The correlation between peroxisome proliferator-activated receptor alpha and gamma polymorphisms and acute coronary syndrome

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dc.authoridKöseler, Aylin/0000-0003-4832-0436
dc.authoridKEMANCI, Aykut/0000-0002-6308-3830
dc.authorwosidkemanci, aykut/GQP-8081-2022
dc.authorwosidKöseler, Aylin/C-5030-2012
dc.contributor.authorKemancı, Aykut
dc.contributor.authorGören, Tarık
dc.contributor.authorUlutürk, Mehmet
dc.contributor.authorYılmaz, Atakan
dc.contributor.authorSabırlı, Ramazan
dc.contributor.authorÖzen, Mert
dc.contributor.authorSeyit, Murat
dc.date.accessioned2023-03-22T19:47:36Z
dc.date.available2023-03-22T19:47:36Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractObjective: This study aims to evaluate the relationship between peroxisome proliferator-activated receptor (PPAR) alpha and gamma gene polymorphisms and acute coronary syndrome (ACS) clinically. Subject and methods: Peripheral blood samples were collected from a total of 200 people, including 100 acute coronary syndrome patients and 100 controls aged 19 to 93 years, admitted to the Pamukkale University Emergency Medicine Department. The healthy volunteers had no known chronic or acute diseases, no history of drug use, and no recent history of coronary artery disease (CAD). PPAR alpha L162V and PPAR gamma C161T gene polymorphic regions were detected using DNA sequencing analyses. In addition, data collected from the hemogram and biochemical parameters and comorbidities of the patients were statistically analyzed. Results: PPAR gamma C161T polymorphisms were compared between groups. The CT heterozygous rate in the patient group (74%) was higher than in the control group (7%). The T allele was more common in the patient group (0.37) compared to the control group (0.03). When PPAR alpha L162V polymorphism was compared, VV homozygous individuals were %19 in the patient group and none in the control group. The V allele was found to be statistically higher in patients with ACS (p<0.01). Conclusion: The findings revealed that elevated PPAR alpha L162V and PPAR gamma C161T gene polymorphisms were associated with a progressive risk of ACS.en_US
dc.identifier.doi10.7759/cureus.26147
dc.identifier.issn2168-8184
dc.identifier.issue6en_US
dc.identifier.pmid35891836en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.26147
dc.identifier.urihttps://hdl.handle.net/20.500.14034/788
dc.identifier.volume14en_US
dc.identifier.wosWOS:000836563000009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCureus Incen_US
dc.relation.journalCureus Journal Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmutationen_US
dc.subjectpolymorphismen_US
dc.subjectcoronary heart diseaseen_US
dc.subjectacute coronary syndromeen_US
dc.subjectppar gammaen_US
dc.subjectppar alphaen_US
dc.subjectRisk-Factorsen_US
dc.subjectPpar-Gammaen_US
dc.subjectGeneen_US
dc.subjectExpressionen_US
dc.subjectDiseaseen_US
dc.titleThe correlation between peroxisome proliferator-activated receptor alpha and gamma polymorphisms and acute coronary syndromeen_US
dc.typeArticleen_US

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