Is coronary artery tortuosity a predisposing factor for drug-eluting stent restenosis?

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dc.authorscopusid56407111700
dc.authorscopusid56157249300
dc.authorscopusid55993139900
dc.authorscopusid56365496200
dc.authorscopusid57190372281
dc.authorwosidEMREN, Zeynep YAPAN/AAV-8842-2021
dc.contributor.authorLevent, Fatih
dc.contributor.authorŞenöz, Oktay
dc.contributor.authorEmren, Sadık Volkan
dc.contributor.authorEmren, Zeynep Yapan
dc.contributor.authorGediz, Rahman Bilal
dc.date.accessioned2022-02-15T16:58:07Z
dc.date.available2022-02-15T16:58:07Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractBackground Coronary artery tortuosity (CAT) is a relatively common finding on coronary angiography and may be associated with impaired left ventricular relaxation and coronary ischemia However, the significance of CAT remains unknown. This study aimed to investigate whether the severity of tortuosity in the targeted coronary segment is a predictor of stent restenosis. Methods The study included a total of 637 patients undergoing drug-eluting stent implantation due to stable or unstable angina and who had no native coronary artery stenosis on their last coronary angiogram. The patients were separated into two groups: 312 patients with in-stent restenosis and 325 patients without in-stent restenosis. All patients underwent computed tomography (CT) coronary angiography after invasive angiography and CAT was calculated using the computer software. Results Patients with in-stent restenosis had higher CAT than those without restenosis (1.25 +/- 0.11 vs. 1.11 + 0.07, p < 0.001). Multivariate Cox regression analysis showed that the tortuosity index (hazard ratio [HR]: 1.246 95% confidence interval [CI]: 1.127-1.376 p < 0.001) and the circumflex lesion (HR: 1.437 95% CI: 1.062-1.942 p = 0.019) were independently associated with in-stent restenosis. With the threshold value of severe tortuosity set at 1.15, the prediction of could be made with 81% sensitivity and 80% specificity. Conclusion The severity of tortuosity is proportional to coronary in-stent stenosis in patients with stable and unstable angina pectoris undergoing drug-eluting stent implantation for a severe single coronary artery.en_US
dc.identifier.doi10.1007/s00059-021-05036-z
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.pmid33895890en_US
dc.identifier.scopus2-s2.0-85104831133en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1007/s00059-021-05036-z
dc.identifier.urihttps://hdl.handle.net/20.500.14034/347
dc.identifier.wosWOS:000643160800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUrban & Vogelen_US
dc.relation.journalHerzen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary restenosisen_US
dc.subjectAnginaen_US
dc.subjectunstableen_US
dc.subjectCoronary angiographyen_US
dc.subjectDrug-eluting stentsen_US
dc.subjectCoronary artery diseaseen_US
dc.titleIs coronary artery tortuosity a predisposing factor for drug-eluting stent restenosis?en_US
dc.typeArticleen_US

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