Sleep Quality and Its Predictors among Dyspnea, Fatigue and Exercise Capacity in Pulmonary Arterial Hypertension

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dc.authoridZeren, Melih/0000-0002-9749-315X
dc.contributor.authorCeylan, Raziye
dc.contributor.authorDemir, Rengin
dc.contributor.authorZeren, Melih
dc.contributor.authorSinan, Umit Yasar
dc.contributor.authorKucukoglu, Mehmet Serdar
dc.date.accessioned2025-03-20T09:49:14Z
dc.date.available2025-03-20T09:49:14Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractBackground: Poor sleep quality is an overlooked symptom in patients with pulmonary arterial hypertension (PAH), however it may significantly contribute to disease burden. Objectives: The aim of this study was to assess the sleep quality of patients with PAH and investigate its association with dyspnea, fatigue, and exercise capacity. Methods: Forty-five patients were included. Sleep quality of the patients was assessed by the Pittsburgh Sleep Quality Index (PSQI), dyspnea levels were assessed by the UCSD-Shortness of Breath Questionnaire (UCSD-SOBQ), Baseline Dyspnea Index (BDI), Modified Medical Research Council (MMRC) dyspnea scale and Modified Borg Dyspnea scale, fatigue levels were evaluated with the Fatigue Severity Scale and Borg Rating of Perceived Exertion, and functional exercise capacity was evaluated with the 6-minute walk test (6MWT). Results: Among the patients with PAH, 64% had poor sleep quality (PSQI > 5). PSQI score was significantly correlated with MMRC scale (r = -0.561), UCSD-SOBQ (r = 0.497), BDI (r = -0.468), and 6MWT (r = -0.412) (p < 0.05). There was no significant relationship between sleep quality and fatigue. A regression model including MMRC and 6MWT could explain 32% of variance in PSQI (p < 0.05), and MMRC score was an independent predictor for PSQI (p < 0.05). In addition, MMRC score had a greater influence on PSQI than 6MWT ((3 = 0.548 vs. 0.019). Conclusions: Poor sleep quality is common in patients with PAH and is associated with poor exercise capacity and dyspnea. Patients with severe dyspnea are particularly at higher risk of poor sleep quality. Consideration of sleeprelated complaints and underlying mechanisms when planning symptomatic treatments for these patients may help provide better management for PAH.
dc.identifier.doi10.6515/ACS.202409_40(5).20240712A
dc.identifier.endpage626
dc.identifier.issn1011-6842
dc.identifier.issue5
dc.identifier.pmid39308648
dc.identifier.scopus2-s2.0-85204980175
dc.identifier.scopusqualityQ3
dc.identifier.startpage618
dc.identifier.urihttps://doi.org/10.6515/ACS.202409_40(5).20240712A
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2177
dc.identifier.volume40
dc.identifier.wosWOS:001318548400009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaiwan Soc Cardiology
dc.relation.ispartofActa Cardiologica Sinica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectDyspnea
dc.subjectExercise capacity
dc.subjectFatigue
dc.subjectPulmonary arterial hypertension
dc.subjectQuality of life
dc.subjectSleep
dc.titleSleep Quality and Its Predictors among Dyspnea, Fatigue and Exercise Capacity in Pulmonary Arterial Hypertension
dc.typeArticle

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