Do pulmonary and extrapulmonary features differ among cystic fibrosis, primary ciliary dyskinesia, and healthy children?

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dc.authoridGurses, H. Nilgun / 0000-0002-5846-6781
dc.authoridUcgun, Hikmet / 0000-0002-7211-1805
dc.authoridDENIZOGLU KULLI, Hilal / 0000-0002-8003-4440
dc.authoridZeren, Melih / 0000-0002-9749-315X
dc.authorscopusid57200518528
dc.authorscopusid7006651111
dc.authorscopusid57192204790
dc.authorscopusid57218882596
dc.authorscopusid15757040700
dc.authorwosidGurses, H. Nilgun/AAD-3070-2020
dc.authorwosidUcgun, Hikmet/AAC-5606-2020
dc.contributor.authorDenizoğlu Kulli, Hilal
dc.contributor.authorGürses, Hülya Nilgün
dc.contributor.authorZeren, Melih
dc.contributor.authorÜçgün, Hikmet
dc.contributor.authorÇakır, Erkan
dc.date.accessioned2022-02-15T16:57:31Z
dc.date.available2022-02-15T16:57:31Z
dc.date.issued2020
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractBackground Primary ciliary dyskinesia (PCD) is generally likened to cystic fibrosis (CF) due to similarities in impaired mucociliary clearance and some other symptoms. The aim of our study was to investigate pulmonary and extrapulmonary characteristics of children with CF and PCD since no studies have addressed respiratory muscle strength in children with PCD and to compare the results to those obtained from healthy age-matched controls. Methods Pulmonary and extrapulmonary characteristics were assessed by 6-min walk test, spirometry, maximum inspiratory and expiratory pressure measurements, and knee extensor strength test in the children with CF, PCD, and healthy controls. Results Children with PCD and CF had similar PFT results, except forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) which was lower in PCD (p = .04). Maximum inspiratory pressure (MIP) value was lower in the children with CF compared with the healthy controls (p = .016), MEP value of the children with PCD was worse than those with CF and healthy controls (p = .013 and p = .013), respectively. 6-min walk test (6MWT) distance of the children with CF was lower than their healthy counterparts (p = .003). Knee extensor muscle strength differed among the children with PCD, CF, and healthy control groups, but post hoc test failed to show statistical significance (p = .010). Conclusion Children with CF and PCD had some impairments in pulmonary functions, respiratory muscle strength, functional capacity, and peripheral muscle strength compared with healthy children. However, the unique characteristics of each disease should be considered during physiotherapy assessment and treatment. The clinicians may especially focus on the respiratory and peripheral muscle strength of the children with PCD.en_US
dc.identifier.doi10.1002/ppul.25052
dc.identifier.endpage3073en_US
dc.identifier.issn8755-6863
dc.identifier.issn1099-0496
dc.identifier.issue11en_US
dc.identifier.pmid32877003en_US
dc.identifier.scopus2-s2.0-85090584064en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3067en_US
dc.identifier.urihttps://doi.org/10.1002/ppul.25052
dc.identifier.urihttps://hdl.handle.net/20.500.14034/192
dc.identifier.volume55en_US
dc.identifier.wosWOS:000567889400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalPediatric Pulmonologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcystic fibrosisen_US
dc.subjectfunctional capacityen_US
dc.subjectlung functionen_US
dc.subjectmuscle strengthen_US
dc.subjectprimary ciliary dyskinesiaen_US
dc.subjectrespiratory muscle strengthen_US
dc.subjectOxygen-Uptake Kineticsen_US
dc.subjectMuscle Functionen_US
dc.subjectLung-Functionen_US
dc.subjectAdultsen_US
dc.subjectGuidelinesen_US
dc.subjectDiagnosisen_US
dc.subjectExerciseen_US
dc.subjectStatementen_US
dc.subjectStrengthen_US
dc.subjectDiseaseen_US
dc.titleDo pulmonary and extrapulmonary features differ among cystic fibrosis, primary ciliary dyskinesia, and healthy children?en_US
dc.typeArticleen_US

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