Effect of fullerenol C60 on lung and renal tissue in lower extremity ischemia-reperfusion injury in sevoflurane-treated rats

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dc.authoridyigman, zeynep/0000-0003-1985-9280
dc.authorwosidyigman, zeynep/HTM-5876-2023
dc.contributor.authorArpaci, Ayse Hande
dc.contributor.authorKoksal, Zeynep
dc.contributor.authorYigman, Zeynep
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorSivgin, Volkan
dc.contributor.authorArslan, Mustafa
dc.contributor.authorKavutcu, Mustafa
dc.contributor.authorAkarca Dizakar, Saadet Özen
dc.date.accessioned2024-03-09T18:48:47Z
dc.date.available2024-03-09T18:48:47Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractThe aim of the present study was to examine the effect of fullerenol C60 on lung and kidney tissue in sevoflurane-treated rats with lower extremity ischemia-reperfusion (IR) injury. A total of 30 Wistar albino rats weighing 225-275 g were used and were equally divided into five groups (n=6/group): i) Sham; ii) IR; iii) IR-fullerenol C60 (IR-FUL); iv) IR-sevoflurane; and v) IR-fullerenol C60-sevoflurane (IR-FUL-SEVO). Fullerenol C60 was administered intraperitoneally prior to lower extremity IR induction and sevoflurane was administered during the IR injury. Subsequently, lung and kidney histopathological examinations, and serum biochemical analyses were performed. Lung tissue showed markedly increased congestion and neutrophil infiltration in the IR group compared with in the sham group, and notable decreases in congestion and neutrophil infiltration were observed in the treatment groups compared with in the IR group. In the histopathological evaluation of the kidney samples, vacuolization, loss of brush border in tubular epithelial cells, tubular epithelial loss and varying degrees of tubular damage were observed in all groups that underwent IR. There was a significant increase in the mean renal tubule injury score in all IR groups compared with that in the sham group. In addition, the mean kidney injury score was significantly lower in the IR-FUL and IR-FUL-SEVO groups than that in the IR group. It was observed that the expression levels of tumor necrosis factor-alpha, interleukin 1 beta and intercellular adhesion molecule 1 in the lung and kidney tissues were increased following IR, and were decreased in the groups treated with fullerenol C60 and sevoflurane. Notably, it was determined that the reduction in cytokine expression was greatest in the IR-FUL group. When the oxidant status parameters in the lungs and kidneys were examined, thiobarbituric acid reactive substances levels, and catalase and glutathione S-transferase enzyme activities were significantly different in the groups receiving sevoflurane or fullerenol C60 treatment compared with those in the IR group. The present study demonstrated the protective effects of fullerenol C60 on the lung and kidney tissues of rats under sevoflurane anesthesia after establishment of lower extremity IR. The results of the present study showed that fullerenol C60 can reduce oxidative and histopathological damage in the lungs and kidneys following IR of the lower extremities.en_US
dc.description.sponsorshipGazi University BAPen_US
dc.description.sponsorshipNot applicable.en_US
dc.identifier.doi10.3892/mmr.2024.13178
dc.identifier.issn1791-2997
dc.identifier.issn1791-3004
dc.identifier.issue3en_US
dc.identifier.pmid38334145en_US
dc.identifier.scopus2-s2.0-85184786409en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3892/mmr.2024.13178
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1479
dc.identifier.volume29en_US
dc.identifier.wosWOS:001162539000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpandidos Publ Ltden_US
dc.relation.ispartofMolecular Medicine Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFullerenol C60; Ischemia-Reperfusion; Sevoflurane; Lower Extremity; Lung; Kidneyen_US
dc.titleEffect of fullerenol C60 on lung and renal tissue in lower extremity ischemia-reperfusion injury in sevoflurane-treated ratsen_US
dc.typeArticleen_US

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