Evaluation of Calciferol, Cobalamin, and Stromelysin-1 in patients with Diabetic Peripheral Neuropathy due to-2 diabetes mellitus

Basit Öğe Kaydı
dc.authoridOzbek, hanefi/0000-0002-8084-7855
dc.authorwosidOzbek, hanefi/O-3472-2019
dc.contributor.authorBilir, Bülent
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorKaraarsalan, Numan
dc.contributor.authorBilir, Betül Ekiz
dc.contributor.authorKaplan, Necati
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned2023-03-22T19:47:26Z
dc.date.available2023-03-22T19:47:26Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractObjective: To evaluate the relationship between calciferol (vitamin D), cobalamin (vitamin-B12), and Stromelysin-1 (MMP-3) circu-lating levels in patients with diabetic peripheral neuropathy (DPN), patients with DM type 2 (T2DM) without neuropathy, and healthy control groups. Study Design: Cross-sectional descriptive study. Place and Duration of Study: Department of Internal Medicine, Namik Kemal University of Medicine, Tekirdag, Turkey, between November 2020 and February 2022. Methodology: Healthy, age, and gender matched volunteers who were admitted to the hospital for a check-up with no health problem constituted the control group (n=30). Cases diagnosed with T2DM (n=30) and those with DPN (n=30) comprised the experi-mental group. Stromelysin-1, calciferol, and cobalamin levels were analysed from blood samples from all groups using enzyme-linked immunosorbent assay (ELISA) with a commercial kit. Tukey's Honest Significant Difference (HSD) test was performed after one-way analysis of variance (ANOVA) for intergroup comparisons. Alpha significance level was accepted as <0.05. Results: There were significant differences in terms of the stromelysin-1, calciferol, and cobalamin levels of both the T2DM and DPN groups compared to healthy volunteers. These differences were statistically significant (p=0.00). There was a very weak negative correlation between stromelysin-1 and calciferol (p=0.972, r=-0.007) and a weak negative correlation between cobalamin and stromelysin-1 (p=0.062, r=-0.345) in DPN patients, without statistical significance. Conclusion: Serum stromelysin-1 expression may be related to DPN progression in diabetic patients and may be a potential marker in DPN. Calciferol and cobalamin levels may also be important in the development of DPN.en_US
dc.identifier.doi10.29271/jcpsp.2022.10.1255
dc.identifier.endpage1259en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue10en_US
dc.identifier.pmid36205267en_US
dc.identifier.scopus2-s2.0-85139322782en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1255en_US
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2022.10.1255
dc.identifier.urihttps://hdl.handle.net/20.500.14034/706
dc.identifier.volume32en_US
dc.identifier.wosWOS:000886033700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.journalJcpsp-Journal Of The College Of Physicians And Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalciferolen_US
dc.subjectcobalaminen_US
dc.subjectDiabetic peripheral neuropathyen_US
dc.subjectStromelysin-1en_US
dc.subjectMatrix Metalloproteinasesen_US
dc.titleEvaluation of Calciferol, Cobalamin, and Stromelysin-1 in patients with Diabetic Peripheral Neuropathy due to-2 diabetes mellitusen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Evaluation of Calciferol.pdf
Boyut:
158.15 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin / Full text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu