Antibiotic resistance rates and penicillin MIC distribution in patients with streptococcal pneumonia between 2013-2019, and use of antibiotics in clinical practice

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dc.contributor.authorAnar, Ceyda
dc.contributor.authorBicmen, Can
dc.contributor.authorGuldaval, Filiz
dc.contributor.authorAtay, Tuba
dc.contributor.authorGayaf, Mine
dc.contributor.authorBalci, Gunseli
dc.contributor.authorAlici, Ibrahim Onur
dc.contributor.authorDoğan, Betül İkbal
dc.contributor.authorBüyükşirin, Melih
dc.contributor.authorAyrancı, Aysu
dc.contributor.authorKaradeniz, Gülistan
dc.contributor.authorPolat, Gülru
dc.date.accessioned2023-03-22T19:47:21Z
dc.date.available2023-03-22T19:47:21Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractPurpose: The purpose of the present study is to investigate the antibiotic resistance rates and use of antibiotics in patients with streptococcal pneumonia in a reference tertiary care hospital for pulmonary diseases in Izmir, Turkey.Methods: A total of 1224 cases with streptococcal pneumonia between 2013 and 2019 were included in the study, retrospectively. Drug susceptibility testing for penicillin and other antibiotics were performed according to the recommendations of EUCAST criteria. Clinical data and general characteristics were collected and evaluated for each patient in accordance with the susceptibility testing report.Results: Totally, resistance rates for trimethophrim-sulfamethoxazole, penicillin (oxacillin), erythromycin, tetra-cycline, clindamycin and levofloxacin resistance were 63.5%, 39.8%, 37.7%, 37.6%, 28.8%, and 4.8%, respec-tively. Antibiotic resistance was not detected against vancomycin,teicoplanin and linezolid. Multidrug resistance rate was found to be 27.1%. It was observed that there was a statistically significant decrease in trimethophrim-sulfamethoxazole, penicillin (oxacillin), erythromycin, clindamycin and levofloxacin resistance rates by years (p: 0.000, 0.004, 0.000, 0.001, 0.010, respectively). The penicillin MIC distribution was higher at the range of 0.12-2 mu g/mL and there was statistical difference among the ranges of MIC values for the representative years (p:0.033). Among the antibiotics investigated, the most commonly used antibiotic was moxifloxacin.Conclusions: Trimethophrim-sulfamethoxazole resistance rate has been found higher than other antibiotics. As penicillin MIC values were at the range of 0.12-2 mu g/mL frequently, high doses of penicillin treatment might be required in some patients. It is noteworthy that significant decrease in resistance rates in penicillin, erythromycin, clindamycin and tetracycline could be due to the vaccination programme carried out since 2008 in Turkey. As the empiric use of quinolones is high it would be more appropriate to use it according to the susceptibility testing. It is important to determine the regional antimicrobial susceptibility for Streptococcus pneumoniae to select appropriate empirical antimicrobials in the clinical practice.en_US
dc.identifier.doi10.1016/j.ijmmb.2022.05.012
dc.identifier.endpage581en_US
dc.identifier.issn0255-0857
dc.identifier.issn1998-3646
dc.identifier.issue4en_US
dc.identifier.pmid36028454en_US
dc.identifier.scopus2-s2.0-85136491151en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage577en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijmmb.2022.05.012
dc.identifier.urihttps://hdl.handle.net/20.500.14034/643
dc.identifier.volume40en_US
dc.identifier.wosWOS:000918225100022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.journalIndian Journal Of Medical Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibiotic susceptibility testen_US
dc.subjectAntibioticsen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectCommunity-Acquired Pneumoniaen_US
dc.subjectAntimicrobial Susceptibilityen_US
dc.subjectMacrolide Resistanceen_US
dc.subjectRisk-Factorsen_US
dc.subjectAdultsen_US
dc.subjectAzithromycinen_US
dc.titleAntibiotic resistance rates and penicillin MIC distribution in patients with streptococcal pneumonia between 2013-2019, and use of antibiotics in clinical practiceen_US
dc.typeArticleen_US

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