Efficiency of resveratrol in the prevention and treatment of age-related hearing loss

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dc.contributor.authorMüderris, Togay
dc.contributor.authorSağlam, Atiye
dc.contributor.authorÜnsal, Döndü
dc.contributor.authorMulazimoğlu, Selçuk
dc.contributor.authorSevil, Ergun
dc.contributor.authorKayhan, Handan
dc.date.accessioned2022-02-15T16:58:09Z
dc.date.available2022-02-15T16:58:09Z
dc.date.issued2022
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractAge-related hearing loss (ARHL) is a major public health concern, which is characterized by gradual, progressive sensorineural hearing loss and deterioration of sound localization, with no effective treatment available to date. The aim of the present study was to evaluate the efficacy of resveratrol to prevent and treat ARHL. For this purpose, 32 male C57BL/6 mice were assigned to four groups: Early treatment, late treatment, control and sham control. The experiment lasted for 15 months. Treatment was started at three months of age in the early treatment group and at sixth months in the late treatment group. The auditory brainstem response test was performed once every three months. At the end of the study period, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, NF-kappa B, Bcl-2, Bcl-xL, Bax, Bcl-2 homologous antagonist/killer (Bak), caspase-3 and caspase-9 levels in the cochlear tissues of the animals were analyzed by reverse transcription-quantitative PCR. Hearing thresholds of the mice in the early treatment group were better than those in the other groups (P<0.001) at the end of the study. However, hearing levels in the late treatment group were not significantly different from those in the control groups (P>0.05), although mean thresholds were lower. The threshold shift in the early treatment group was significantly lower at all frequencies when compared with those in the control groups (P<0.001). The mRNA expression levels of pro-apoptotic genes Bax and Bak were lower (P<0.05), anti-apoptotic genes Bcl-2 and Bcl-xL were higher (P<0.05), NF-kappa B, COX-2 and iNOS as genes that have a role in inflammation and caspase-3 and caspase-9 as genes with a vital role in apoptosis were lower (P<0.05) in the early treatment group when compared with the late treatment and control groups. These results suggested that resveratrol is effective in the prevention of ARHL, particularly when started prior to the beginning of hearing loss.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114S938]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (grant no. 114S938).en_US
dc.identifier.doi10.3892/etm.2021.10962
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.issue1en_US
dc.identifier.pmid34849155en_US
dc.identifier.urihttps://doi.org/10.3892/etm.2021.10962
dc.identifier.urihttps://hdl.handle.net/20.500.14034/354
dc.identifier.volume23en_US
dc.identifier.wosWOS:000723192800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpandidos Publ Ltden_US
dc.relation.journalExperimental And Therapeutic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectage-related hearing lossen_US
dc.subjectauditory brainstem responseen_US
dc.subjectresveratrolen_US
dc.subjectoxidative stressen_US
dc.subjectantioxidantsen_US
dc.subjectMitochondrial-Dnaen_US
dc.subjectOxidative Stressen_US
dc.subjectHair-Cellsen_US
dc.subjectAntioxidantsen_US
dc.subjectPolyphenolsen_US
dc.titleEfficiency of resveratrol in the prevention and treatment of age-related hearing lossen_US
dc.typeArticleen_US

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