell viability, apoptosis, migration and invasion were estimated by the XTT test, the reverse transcription-polymerase chain reaction (RT-PCR), annexin V staining assay protocol for apoptosis, wound healing assay, and Matrigel (R) invasion chamber, respectively. The effective amounts of erianin in U373 and A172 cells were 16 and 64 mu M at 48 h, respectively. Erianin also significantly induced apoptosis by inhibiting B-cell lymphoma 2 (Bcl-2), caspase-8, caspase-9 and tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD), and activation of caspase-3 and BH3 interacting domain death agonist (BID) gene expression. In addition, erianin significantly increased the number of apoptotic cells in U373 and A172 cells and significantly decreased invasion and migration in U373 and A172 cells. Taken together, our results suggest that erianin may be a new therapeutic anticancer drug component with a potent apoptotic effect and a potential for treating glioblastoma.en_US
dc.identifier.doi10.2298/ABS220219021S
dc.identifier.endpage234en_US
dc.identifier.issn0354-4664
dc.identifier.issn1821-4339
dc.identifier.issue3en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://doi.org/10.2298/ABS220219021S
dc.identifier.urihttps://hdl.handle.net/20.500.14034/705
dc.identifier.volume74en_US
dc.identifier.wosWOS:000871979000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherInst Bioloska Istrazivanja Sinisa Stankovicen_US
dc.relation.journalArchives Of Biological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectglioblastomaen_US
dc.subjecterianinen_US
dc.subjectapoptosisen_US
dc.subjectanticanceren_US
dc.subjectDendrobium chrysotoxum Lindlen_US
dc.subjectIn-Vitroen_US
dc.subjectGrowthen_US
dc.titleErianin, a promising agent in the treatment of glioblastoma multiforme triggers apoptosis in U373 and A172 glioblastoma cellsen_US
dc.typeArticleen_US

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