Effect of surface coatings on endothelialization and biofilm in PTFE vascular grafts

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dc.authoridERKAN, Muhammet Huseyin/0000-0002-8390-2493
dc.contributor.authorErkan, Muhammet Huseyin
dc.contributor.authorBoga, Mehmet
dc.contributor.authorSalih, Hanife
dc.contributor.authorBarbarus, Emin
dc.contributor.authorRahman, Omer Faruk
dc.contributor.authorSakarya, Sarhan
dc.date.accessioned2025-03-20T09:50:45Z
dc.date.available2025-03-20T09:50:45Z
dc.date.issued2025
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractPolytetrafluoroethylene (PTFE) grafts are of great importance for vascular surgery and many methods have been developed to improve their biocompatibility. The most important of these methods is the coating of the inner surfaces of the grafts. In this study, the effects of surface coatings used in vascular grafts on endothelialization and bacterial biofilm formation were investigated. Three different PTFE graft types, heparin coated, carbon coated and uncoated, were compared. HUVEC cell culture was used for endothelialization experiments and Staphylococcus aureus strain was used for biofilm formation. Endothelialization was evaluated by inverted microscopy and scanning electron microscopy (SEM). Heparin-coated grafts showed more biofilm formation than other graft types (p < 0.01). Moderate biofilm formation was observed in carbon-coated grafts (p < 0.05). When evaluating endothelialization, heparin-coated grafts showed more cell adhesion in the first days, but lagged behind the other graft types in the following days. Carbon-coated grafts showed more endothelial cell proliferation in the long term. While biofilm formation was high in heparin-coated grafts, carbon-coated grafts provided better endothelialization. Our study showed that the coating of PTFE grafts significantly affects biocompatibility and infection risk.
dc.description.sponsorshipResearch Fund of the Aydimath;n Adnan Menderes University; Ege University Application and Research Center For Testing and Analysis
dc.description.sponsorshipThe authors would like to acknowledge Ege University Application and Research Center For Testing and Analysis (EGE MATAL) for the SEM imaging.
dc.identifier.doi10.1177/03913988251316438
dc.identifier.issn0391-3988
dc.identifier.issn1724-6040
dc.identifier.pmid39905764
dc.identifier.scopus2-s2.0-85216980808
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1177/03913988251316438
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2297
dc.identifier.wosWOS:001414738900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofInternational Journal of Artificial Organs
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectPTFE
dc.subjectheparin-coated
dc.subjectcarbon-coated
dc.subjectbiofilm
dc.subjectendothelialization
dc.subjectHUVEC
dc.titleEffect of surface coatings on endothelialization and biofilm in PTFE vascular grafts
dc.typeArticle

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