The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis

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dc.authoridGuney, Gurhan/0000-0002-0093-2743
dc.authorwosidGuney, Gurhan/R-1454-2018
dc.contributor.authorGuney, Gurhan
dc.contributor.authorTaskin, Mine Islimye
dc.contributor.authorSener, Nazli
dc.contributor.authorTolu, Ezgi
dc.contributor.authorDodurga, Yavuz
dc.contributor.authorElmas, Levent
dc.contributor.authorCetin, Orkun
dc.date.accessioned2023-03-22T19:47:39Z
dc.date.available2023-03-22T19:47:39Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractBackground Ovulation is regulated by extracellular signal-regulated kinase-1 (ERK-1) and ERK-2 signaling mechanisms, and ERK-1/2 kinases modulates the function of most of the LH-regulated genes. Defective ERK kinase signaling that is secondary to a genetic problem contributes to both ovulatory dysfunction and metabolic problems in polycystic ovary syndrome (PCOS). We planned to investigate ERK-1 and ERK-2 gene polymorphisms in PCOS for the first time in the Turkish population. Methods One hundred two PCOS patients and 102 healthy controls were recruited for this patient control study. HOMA-IR, Ferriman-Gallwey score (FGS), waist-to-hip ratio (WHR), and body mass index (BMI) were assessed. Lipid profile levels, CRP, and total testosterone were determined. ERK-2 rs2276008 (G > C) and ERK-1 rs11865228 (G > A) SNPs were analyzed with a real-time PCR system. Results ERK-1 and ERK-2 genotypes were found to differ between the PCOS and control groups. In patients with PCOS, ERK-1 GA and ERK-2 GC genotypes were different in terms of BMI, FGS, HOMA-IR, CRP, total testosterone, and total cholesterol levels. Conclusions ERK-1 and ERK-2 genes are involved in PCOS pathogenesis. BMI, FGS, HOMA-IR, and CRP levels are related to the heterozygote polymorphic types of ERK-1 and ERK-2 genes.en_US
dc.description.sponsorshipBalikesir University Scientific Investigations Foundation [2017/48]en_US
dc.description.sponsorshipThe Balikesir University Scientific Investigations Foundation supported our study (Project number: 2017/48).en_US
dc.identifier.doi10.1186/s12958-022-00967-6
dc.identifier.issn1477-7827
dc.identifier.issue1en_US
dc.identifier.pmid35768803en_US
dc.identifier.scopus2-s2.0-85133141325en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s12958-022-00967-6
dc.identifier.urihttps://hdl.handle.net/20.500.14034/813
dc.identifier.volume20en_US
dc.identifier.wosWOS:000818758300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.journalReproductive Biology And Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPCOSen_US
dc.subjectERK-1en_US
dc.subjectERK-2en_US
dc.subjectGenetic polymorphismen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectKinaseen_US
dc.subjectErk1/2en_US
dc.subjectCellsen_US
dc.subjectMapken_US
dc.titleThe role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesisen_US
dc.typeArticleen_US

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