The effect of adjuvant radiotherapy on skin biophysical properties in patients with breast cancer at risk for breast lymphedema: A prospective study

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dc.authoridBakar, Yesim/0000-0002-5603-2891
dc.contributor.authorTuğral, Alper
dc.contributor.authorAkyol, Murat
dc.contributor.authorBakar, Yeşim
dc.date.accessioned2023-03-22T19:47:37Z
dc.date.available2023-03-22T19:47:37Z
dc.date.issued2023
dc.departmentBelirleneceken_US
dc.description.abstractBreast cancer (BC) is the most common type of cancer among women. Radiotherapy (RT) is one of the main and primary treatment options for BC, especially in breast-conserving surgery (BCS). BC patients who underwent RT experience a wide range of symptoms, in which breast oedema and irritation of the skin take the lion's share. Breast oedema/lymphedema, which is also a prominent side effect after RT should be well determined in earlier settings due to the chronicity of lymphedema. Therefore, this study aimed to analyze the biophysical parameters of skin on the ipsilateral (IL) and contralateral (CL) sites via Tissue dielectric constant (TDC) and Transepidermal water loss (TEWL) methods in terms of oedema and skin barrier function (SBF). The following reference points before and after the RT were measured: (R1: Pectoralis muscle, R2: Upper breast, R3: Lower breast, R4: Lateral site of the thorax). A total of 24 BC patients (mean age and BMI: 52.78 +/- 9.85 years and 28.42 +/- 5.64 kg/m(2)) were evaluated. In the IL site, the SBF was not found significant in R1-R3, whereas significantly lower SBF was observed in R4 after RT (t = -3.361, p = 0.003). A significant increase in TDC was observed in R2 at the 5.0 mm depth (t = -2.500, p = 0.02). We suggest that a longer period of follow-up should be carefully carried out to track changes in terms of SBF and oedema in the irradiated breast. The increased need for early detection of changes associated with breast lymphedema can be achievable via noninvasive, safe, cheap, and easily repeatable devices.en_US
dc.identifier.doi10.1111/cpf.12815
dc.identifier.issn1475-0961
dc.identifier.issn1475-097X
dc.identifier.pmid36799119en_US
dc.identifier.scopus2-s2.0-85149675425en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1111/cpf.12815
dc.identifier.urihttps://hdl.handle.net/20.500.14034/792
dc.identifier.wosWOS:000942653800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalClinical Physiology And Functional Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbreast edemaen_US
dc.subjectbreast lymphedemaen_US
dc.subjectskin irritationen_US
dc.subjecttissue dielectric constanten_US
dc.subjecttransepidermal water lossen_US
dc.subjectTissue Dielectric-Constanten_US
dc.subjectTransepidermal Water-Lossen_US
dc.subjectValidationen_US
dc.subjectDermatitisen_US
dc.subjectEdemaen_US
dc.titleThe effect of adjuvant radiotherapy on skin biophysical properties in patients with breast cancer at risk for breast lymphedema: A prospective studyen_US
dc.typeArticleen_US

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