Is favipiravir a potential therapeutic agent in the treatment of intervertebral disc degeneration by suppressing autophagy and apoptosis?

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dc.authoridOzbek, hanefi/0000-0002-8084-7855
dc.authoridYILMAZ, Ibrahim/0000-0003-2003-6337
dc.authorwosidOzbek, hanefi/O-3472-2019
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorAkalan, Hande
dc.contributor.authorŞirin, Duygu Yaşar
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorAteş, Özkan
dc.date.accessioned2023-03-22T19:47:30Z
dc.date.available2023-03-22T19:47:30Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractAIM: To evaluate the effects of favipiravir (FVP) on cell viability and cytotoxicity in human degenerated primary intervertebral disc (IVD) tissue cell cultures. Furthermore, the protein expressions of hypoxia-inducible factor 1 alpha (HIF-1 alpha), nuclear factor-kappa-b (NF-kappa B), and interleukin-1 beta (IL-1 beta) were also examined. MATERIAL and METHODS: Untreated cell cultures served as the control group, named group 1. Cell cultures treated with FVP served as the study group, named group 2. Pharmacomolecular analyses were performed in all groups at 0, 24, 48, and 72 hours (h). Obtained data were evaluated statistically. RESULTS: Cell proliferation was suppressed in the FVP-treated samples compared to the control group samples at 24 and 72 h, and this was statistically significant (p<0.05). Decreased or increased protein expression levels of HIF-1 alpha, NF-kappa B, and IL-1 beta in FVP-treated samples may be an indication of suppression in anabolic events as well as proliferation in IVD cultures. FVP administration showed that AF/NP cells in a culture medium may induce a strong inflammatory response to FVP. This strong inflammatory response is likely to cause slowed proliferation. It may also be a trigger for many catabolic events. NF-kappa B expression increased within the first 24 h and then decreased rapidly. Based on the data obtained, it may be suggested that the rapidly increasing NF-kB may have stimulated the expression of many antiproliferative genes. CONCLUSION: The suppression of IL-1 beta and NF-kB protein expressions in IVD cells treated with FVP is important in the treatment of IVD degeneration (IDD). If the protein expression of HIF-1 alpha could be increased along with the suppression of IL-1 beta and NF-kB, FVP would perhaps be a promising pharmacological agent in the treatment of IDD.en_US
dc.identifier.doi10.5137/1019-5149.JTN.38252-22.3
dc.identifier.endpage687en_US
dc.identifier.issn1019-5149
dc.identifier.issue4en_US
dc.identifier.pmid35652184en_US
dc.identifier.scopus2-s2.0-85135031957en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage680en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.38252-22.3
dc.identifier.urihttps://hdl.handle.net/20.500.14034/739
dc.identifier.volume32en_US
dc.identifier.wosWOS:000838824600020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.journalTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFavipiraviren_US
dc.subjectHIF-1 alphaen_US
dc.subjectIL-1 betaen_US
dc.subjectNF-kappa Ben_US
dc.subjectNf-Kappa-Ben_US
dc.subjectNucleus Pulposus Cellsen_US
dc.subjectInflammatory Cytokinesen_US
dc.subjectSignaling Pathwayen_US
dc.subjectHif-1-Alphaen_US
dc.subjectExpressionen_US
dc.subjectOsteoarthritisen_US
dc.subjectInhibitoren_US
dc.subjectCovid-19en_US
dc.subjectHypoxiaen_US
dc.titleIs favipiravir a potential therapeutic agent in the treatment of intervertebral disc degeneration by suppressing autophagy and apoptosis?en_US
dc.typeArticleen_US

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