Serum hepcidin/ferroportin levels in bipolar disorder and schizophrenia

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dc.authoridAtagun, Murat Ilhan / 0000-0002-8514-0576
dc.authorscopusid57200034553
dc.authorscopusid54792689200
dc.authorscopusid57217184785
dc.authorscopusid57225889592
dc.authorscopusid57212021078
dc.authorscopusid57191630961
dc.authorscopusid7003566828
dc.authorwosidAtagun, Murat Ilhan/A-6386-2018
dc.contributor.authorAltun, İlkay Keleş
dc.contributor.authorAtagün, Murat İlhan
dc.contributor.authorErdoğan, Ali
dc.contributor.authorYenilmez, Dicle Oymak
dc.contributor.authorYusifova, Aygun
dc.contributor.authorSenat, Almila
dc.contributor.authorErel, Özcan
dc.date.accessioned2022-02-15T16:57:18Z
dc.date.available2022-02-15T16:57:18Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractBackground: Despite several alternatives for cellular iron influx, the only mechanism for cellular iron efflux is ferroportin mediated active transport. In cases of ferroportin dysfunction, iron accumulates in the cell and causes ferroptosis. Hepcidin suppresses ferroportin levels and inflammatory activation increases hepcidin production. Mild inflammation in schizophrenia and bipolar disorder may alter hepcidin and ferroportin. Methods: The study included a total of 137 patients aged 18-65 years, 57 diagnosed with schizophrenia and 80 with bipolar disorder, according to the DSM-IV diagnostic criteria, and a control group (HC) of 42 healthy in-dividuals. Biochemical analyses, thyroid function tests, hemogram, serum iron level, iron-binding capacity, and ferritin levels were examined. Serum levels of hepcidin and ferroportin were measured with enzyme-linked immunosorbent assay (ELISA) method. Results: A statistically significant difference was determined between the groups in terms of the serum ferroportin levels (F = 15.69, p < 0.001). Post-hoc analyses showed that the schizophrenia group had higher ferroportin levels than in the bipolar group (p < 0.001) and HCs (p < 0.001). Hepcidin levels did not differ between the groups. Chlorpromazine equivalent doses of antipsychotics correlated with ferroportin levels (p = 0.024). Conclusion: Ferroportin levels were increased in the schizophrenia group, although iron and hepcidin levels were within normal ranges. Antipsychotics may alter the mechanisms which control ferroportin levels. Further studies are needed to examine the relationships between antipsychotics and iron metabolism for determination of causal relationship.en_US
dc.identifier.doi10.1016/j.jtemb.2021.126843
dc.identifier.issn0946-672X
dc.identifier.issn1878-3252
dc.identifier.pmid34416474en_US
dc.identifier.scopus2-s2.0-85112781991en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2021.126843
dc.identifier.urihttps://hdl.handle.net/20.500.14034/93
dc.identifier.volume68en_US
dc.identifier.wosWOS:000702858200009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.journalJournal Of Trace Elements In Medicine And Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIronen_US
dc.subjectFerroportinen_US
dc.subjectHepcidinen_US
dc.subjectSchizophreniaen_US
dc.subjectAntipsychoticsen_US
dc.subjectRating-Scaleen_US
dc.subjectTardive-Dyskinesiaen_US
dc.subjectParkinsons-Diseaseen_US
dc.subjectAlzheimers-Diseaseen_US
dc.subjectOxidative Stressen_US
dc.subjectIronen_US
dc.subjectFerroportinen_US
dc.subjectMetabolismen_US
dc.subjectHepcidinen_US
dc.subjectErythrophagocytosisen_US
dc.titleSerum hepcidin/ferroportin levels in bipolar disorder and schizophreniaen_US
dc.typeArticleen_US

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