Demographic, clinical and laboratory characteristics for differential diagnosis of peripheral lymphadenopathy (LAP) and the etiologic distribution of LAP in adults; a multicenter, nested case-control study including 1401 patients from Turkey

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dc.authoridCaliskan Demirkiran, Burcu / 0000-0001-9525-0122
dc.authorscopusid35796741600
dc.authorscopusid57219016102
dc.authorscopusid57188754344
dc.authorscopusid57222495659
dc.authorscopusid57193550439
dc.authorscopusid53880991800
dc.authorscopusid8382298500
dc.contributor.authorYenilmez, Ercan
dc.contributor.authorVerdi, Yıldız
dc.contributor.authorİlbak, Ayca
dc.contributor.authorDemirkıran, Burcu Çalışkan
dc.contributor.authorDuman, Zehra
dc.contributor.authorBozkurt, Fatma
dc.contributor.authorKöşe, Şükran
dc.date.accessioned2022-02-15T16:58:56Z
dc.date.available2022-02-15T16:58:56Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractPeripheral lymphadenopathy (LAP) is an important and common abnormal finding of the physical exam in general medical practice. We aimed to reveal the LAP etiology and demographic, clinical and laboratory variables that may be useful in the differential evaluation of LAP. This multicenter, nested case-control study including 1401 patients between 2014 and 2019 was conducted in 19 tertiary teaching and research hospitals from different regions in Turkey. The ratio of infectious, malign and autoimmune/inflammatory diseases was 31.3%, 5% and 0.3%, respectively. In 870 (62%) of patients had nonspecific etiology. Extrapulmonary tuberculosis (n: 235, 16.8%) was the most frequent cause of LAP. The ratio of infective etiology of LAP was significantly lower in patients older than 65 years-old compared to younger patients with the rate of 66.67% and 83.84%, respectively (p 0.016, OR 0.386, 95% Cl 0.186-0.803). The probability of malign etiology was higher both in patients who are older than 45 years-old (p < 0.001, OR 3.23, 95% Cl 1.99-5.26) and older than 65 years-old (p 0.002, OR 3.36, 95% Cl 1.69-6.68). Age, localization and duration of LAP, leukocytosis, anemia, thrombocytopenia, CRP and sedimentation rate were important parameters to differentiate infections. Size of lymph node and splenomegaly in addition to the parameters above were useful parameters for differentiating malign from benign etiology. Despite the improvements in diagnostic tools, reaching a definite differential diagnosis of lymphadenopathy is still challenging. Our results may help clinicians to decide in which cases they need an aggressive workup and set strategies on optimizing the diagnostic approach of adulthood lymphadenopathy.en_US
dc.identifier.doi10.1007/s11739-021-02683-2
dc.identifier.endpage2153en_US
dc.identifier.issn1828-0447
dc.identifier.issn1970-9366
dc.identifier.issue8en_US
dc.identifier.pmid33728579en_US
dc.identifier.scopus2-s2.0-85102892217en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2139en_US
dc.identifier.urihttps://doi.org/10.1007/s11739-021-02683-2
dc.identifier.urihttps://hdl.handle.net/20.500.14034/488
dc.identifier.volume16en_US
dc.identifier.wosWOS:000629457100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.journalInternal And Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLymphadenopathyen_US
dc.subjectLAPen_US
dc.subjectEtiologyen_US
dc.subjectTurkeyen_US
dc.titleDemographic, clinical and laboratory characteristics for differential diagnosis of peripheral lymphadenopathy (LAP) and the etiologic distribution of LAP in adults; a multicenter, nested case-control study including 1401 patients from Turkeyen_US
dc.typeArticleen_US

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