Risk Factors for Presence of Resistant Microorganisms in Sputum Cultures of Patients with Infectious Exacerbations of Chronic Obstructive Lung Disease

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dc.authoridSenol, Gunes/0000-0002-1027-7578
dc.authoridBuyuksirin, Melih/0000-0003-0700-2546
dc.authoridPolat, Gulru/0000-0002-2211-1268
dc.contributor.authorBuyuksirin, Melih
dc.contributor.authorSenol, Gunes
dc.contributor.authorPolat, Gulru
dc.contributor.authorAyranci, Aysu
dc.contributor.authorGuldaval, Filiz
dc.contributor.authorSerce Unat, Damla
dc.date.accessioned2023-03-22T19:47:18Z
dc.date.available2023-03-22T19:47:18Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractIntroduction: Antibiotics reduce the risk of short-term mortality. Certain bacteria may be resistant to initial regimens which is related to mortality. The aim of this study was to find risk factors for the presence of resistant bacteria during exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Materials and Methods: Ethics committee approval was obtained for the study. The patients hospitalized with an exacerbation of COPD between 2015 and 2020 were retrospectively ieviewed. The patients with a sputum culture result were divided into: Group A with conventional microorganisms (susceptible to initial antibiotic regimen) and Group B with non-conventional microorganisms (resistant to initial antibiotic regimen). The risk factors for Group B microorganisms were investigated. Results: One hundred and nineteen patients were included in the study. Median age was 68 (40-88) years. There were 22 patients in Group A and 97 in Group B. Most common microorganism in Group A was Haemophilus influenza (12.6%). Most encountered microorganisms in Group B were Pseudomonas aeruginosa (49.6%). Male sex (HR= 2.9; 95% CI= 0.9-9.5; p= 0.073), age >61 (HR=4.8; 95% CI= 1.7-13.6; p= 0.003), and >5 hospitalizations last year (HR= 8.2; 95% CI= 0.9-67.7; p= 0.051) were found to be independent risk factors for resistant microorganisms. Conclusion: Proposed risk factors for the isolation of multidrug resistant microorganism in patients hospitalized with COPD exacerbations should be considered when choosing the initial antibiotic regimen.en_US
dc.identifier.doi10.5578/flora.20229904
dc.identifier.endpage44en_US
dc.identifier.issn1300-932X
dc.identifier.issue1en_US
dc.identifier.startpage37en_US
dc.identifier.trdizinid521356en_US
dc.identifier.urihttps://doi.org/10.5578/flora.20229904
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/521356
dc.identifier.urihttps://hdl.handle.net/20.500.14034/608
dc.identifier.volume27en_US
dc.identifier.wosWOS:000791588600005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherBilimsel Tip Yayinevien_US
dc.relation.journalFlora Infeksiyon Hastaliklari Ve Klinik Mikrobiyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRisk factorsen_US
dc.subjectResistant microorganismsen_US
dc.subjectInfectious exacerbation of COPDen_US
dc.subjectPseudomonas-Aeruginosaen_US
dc.subjectPulmonary-Diseaseen_US
dc.subjectCopden_US
dc.subjectPrevalenceen_US
dc.titleRisk Factors for Presence of Resistant Microorganisms in Sputum Cultures of Patients with Infectious Exacerbations of Chronic Obstructive Lung Diseaseen_US
dc.typeArticleen_US

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