Comparison of rapid antibody test and thorax computed tomography results in patients who underwent RT-PCR with the pre-diagnosis of COVID-19

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dc.authoridSener, Asli / 0000-0002-2107-9438
dc.authorscopusid57193830802
dc.authorscopusid57225076373
dc.authorscopusid57195452364
dc.authorwosidKiziloglu, Ilker/ABD-6133-2021
dc.contributor.authorKızıloğlu, İlker
dc.contributor.authorŞener, Aslı
dc.contributor.authorSiliv, Neslihan
dc.date.accessioned2022-02-15T16:58:02Z
dc.date.available2022-02-15T16:58:02Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractIntroduction In this study, it is planned to compare the real-time reverse transcription-polymerase chain reaction (RT-PCR) test, which is the gold standard in the diagnosis of COVID-19, with thorax computed tomography (CT) and rapid antibody test results. Methods Patients who were admitted to the emergency service of Izmir cigli Training and Research Hospital between 01.04.2020 and 31.05.2020 and who were suspected of having COVID-19 infection were included in the study. The medical records of the patients were retrospectively analysed through the hospital data processing database. Age, gender, hospitalisation, status of home quarantine, real-time RT-PCR, thorax CT and rapid antibody test results of the patients were examined. The relationship between RT-PCR, thorax CT and rapid antibody test results was compared statistically. Results A total of 181 patients, 115 (63.5%) male and 66 (36.5%) female, with an average age of 56.4 +/- 18.06 years were included in the study. The nasopharyngeal swab PCR result obtained at the first admission of the patients to the emergency department was positive in 71 (39.2%) patients. Rapid antibody tests performed at hospital admission were positive in 57 (31.5%) patients. Thorax CT was performed in 173 (95.6%) patients who applied to the emergency department, and 112 (64.7%) of them had findings that could be compatible with COVID-19. According to the thorax CT findings in patients, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for detecting COVID-19 infection were, respectively, 76.1%, 43.1%, 48.2% and 72.1% (kappa: 0.176, P < .001). According to the rapid antibody test results, sensitivity, specificity, PPV and NPV for detecting COVID-19 infection were 57.5%, 85.5%, 71.9% and 75.8%, respectively (kappa: 0.448, P < .001). In our study, the mortality rate for COVID-19 was found to be 2.8%. Conclusion Rapid antibody test and thorax CT examinations were found to have low diagnostic value in patients who admitted to the emergency department of our hospital and whose first RT-PCR SARS-CoV-2 test was positive. Studies involving larger patient groups are needed for their use alone in diagnosis and screening.en_US
dc.identifier.doi10.1111/ijcp.14524
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.pmid34120388en_US
dc.identifier.scopus2-s2.0-85109105496en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/ijcp.14524
dc.identifier.urihttps://hdl.handle.net/20.500.14034/331
dc.identifier.wosWOS:000669929100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal Of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSars-Cov-2 Infectionsen_US
dc.subjectChest Cten_US
dc.subjectCoronavirusen_US
dc.titleComparison of rapid antibody test and thorax computed tomography results in patients who underwent RT-PCR with the pre-diagnosis of COVID-19en_US
dc.typeArticleen_US

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