Clinical and Electrophysiological Features Predicting Response to Antiseizure Medications in Juvenile Absence Epilepsy

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dc.authoridGazeteci Tekin, Hande/0000-0002-4407-164X
dc.contributor.authorKaraoglu, Pakize
dc.contributor.authorTekin, Hande Gazeteci
dc.date.accessioned2023-03-22T19:47:22Z
dc.date.available2023-03-22T19:47:22Z
dc.date.issued2023
dc.departmentBakırçay University, Çiğli Regional Education Hospital, Department of Pediatrics, Division of Pediatric Neurology, İzmir, Turkeyen_US
dc.description.abstractBackground We aimed to evaluate the clinical findings and electroencephalographic (EEG) characteristics of patients with juvenile absence epilepsy (JAE) and to determine the factors that predict response to antiseizure medications (ASMs) in JAE. Methods We reviewed the medical records of 29 patients with JAE. The patients who were seizure-free during the last 12 months of their follow-up and who did not have generalized spike waves on their last EEG were considered as the treatment-responsive group, and the patients whose clinical seizures persisted during the last 12 months of their follow-up or who had generalized spike waves on their follow-up EEGs were considered as patients who did not respond to ASMs. Results There were 29 patients, 20 girls and nine boys, with a mean age of 13.34 +/- 2.17 years and a follow-up time of 32.1 +/- 11.9 months. Twenty-two cases (75.8%) were evaluated as responsive to treatment. Generalized tonic-clonic seizures (GTCS) were statistically more common in patients who did not respond to ASM. Epileptic seizures began at a younger age in the group that responded to medication. Occipital intermittent rhythmic delta activity (OIRDA) in EEG was significantly higher in the group that responded to the medication. Conclusion Our study shows that concomitant GTCS may predict poorer response to ASMs in JAE. Younger age at diagnosis and OIRDA on EEG may be associated with better response to treatment. Our findings need to be confirmed by further prospective and long-term studies.en_US
dc.identifier.doi10.1055/s-0042-1757709
dc.identifier.endpage5en_US
dc.identifier.issn0174-304X
dc.identifier.issn1439-1899
dc.identifier.issue1en_US
dc.identifier.pmid36564022en_US
dc.identifier.scopus2-s2.0-85146365275en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2en_US
dc.identifier.urihttps://doi.org/10.1055/s-0042-1757709
dc.identifier.urihttps://hdl.handle.net/20.500.14034/659
dc.identifier.volume54en_US
dc.identifier.wosWOS:000903421900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.journalNeuropediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantiseizure medicationen_US
dc.subjectjuvenile absence epilepsyen_US
dc.subjecttreatmenten_US
dc.subjectprognosisen_US
dc.subjectLong-Term Prognosisen_US
dc.subjectChildhooden_US
dc.subjectChildrenen_US
dc.titleClinical and Electrophysiological Features Predicting Response to Antiseizure Medications in Juvenile Absence Epilepsyen_US
dc.typeArticleen_US

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