Is serum vitamin D level a risk factor for idiopathic male fertility?

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dc.authoridISSI, Yasar / 0000-0002-2515-8483
dc.authoridHORSANALI, Mustafa Ozan / 0000-0002-3651-0948
dc.authorwosidISSI, Yasar/A-8712-2014
dc.authorwosidHORSANALI, Mustafa Ozan/AAU-2142-2021
dc.contributor.authorHorsanalı, Mustafa Ozan
dc.contributor.authorEren, Hüseyin
dc.contributor.authorÇağlayan, Alper
dc.contributor.authorIssı, Yaşar
dc.date.accessioned2022-02-15T16:57:51Z
dc.date.available2022-02-15T16:57:51Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractBackground: Idiopathic male infertility is a health problem that is increasingly common worldwide. Aetiology of idiopathic male infertility is still controversial. In this cross-sectional retrospective study, we aimed to investigate the relationship between serum vitamin D level and sperm quality in patients with idiopathic male infertility. Methods: Between June 2018 and June 2020, 297 patients including 147 men with idiopathic infertility (as a study group) and 150 fertile men (as a control group) were retrospectively enrolled into the study. Blood samples were collected, and these samples included serum sex steroids, serum vitamin D levels, glucose tests, lipid profiles, liver function tests and kidney function tests. At least two sperm analyses, scrotal doppler ultrasonography and karyotype analysis were performed on each of the patients. Demographic, laboratory and radiological features were also recorded. The Mann Whitney-U test was used to compare groups and quantitative independent data. The Chi-square test was used for qualitative independent data. Spearman's correlation analysis was applied for correlation. Significant results were investigated and analysed further using the logistic regression test. Results: The mean age of the patients was 31.98 +/- 6.97 years. The mean serum vitamin D level of the patients was 23.16 +/- 10.40 ng/dL and the mean infertility duration of patients with idiopathic infertility was 29.88 +/- 28.86 months. We observed statistical significance in terms of serum vitamin D levels, impaired total sperm motility, progressive sperm motility and sperm morphology in idiopathic infertile men when compared to fertile men. There were no statistically significant between idiopathic infertile men and fertile men in terms of serum testosterone levels. Conclusions: We observed a positive correlation between serum vitamin D levels and impaired sperm parameters, specifically in terms of sperm morphology, total sperm motility and progressive sperm motility. Vitamin D supplementation may be a beneficial contribution to achieving high paternity rates in men with idiopathic male infertility.en_US
dc.identifier.doi10.31083/jomh.2021.138
dc.identifier.issn1875-6867
dc.identifier.issn1875-6859
dc.identifier.scopus2-s2.0-85136736410en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.31083/jomh.2021.138
dc.identifier.urihttps://hdl.handle.net/20.500.14034/291
dc.identifier.wosWOS:000712307700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIMR Pressen_US
dc.relation.journalJournal Of Mens Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInfertilityen_US
dc.subjectVitamin Den_US
dc.subjectTestosteroneen_US
dc.subjectSemenen_US
dc.subjectSpermiogramen_US
dc.subjectTestosteroneen_US
dc.subjectAssociationen_US
dc.subjectReceptoren_US
dc.subjectHormonesen_US
dc.subjectQualityen_US
dc.subjectCalciumen_US
dc.titleIs serum vitamin D level a risk factor for idiopathic male fertility?en_US
dc.typeArticleen_US

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