Protective Effect of Astaxanthin on Histopathologic Changes Induced by Bisphenol A in the Liver of Rats

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dc.authoridgultekin, burcu/0000-0001-6461-8123
dc.authoridCinar Ayan, ilknur/0000-0002-8763-0480
dc.contributor.authorKarabekir, Seda Cetinkaya
dc.contributor.authorGultekin, Burcu
dc.contributor.authorAyan, Ilknur Cinar
dc.contributor.authorSavas, Hasan Basri
dc.contributor.authorCuce, Gokhan
dc.contributor.authorKalkan, Serpil
dc.date.accessioned2025-03-20T09:50:34Z
dc.date.available2025-03-20T09:50:34Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractBisphenol A (BPA) has several potential uses, including in polycarbonate plastics and epoxy resins, which could expose humans to it. Recognized for its hepatotoxicity and ability to accumulate in organs. We prompted this study to explore the hepatoprotective potential of astaxanthin (ASTX), an antioxidant against BPA toxicity. We used 32 male Wistar Albino rats and randomly assigned them as: Control, Sham (olive oil), BPA, and BPA+ASTX. At the end of the experiment, Native Thiol, Total Thiol, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured in serum samples. Histopathological scoring was performed to evaluate the changes caused by ASTX in the liver. Caspase 3 and caspase 9 expression in liver tissues was demonstrated immunohistochemically and by PCR. Collagen I (COL1A1) and collagen III (COL3A1) mRNA levels were measured by PCR in the tissue samples. The BPA group showed elevated AST and ALT with decreased Thiol levels. ASTX administration reversed these changes as observed by reduced AST and ALT levels and increased Thiol levels. Histopathology indicated increased liver damage and fibrosis in the BPA group which were alleviated in the BPA+ASTX group. Gene expression analyses revealed upregulated COL1A1 and COL3A1 in BPA, which was downregulated with ASTX. Immunohistochemistry and PCR confirmed BPA-induced caspase 3 and caspase 9 expression, which were attenuated by ASTX. This study underscores ASTX's hepatoprotective efficacy against BPA-induced hepatotoxicity which ultimately attributed to its antioxidant and antiapoptotic properties. Consequently, ASTX emerges as a promising therapeutic agent for preventing and treating BPA-related liver diseases.
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordination Office [211218026]
dc.description.sponsorshipFunding: This project was supported by the Necmettin Erbakan University Scientific Research Projects Coordination Office (Project No: 211218026)
dc.identifier.doi10.29261/pakvetj/2024.178
dc.identifier.endpage251
dc.identifier.issn0253-8318
dc.identifier.issn2074-7764
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85198604491
dc.identifier.scopusqualityQ1
dc.identifier.startpage244
dc.identifier.urihttps://doi.org/10.29261/pakvetj/2024.178
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2259
dc.identifier.volume44
dc.identifier.wosWOS:001283050200005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Agriculture, Fac Veterinary Science
dc.relation.ispartofPakistan Veterinary Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjectAstaxanthin
dc.subjectBisphenol A
dc.subjectApoptosis
dc.subjectOxidative stress
dc.subjectFibrosis
dc.titleProtective Effect of Astaxanthin on Histopathologic Changes Induced by Bisphenol A in the Liver of Rats
dc.typeArticle

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